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AB113651

Anti-SCAMP4 antibody

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(1 Publication)

Rabbit Polyclonal SCAMP4 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SCAMP4 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Secretory carrier-associated membrane protein 4, Secretory carrier membrane protein 4, SCAMP4

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCAMP4 antibody (AB113651)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCAMP4 antibody (AB113651)

ab113651, at 5 µg/ml, staining SCAMP4 in formalin fixed, paraffin embedded Human breast tissue by Immunohistochemistry.

Western blot - Anti-SCAMP4 antibody (AB113651)
  • WB

Unknown

Western blot - Anti-SCAMP4 antibody (AB113651)

Lane 1:

Western blot - Anti-SCAMP4 antibody (ab113651) at 1 µg/mL

Lane 2:

Western blot - Anti-SCAMP4 antibody (ab113651) at 2 µg/mL

All lanes:

3T3 cell lysate

Predicted band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human SCAMP4 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q969E2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCAMP4 also known as Secretory Carrier Membrane Protein 4 mechanically participates in cellular transport processes. It is part of a family of proteins involved in membrane trafficking. SCAMP4 has a molecular mass of about 20 kDa and localizes to the trans-Golgi network and the recycling endosomes. Researchers have observed its expression in many tissues including the brain and heart where it might help shape vesicular transport dynamics.
Biological function summary

This transport-related protein contributes to vesicle-mediated eukaryotic trafficking mechanisms. SCAMP4 does not function alone; it operates inside a group of proteins that manage and regulate vesicle cycling and fusion. By facilitating membrane fusion events SCAMP4 modulates transport activities integral to the functional maintenance of cells such as synaptic vesicle recycling and receptor endocytosis.

Pathways

The eukaryotic trafficking system integrates SCAMP4’s activity into larger cellular processes. SCAMP4 engages in the endocytic pathway where it helps regulate the recycling of membrane receptors. It also participates in the synaptic vesicle pathway where its interactions with other proteins like clathrin influence synaptic vesicle recycling and neuro-transmitter release playing a role in nerve signal transmission.

Irregular SCAMP4 activity links to neurodegenerative conditions and cardiac dysfunctions. Abnormalities in its expression can disrupt normal endocytosis and synaptic transmission potentially contributing to disorders like Alzheimer's disease. In heart tissue SCAMP4 imbalances might affect cardiac function making it relevant to certain heart diseases. The connection to proteins like amyloid precursor protein (APP) in Alzheimer's disease pathways suggests SCAMP4 as a potential target for therapeutic intervention or research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probably involved in membrane protein trafficking.
See full target information SCAMP4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

World journal of oncology 6:473-484 PubMed28983350

2015

GOLPH3 and YB-1 Are Novel Markers Correlating With Poor Prognosis in Prostate Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Nehad M R Abd El-Maqsoud,Nisreen A A Osman,Amr M A El-Hamid,Tarek K Fath El-Bab,Ehab M Galal
View all publications
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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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