AB118894

Anti-SCARA5 antibody

Name: Anti-SCARA5 antibody (ab118894) | Abcam
Brand: Abcam Limited
SKU: AB118894
Price: 630 USD
Availability: InStock

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(11 Publications)

Rabbit Polyclonal SCARA5 antibody. Suitable for ICC, ELISA, WB, IHC-P and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Human SCARA5.

View Alternative Names

UNQ2938/PRO28700, SCARA5, Scavenger receptor class A member 5, Scavenger receptor hlg

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCARA5 antibody (AB118894)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCARA5 antibody (AB118894)

ab118894t 5µg/ml, staining SCARA5 in Formalin-fixed, Paraffin-embedded Human Small intestine tissue by Immunohistochemistry.

Unknown

Western blot - Anti-SCARA5 antibody (AB118894)

All lanes:

Western blot - Anti-SCARA5 antibody (ab118894) at 1 µg/mL

All lanes:

Human liver tissue lysate

Predicted band size: 53 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ELISA, IHC-P, ICC, WB

applications

Immunogen

Synthetic Peptide within Human SCARA5. The exact immunogen used to generate this antibody is proprietary information.

Q6ZMJ2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "ICC-species-checked": "predicted", "ICC-species-dilution-info": "", "ICC-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCARA5 also known as scavenger receptor class A member 5 functions mechanically as a cell surface receptor involved in the endocytosis of iron-bound lipocalin-2. This protein has a mass of approximately 86 kDa. SCARA5 is expressed in various tissues including the placenta lung liver and prostate. It plays a role in binding and internalizing ligands leading to their transport into the cells where they are involved in further biological processes.

Biological function summary

SCARA5 plays a role in iron homeostasis as it modulates the cellular uptake of lipocalin-2 and its associated ferric-siderophore complexes. SCARA5 does not work alone; it operates as part of a complex involving ligands such as lipocalin-2 which can influence iron levels in cells and tissues. This interaction is necessary for maintaining proper iron balance and supporting cellular functions that rely on iron availability.

Pathways

SCARA5 is involved in the iron metabolism pathway and influences cellular iron uptake. This pathway interacts with other proteins like hepcidin and ferroportin which are essential for maintaining systemic iron balance. These interactions help to regulate iron absorption transport and storage within the body ensuring adequate iron is available for critical processes like red blood cell production and oxygen transport.

SCARA5 is associated with disorders like iron overload conditions and certain types of cancer. Abnormal SCARA5 expression or function may lead to disrupted iron homeostasis which can contribute to iron overload in tissues. Additionally SCARA5 expression has been linked to cancers such as hepatocellular carcinoma where it may interact with proteins like transferrin receptor to impact tumor growth and progression. Understanding its role in these conditions may provide insights into therapeutic targets and treatment strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1).

See full target information SCARA5

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

American journal of cancer research 15:426-438 PubMed40084377

2025

SCARA5 might be one potential marker for CC and promoted Ferroptosis by FTL.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjing Qi,Shunan Zhang

International journal of molecular sciences 25: PubMed39000462

2024

The Role of SCARA5 as a Potential Biomarker in Squamous Cell Carcinoma of the Lung.

Applications

Unspecified application

Species

Unspecified reactive species

Fidelis Andrea Flockerzi,Johannes Hohneck,Frank Langer,Wolfgang Tränkenschuh,Phillip Rolf Stahl

Diagnostics (Basel, Switzerland) 13: PubMed37443605

2023

SCARA5 Is Overexpressed in Prostate Cancer and Linked to Poor Prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Fidelis Andrea Flockerzi,Johannes Hohneck,Matthias Saar,Rainer Maria Bohle,Phillip Rolf Stahl

Cancer biology & therapy 23:1-13 PubMed35998226

2022

BMSC-derived exosomal lncRNA PTENP1 suppresses the malignant phenotypes of bladder cancer by upregulating SCARA5 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Shu-Cheng Liu,You-Han Cao,Li-Bo Chen,Ran Kang,Zhong-Xin Huang,Xin-Sheng Lu

International journal of molecular sciences 23: PubMed35008858

2021

New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Dominique de Seny,Dominique Baiwir,Elettra Bianchi,Gaël Cobraiville,Céline Deroyer,Christophe Poulet,Olivier Malaise,Geneviève Paulissen,Marie-Joëlle Kaiser,Jean-Philippe Hauzeur,Gabriel Mazzucchelli,Philippe Delvenne,Michel Malaise

Frontiers in oncology 11:666589 PubMed34150631

2021

The Novel Methylation Biomarker SCARA5 Sensitizes Cancer Cells to DNA Damage Chemotherapy Drugs in NSCLC.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Peng,Yan Liu,Xuehua Kong,Jie Xian,Lin Ye,Li Yang,Shuliang Guo,Yan Zhang,Lan Zhou,Tingxiu Xiang

Journal of nanobiotechnology 18:95 PubMed32660596

2020

Norepinephrine transporter-derived homing peptides enable rapid endocytosis of drug delivery nanovehicles into neuroblastoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yazan Haddad,Marketa Charousova,Hana Zivotska,Zbynek Splichal,Miguel Angel Merlos Rodrigo,Hana Michalkova,Sona Krizkova,Barbora Tesarova,Lukas Richtera,Petr Vitek,Kamila Stokowa-Soltys,David Hynek,Vedran Milosavljevic,Simona Rex,Zbynek Heger

Toxicology 419:40-54 PubMed30914192

2019

Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Radek Indra,Tereza Černá,Zbyněk Heger,Jan Hraběta,Marek Wilhelm,Simona Dostálová,Alžběta Lengálová,Markéta Martínková,Vojtěch Adam,Tomáš Eckschlager,Heinz H Schmeiser,Volker M Arlt,Marie Stiborová

Oncotarget 9:27974-27984 PubMed29963255

2018

Cancer cell death induced by ferritins and the peculiar role of their labile iron pool.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Carlos Cutrin,Diego Alberti,Caterina Bernacchioni,Silvia Ciambellotti,Paola Turano,Claudio Luchinat,Simonetta Geninatti Crich,Silvio Aime

Scientific reports 8:8867 PubMed29891921

2018

Prostate-Specific Membrane Antigen-Targeted Site-Directed Antibody-Conjugated Apoferritin Nanovehicle Favorably Influences In Vivo Side Effects of Doxorubicin.

Applications

Unspecified application

Species

Unspecified reactive species

Simona Dostalova,Hana Polanska,Marketa Svobodova,Jan Balvan,Olga Krystofova,Yazan Haddad,Sona Krizkova,Michal Masarik,Tomas Eckschlager,Marie Stiborova,Zbynek Heger,Vojtech Adam

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-SCARA5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCARA5 antibody (AB118894)

Western blot - Anti-SCARA5 antibody (AB118894)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Assay Kits

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (11)

Product promise