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AB36970

Anti-Scavenger Receptor BI + BII antibody

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(4 Publications)

Rabbit Polyclonal LIMPII antibody. Suitable for WB and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Mouse Scarb1 aa 200-300.

View Alternative Names

Lysosome membrane protein 2, 85 kDa lysosomal membrane sialoglycoprotein, Lysosome membrane protein II, Scavenger receptor class B member 2, LGP85, LIMP II, Scarb2, Srb1, Scarb1, Scavenger receptor class B member 1, SRB1, SR-BI

2 Images
Western blot - Anti-Scavenger Receptor BI + BII antibody (AB36970)
  • WB

Supplier Data

Western blot - Anti-Scavenger Receptor BI + BII antibody (AB36970)

All lanes:

Western blot - Anti-Scavenger Receptor BI + BII antibody (ab36970) at 1/1000 dilution

Lane 1:

wild-type mice

Lane 2:

SR-BI deficient mice

Predicted band size: 53 kDa

false

Western blot - Anti-Scavenger Receptor BI + BII antibody (AB36970)
  • WB

Unknown

Western blot - Anti-Scavenger Receptor BI + BII antibody (AB36970)

All lanes:

Western blot - Anti-Scavenger Receptor BI + BII antibody (ab36970) at 1/1000 dilution

All lanes:

80 µg of total mouse liver lysates

Predicted band size: 53 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Mouse Scarb1 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

Q61009

Specificity

ab36970 is specific for SR-BI and SR-BII.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Preservative: 0.02% Sodium azide Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Scavenger Receptor BI and BII also known as SR-BI and SR-BII play key roles in lipid metabolism. SR-BI is a protein that usually has a mass of approximately 82 kDa and SR-BII is a variant with a slightly different C-terminal sequence. Both isoforms express mainly in the liver and steroidogenic tissues. They serve as high-density lipoprotein (HDL) receptors facilitating lipid transfer and removal of cholesterol from these lipoproteins.
Biological function summary

These receptors maintain cholesterol homeostasis in the body. SR-BI and SR-BII function as part of the HDL complex enabling selective uptake of cholesterol esters into cells. This process supports steroidogenesis and cellular lipid distribution ensuring that cells meet their lipid needs effectively. Through these processes the receptors influence not only lipid metabolism but also bile acid synthesis.

Pathways

Scavenger Receptor BI and BII engage in cholesterol transport and reverse cholesterol transport pathways. These receptors work closely with proteins like apolipoprotein A-I and lecithin-cholesterol acyltransferase (LCAT) essential in these pathways. By mediating cholesterol trafficking from peripheral tissues back to the liver they play a significant role in maintaining systemic cholesterol balance.

Scavenger Receptor BI and BII link to atherosclerosis and liver disease. An imbalance in their activity can lead to altered cholesterol levels contributing to plaque formation in blood vessels. Additionally their dysfunction may relate to non-alcoholic fatty liver disease (NAFLD) where interactions with other proteins such as very low-density lipoprotein (VLDL) demonstrate an impact. Understanding these interactions helps in exploring potential therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting.
See full target information Scarb2

Additional targets

Scarb1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Biochimica et biophysica acta. Molecular and cell biology of lipids 1865:158612 PubMed31923467

2020

Endothelial lipase increases eNOS activating capacity of high-density lipoprotein.

Applications

Unspecified application

Species

Unspecified reactive species

Snježana Radulović,Benjamin Gottschalk,Gerd Hörl,Pablo Zardoya-Laguardia,Irene Schilcher,Seth Hallström,Nemanja Vujić,Kurt Schmidt,Markus Trieb,Wolfgang F Graier,Roland Malli,Dagmar Kratky,Gunther Marsche,Saša Frank

Science signaling 8:ra95 PubMed26396268

2015

Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Krishnakumar Balasubramanian,Akihiro Maeda,Janet S Lee,Dariush Mohammadyani,Haider Hussain Dar,Jian Fei Jiang,Claudette M St Croix,Simon Watkins,Vladimir A Tyurin,Yulia Y Tyurina,Katharina Klöditz,Anastassia Polimova,Valentyna I Kapralova,Zeyu Xiong,Prabir Ray,Judith Klein-Seetharaman,Rama K Mallampalli,Hülya Bayir,Bengt Fadeel,Valerian E Kagan

The Journal of steroid biochemistry and molecular 116:44-9 PubMed19406243

2009

Human macrophage cholesterol efflux potential is enhanced by HDL-associated 17beta-estradiol fatty acyl esters.

Applications

BL

Species

Human

Robert M Badeau,Jari Metso,Kristiina Wähälä,Matti J Tikkanen,Matti Jauhiainen

Journal of biochemistry 140:383-91 PubMed16873395

2006

Hydroxytyrosol administration enhances atherosclerotic lesion development in apo E deficient mice.

Applications

Unspecified application

Species

Unspecified reactive species

Sergio Acín,María A Navarro,José M Arbonés-Mainar,Natalia Guillén,Alfonso J Sarría,Ricardo Carnicer,Joaquín C Surra,Israel Orman,Jose C Segovia,Rafael de la Torre,María-Isabel Covas,Juan Fernández-Bolaños,Valentina Ruiz-Gutiérrez,Jesús Osada
View all publications
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Product promise

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