AB115513

Anti-SCG10 antibody

Name: Anti-SCG10 antibody (ab115513) | Abcam
Brand: Abcam Limited
SKU: AB115513
Price: 630 USD
Availability: InStock

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(6 Publications)

Goat Polyclonal SCG10 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human STMN2 aa 1-50.

View Alternative Names

SCG10, SCGN10, STMN2, Stathmin-2, Superior cervical ganglion-10 protein, Protein SCG10

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCG10 antibody (AB115513)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCG10 antibody (AB115513)

ab115513 at 5ug/ml staining SCG10 in Formalin-fixed, Paraffin-embedded Human small intestine (myenteric plexus) tissue Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Unknown

Western blot - Anti-SCG10 antibody (AB115513)

Primary incubation : 1 hour

All lanes:

Western blot - Anti-SCG10 antibody (ab115513) at 1 µg/mL

All lanes:

Human brain lysate (in RIPA buffer) at 35 µg

Predicted band size: 21 kDa

true

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCG10 antibody (AB115513)

ab115513 at 5ug/ml staining SCG10 in Formalin-fixed, Paraffin-embedded Human brain (cortex) tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human STMN2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q93045

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCG10 also known as Superior Cervical Ganglion 10 or Stathmin-like 2 functions mechanically as a microtubule destabilizing protein. It belongs to a larger family known as the stathmin family and has a molecular mass of approximately 21 kDa. Expression of SCG10 is mostly in the central nervous system with high levels found in neurons particularly during development and growth of axons. This specific distribution suggests a specialized role in neural processes.

Biological function summary

SCG10 plays an important role in neural growth by promoting microtubule dynamics. Its activity helps to regulate the assembly and disassembly of microtubules essential for maintaining the structure and function of growing neurons. SCG10 is not typically part of a larger complex; instead it acts alone to perform its microtubule-related tasks. This independent action allows for precise control over neural development and regeneration processes.

Pathways

SCG10 contributes significantly to pathways involving neural development and axonal transport. It frequently participates in the microtubule-dependent pathways that facilitate rapid changes in axonal architecture. Linked proteins such as tubulin and the stathmin family proteins collaborate in these pathways to modulate microtubule stability. This coordination underpins the efficient transport of cellular components necessary for nerve cell function and response.

SCG10 has associations with neurodegenerative conditions and neuroblastoma. Abnormal SCG10 expression or function can influence neuron health and survival potentially contributing to disorders like Alzheimer's disease. Furthermore alteration in SCG10 levels relates to neuroblastoma because of its role in neural cell growth. Its relationship with the protein Tau in neurodegenerative conditions highlights its importance in maintaining neuronal integrity and function.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).

See full target information STMN2

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 28:76 PubMed35768768

2022

Upregulated lncARAT in Schwann cells promotes axonal regeneration by recruiting and activating proregenerative macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Yin,Yaofa Lin,Peilin Wang,Jun Zhou,Haodong Lin

Neuron 110:1671-1688.e6 PubMed35294901

2022

Loss of mouse Stmn2 function causes motor neuropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Irune Guerra San Juan,Leslie A Nash,Kevin S Smith,Marcel F Leyton-Jaimes,Menglu Qian,Joseph R Klim,Francesco Limone,Alexander B Dorr,Alexander Couto,Greta Pintacuda,Brian J Joseph,D Eric Whisenant,Caroline Noble,Veronika Melnik,Deirdre Potter,Amie Holmes,Aaron Burberry,Matthijs Verhage,Kevin Eggan

Islets 14:40-57 PubMed34923907

2021

Misrouting of glucagon and stathmin-2 towards lysosomal system of α-cells in glucagon hypersecretion of diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Farzad Asadi,Savita Dhanvantari

Biology 10: PubMed34439938

2021

Vitamin D Is Necessary for Murine Gastric Epithelial Homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Ifrah Ismail Ali,Iltaf Shah,Sayed Marzouk,Sherif M Karam,Asma Al Menhali

Folia neuropathologica 59:50-66 PubMed33969677

2021

Inhibition of ASC enhances the protective role of salvianolic acid A in traumatic brain injury via inhibition of inflammation and recovery of mitochondrial function.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wang,Chao Xu,Kunhu Zhang,Jianjun Shi,Zhenyang Liu,Xinxing Wang,Min Guo,Jiannan Lv,Xinmin Ding

Frontiers in endocrinology 11:29 PubMed32117057

2020

Stathmin-2 Mediates Glucagon Secretion From Pancreatic α-Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Farzad Asadi,Savita Dhanvantari

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SCG10 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCG10 antibody (AB115513)

Western blot - Anti-SCG10 antibody (AB115513)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCG10 antibody (AB115513)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

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