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AB17961

Anti-SCC112 antibody

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(1 Publication)

Rabbit Polyclonal SCC112 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PDS5A aa 1250-1300.

View Alternative Names

KIAA0648, PDS5, PIG54, PDS5A, Sister chromatid cohesion protein PDS5 homolog A, Cell proliferation-inducing gene 54 protein, Sister chromatid cohesion protein 112, SCC-112

1 Images
Western blot - Anti-SCC112 antibody (AB17961)
  • WB

Supplier Data

Western blot - Anti-SCC112 antibody (AB17961)

All lanes:

Western blot - Anti-SCC112 antibody (ab17961) at 0.04 µg/mL

Lane 1:

HeLa (Human cervix adenocarcinoma epithelial cell) whole cell lysate at 50 µg

Lane 2:

HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Predicted band size: 151 kDa

false

Exposure time: 30s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PDS5A aa 1250-1300. The exact immunogen used to generate this antibody is proprietary information.

Q29RF7

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.1% Sodium azide Constituents: PBS, 1.815% Tris, 1.764% Sodium citrate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCC112 also known as LAP1B is a protein involved in cellular structure and function processes. It has a molecular weight of approximately 75 kDa. SCC112 is expressed in various tissues including liver kidney and muscle. The protein is localized mainly to the inner nuclear membrane where it plays roles in maintaining nuclear structure and function. This localization position allows SCC112 to interact with a range of other nuclear proteins showing its involvement in broader cellular processes.
Biological function summary

The role of SCC112 is linked to its ability to regulate nuclear architecture and chromatin organization. It is part of the nuclear lamina-associated polypeptide family and is involved in complex formations with proteins responsible for maintaining nuclear stability. SCC112 influences the dynamics of chromatin interactions which impacts gene expression. Through these complex formations SCC112 helps in organizing the nuclear architecture which has downstream effects on various cellular activities.

Pathways

SCC112 acts within the nuclear envelope dynamics and chromatin organization pathways. It closely interacts with lamin proteins such as LMNA and LMNB1 which are essential for nuclear stability. These interactions facilitate the cohesion of nuclear structures and are necessary for appropriate chromatin organization. The involvement of SCC112 in these pathways suggests a broad influence on cellular replication and gene regulation. The precise regulation of chromatin architecture by SCC112 plays a significant part in cellular division processes and the maintenance of cellular integrity.

SCC112 has been associated with muscular dystrophy and certain types of cancer. Alterations in SCC112 expression levels can impact the balance of nuclear stability contributing to diseases such as Emery-Dreifuss muscular dystrophy where LMNA mutations are prevalent. Also abnormalities in SCC112 have been noted in certain cancer types suggesting a possible role in tumor progression. The connection with these diseases highlights the significant influence of SCC112 on nuclear integrity and cellular health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
See full target information PDS5A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Developmental cell 52:683-698.e7 PubMed32084359

2020

WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion.

Applications

Unspecified application

Species

Unspecified reactive species

Bente Benedict,Janne J M van Schie,Anneke B Oostra,Jesper A Balk,Rob M F Wolthuis,Hein Te Riele,Job de Lange
View all publications
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