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AB76720

Anti-SCARA5 antibody

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(2 Publications)

Rabbit Polyclonal SCARA5 antibody. Suitable for WB, IHC-Fr and reacts with Mouse samples. Cited in 2 publications.

View Alternative Names

Scavenger receptor class A member 5, Scara5

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-Fr, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Alternative Products

Primary Antibodies

AB118894

Anti-SCARA5 antibody

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Complementary Products

Assay Kits

AB314386

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Secondary Antibodies

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARMET/ARP antibody [EPR29115-74] - BSA and Azide free (AB316936)

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Primary Antibodies

AB10558

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Primary Antibodies

AB46154

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Lab Essentials

Western blot - Anti-VEGFA antibody (AB46154)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCARA5 also known as scavenger receptor class A member 5 functions mechanically as a cell surface receptor involved in the endocytosis of iron-bound lipocalin-2. This protein has a mass of approximately 86 kDa. SCARA5 is expressed in various tissues including the placenta lung liver and prostate. It plays a role in binding and internalizing ligands leading to their transport into the cells where they are involved in further biological processes.
Biological function summary

SCARA5 plays a role in iron homeostasis as it modulates the cellular uptake of lipocalin-2 and its associated ferric-siderophore complexes. SCARA5 does not work alone; it operates as part of a complex involving ligands such as lipocalin-2 which can influence iron levels in cells and tissues. This interaction is necessary for maintaining proper iron balance and supporting cellular functions that rely on iron availability.

Pathways

SCARA5 is involved in the iron metabolism pathway and influences cellular iron uptake. This pathway interacts with other proteins like hepcidin and ferroportin which are essential for maintaining systemic iron balance. These interactions help to regulate iron absorption transport and storage within the body ensuring adequate iron is available for critical processes like red blood cell production and oxygen transport.

SCARA5 is associated with disorders like iron overload conditions and certain types of cancer. Abnormal SCARA5 expression or function may lead to disrupted iron homeostasis which can contribute to iron overload in tissues. Additionally SCARA5 expression has been linked to cancers such as hepatocellular carcinoma where it may interact with proteins like transferrin receptor to impact tumor growth and progression. Understanding its role in these conditions may provide insights into therapeutic targets and treatment strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1).
See full target information Scara5
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Investigative ophthalmology & visual science 64:22 PubMed36912597

2023

Ferritin But Not Iron Increases in Retina Upon Systemic Iron Overload in Diabetic and Iron-Dextran Injected Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Aina Bonet,Judit Pampalona,Eduard Jose-Cunilleras,Víctor Nacher,Jesús Ruberte

International journal of molecular sciences 19: PubMed30274263

2018

A Novel Naphthyridine Derivative, 3u, Induces Necroptosis at Low Concentrations and Apoptosis at High Concentrations in Human Melanoma A375 Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Qinghong Kong,Jianxin Lv,Shengjiao Yan,Kwen-Jen Chang,Guanlin Wang
View all publications
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Product promise

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