AB185709

Anti-SCCPDH antibody

Name: Anti-SCCPDH antibody (ab185709) | Abcam
Brand: Abcam Limited
SKU: AB185709
Price: 495 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal SCCPDH antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SCCPDH aa 1-300.

View Alternative Names

CGI-49, SCCPDH, Saccharopine dehydrogenase-like oxidoreductase

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCCPDH antibody (AB185709)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCCPDH antibody (AB185709)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast cancer tissue labelling SCCPDH with ab185709 at 1/200. Magnification : 200x.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCCPDH antibody (AB185709)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human rectal cancer tissue labelling SCCPDH with ab185709 at 1/200. Magnification : 200x.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCCPDH antibody (AB185709)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat kidney tissue labelling SCCPDH with ab185709 at 1/200. Magnification : 200x.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCCPDH antibody (AB185709)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat testis tissue labelling SCCPDH with ab185709 at 1/200. Magnification : 200x.

Supplier Data

Western blot - Anti-SCCPDH antibody (AB185709)

All lanes:

Western blot - Anti-SCCPDH antibody (ab185709) at 1/500 dilution

Lane 1:

THP-1 extract

Lane 2:

PC-3 extract

Lane 3:

22RV-1 extract

Lane 4:

U251 extract

Lane 5:

A673 extract

Lane 6:

Mouse heart extract

Predicted band size: 47 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SCCPDH aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q8NBX0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCCPDH also known as Saccharopine Dehydrogenase-like Oxidoreductase is an enzyme with a molecular mass of approximately 59 kDa. This protein facilitates the conversion of saccharopine to lysine and α-ketoglutarate an important reaction in the metabolism of lysine. SCCPDH shows expression in various tissues with notable levels in the liver and brain. These locations indicate its essential role in metabolic processes across multiple cell types.

Biological function summary

SCCPDH participates in lysine degradation a critical pathway for the breakdown and utilization of lysine. The enzyme does not form part of a larger complex but works in coordination with other enzymes in the lysine catabolism pathway. SCCPDH ensures the efficient processing of lysine which is important for maintaining cellular amino acid balance and generating energy.

Pathways

SCCPDH integrates into the lysine degradation pathway and connects to the glutamate metabolism pathway. These pathways are interrelated since both share α-ketoglutarate as a metabolic intermediate. SCCPDH's activity influences the function of other enzymes like lysine-ketoglutarate reductase and glutamate dehydrogenase both of which help in maintaining amino acid homeostasis.

SCCPDH has links to certain metabolic disorders such as hyperlysinemia. In this condition alterations in SCCPDH function can lead to elevated lysine levels affecting normal metabolic processes. SCCPDH is also associated with neurodegenerative disorders often involving disruptions in amino acid metabolism. Disturbances in the SCCPDH pathway can impact proteins such as alpha-aminoadipic semialdehyde synthase further illustrating its relevance in disease contexts.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information SCCPDH

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

BMC pregnancy and childbirth 24:847 PubMed39709373

2024

Identification of hub genes, diagnostic model, and immune infiltration in preeclampsia by integrated bioinformatics analysis and machine learning.

Applications

Unspecified application

Species

Unspecified reactive species

Yihan Zheng,Zhuanji Fang,Xizhu Wu,Huale Zhang,Pengming Sun

British journal of cancer 128:748-759 PubMed36517551

2022

Molecular features and evolutionary trajectory of ASCL1 and NEUROD1 SCLC cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xuexi Zhang,Hao Wang,Wenxu Liu,Zengtuan Xiao,Zhenyi Ma,Zhenfa Zhang,Wenchen Gong,Jun Chen,Zhe Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SCCPDH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCCPDH antibody (AB185709)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCCPDH antibody (AB185709)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCCPDH antibody (AB185709)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCCPDH antibody (AB185709)

Western blot - Anti-SCCPDH antibody (AB185709)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Complementary Products

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Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise