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AB3432

Anti-SCAMP5 antibody

4

(2 Reviews)

|

(4 Publications)

Rabbit Polyclonal SCAMP5 antibody. Suitable for WB and reacts with Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Rat Scamp5 aa 200 to C-terminus.

View Alternative Names

Secretory carrier-associated membrane protein 5, Secretory carrier membrane protein 5

1 Images
Western blot - Anti-SCAMP5 antibody (AB3432)
  • WB

Supplier Data

Western blot - Anti-SCAMP5 antibody (AB3432)

All lanes:

Western blot - Anti-SCAMP5 antibody (ab3432)

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Rat brain extract

Predicted band size: 26 kDa

Observed band size: 25 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Rat Scamp5 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9JKE3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCAMP5 also known as Secretory Carrier Membrane Protein 5 plays an important role in vesicular trafficking. This protein has a molecular weight of approximately 38 kDa and is primarily expressed in the nervous system especially in neurons. SCAMP5 localizes mainly to synaptic vesicles where it engages in the regulation of exocytosis. It functions in membrane trafficking by facilitating vesicle fusion and recycling which is essential for neural communication.
Biological function summary

SCAMP5 influences synaptic transmission and neuronal signaling. It participates in the exocytic machinery required for neurotransmitter release. SCAMP5 integrates into membrane complexes that include proteins involved in vesicle docking and fusion. The presence of SCAMP5 in these complexes underlines its importance in maintaining efficient synaptic function. Additionally its expression is linked to neural differentiation and plasticity.

Pathways

Neurons employ SCAMP5 within the synaptic vesicle cycle and neurotransmitter release pathways. SCAMP5 collaborates with proteins such as synaptotagmin and SNARE proteins to ensure precise synaptic vesicle fusion with the presynaptic membrane. This coordination is essential for maintaining synaptic transmission efficiency and plasticity. The interaction within these pathways showcases SCAMP5's role in neurotransmitter regulation and highlights its position in neural activity modulation.

SCAMP5 associates with neurological conditions such as epilepsy and schizophrenia. Abnormalities in SCAMP5 expression or function can lead to disrupted synaptic processes. It exhibits connections with proteins like synaptophysin which also affect synaptic vesicle dynamics. Understanding SCAMP5's role in these disorders may prove helpful in developing therapeutic strategies targeting synaptic dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity).
See full target information Scamp5
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:995974 PubMed36203606

2022

Identification of immune-related endoplasmic reticulum stress genes in sepsis using bioinformatics and machine learning.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Gong,Yongbin Liu,Zhiyuan Tian,Min Zhang,Hejun Gao,Zhiyong Peng,Shuang Yin,Chi Wai Cheung,Youtan Liu

ACS chemical neuroscience 9:3137-3152 PubMed30052418

2018

Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia.

Applications

Unspecified application

Species

Unspecified reactive species

Dafina M Angelova,David R Brown

PloS one 12:e0180892 PubMed28700687

2017

Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome.

Applications

WB, WB

Species

Human, Rat

Yi Yang,Meiling Qin,Puhua Bao,Wangchao Xu,Jin Xu

The Journal of biological chemistry 284:11318-25 PubMed19240033

2009

SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition.

Applications

ICC/IF

Species

Unspecified reactive species

Jee-Yeon Noh,Huikyong Lee,Sungmin Song,Nam Soon Kim,Wooseok Im,Manho Kim,Hyemyung Seo,Chul-Woong Chung,Jae-Woong Chang,Robert J Ferrante,Young-Jun Yoo,Hoon Ryu,Yong-Keun Jung
View all publications
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Product promise

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