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AB181853

Anti-SCGB3A2 antibody [EPR11463]

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(14 Publications)

Rabbit Recombinant Monoclonal SCGB3A2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 14 publications.

View Alternative Names

PNSP1, UGRP1, UNQ566/PRO1128, SCGB3A2, Secretoglobin family 3A member 2, Pneumo secretory protein 1, Uteroglobin-related protein 1, PnSP-1

4 Images
Immunocytochemistry/ Immunofluorescence - Anti-SCGB3A2 antibody [EPR11463] (AB181853)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SCGB3A2 antibody [EPR11463] (AB181853)

Immunocytochemistry/Immunofluorescence analysis of A549 (human lung carcinoma) labelling SCGB3A2 with purified ab181853 at 1/500. Cells were fixed with 100% methanol. An Alexa Fluor® 488-conjugated goat anti-rabbit IgG (1/1000) was used as the secondary antibody (ab150077). Nuclei counterstained with DAPI (blue).

Control : PBS only

Immunocytochemistry/ Immunofluorescence - Anti-SCGB3A2 antibody [EPR11463] (AB181853)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SCGB3A2 antibody [EPR11463] (AB181853)

Immunofluorescent analysis of A549 cells (paraformaldehyde-fixed, 4%) labeling SCGB3A2 with ab181853 at 1/500 dilution followed by Goat anti rabbit IgG Alexa Fluor 555) secondary at 1/200 dilution and counter-stained with DAPI.

Western blot - Anti-SCGB3A2 antibody [EPR11463] (AB181853)
  • WB

Supplier Data

Western blot - Anti-SCGB3A2 antibody [EPR11463] (AB181853)

All lanes:

Western blot - Anti-SCGB3A2 antibody [EPR11463] (ab181853) at 1/1000 dilution

All lanes:

Human SCGB3A2 recombinant protein at 0.01 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L) HRP at 1/1000 dilution

Predicted band size: 10 kDa

false

Western blot - Anti-SCGB3A2 antibody [EPR11463] (AB181853)
  • WB

Supplier Data

Western blot - Anti-SCGB3A2 antibody [EPR11463] (AB181853)

All lanes:

Western blot - Anti-SCGB3A2 antibody [EPR11463] (ab181853) at 1/1000 dilution

All lanes:

Calu 3 cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L) HRP at 1/1000 dilution

Predicted band size: 10 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11463

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.01% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCGB3A2 also recognized as uteroglobin-related protein 1 (UGRP1) is a small secreted protein with a molecular mass around 10 kDa. It is mainly expressed in the epithelial cells of the respiratory tract notably the lungs where it plays a role in modulating immune responses. In terms of structure SCGB3A2 shares similarities with other secretoglobin family members indicating conserved functional motifs. Its expression is tightly regulated and reflects its involvement in maintaining respiratory health.
Biological function summary

SCGB3A2 acts as an anti-inflammatory agent that modulates immune cell activity and cytokine signaling within the lungs. It does not form known protein complexes but interacts with other immune mediators to reduce inflammation. Furthermore SCGB3A2 has roles in cell proliferation and repair mechanisms especially in response to lung injury. Its interaction with various cytokines supports tissue regeneration and homeostasis making it important in maintaining lung function.

Pathways

SCGB3A2 interacts in immune regulatory pathways significant in lung tissue. Notably it participates in pathways related to the suppression of inflammatory cytokine production and has a working relationship with proteins such as IL-10 and TGF-beta that mitigate excessive immune reactions. These interactions exhibit roles in the regulation of immune responses and the promotion of tissue repair making SCGB3A2 part of important biological processes that protect lung integrity.

SCGB3A2 is linked to conditions such as asthma and chronic obstructive pulmonary disease (COPD) where inflammation plays an important role. Alterations in SCGB3A2 expression correlate with disease severity suggesting its potential as a biomarker. Its relationship with TGF-beta is of particular interest as dysregulation of this protein contributes to fibrotic changes in lung tissue. Studies continue to explore how modulating SCGB3A2 levels may influence disease progression and treatment outcomes in inflammatory lung disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Secreted cytokine-like protein (PubMed : 12847263). Binds to the scavenger receptor MARCO (PubMed : 12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed : 12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed : 24213919). Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung (PubMed : 24213919). May play a role in fetal lung development and maturation (PubMed : 24213919). Promotes branching morphogenesis during early stages of lung development (PubMed : 24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity).
See full target information SCGB3A2
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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 13: PubMed40722696

2025

Role of BMPR2 Mutation in Lung Organoid Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Simin Jiang,Dian Chen,Liangliang Tian,Zihang Pan,Huanyu Long,Lanhe Chu,Weijing Kong,Qiyang Yao,Xiaojing Ma,Yun Zhao,Kai Wang,Yahong Chen

Molecular medicine (Cambridge, Mass.) 31:231 PubMed40495135

2025

Cellular imbalance in proximal and distal lung of CFTR sheep in utero and at birth.

Applications

Unspecified application

Species

Unspecified reactive species

Shih-Hsing Leir,Svyatoslav Tkachenko,Alekh Paranjapye,Arnaud J Van Wettere,Jenny L Kerschner,Iuri Viotti Perisse,Cheyenne M Marriott,Tayler Patrick,Ying Liu,Kenneth L White,Irina A Polejaeva,Ann Harris

Biomedicines 13: PubMed40299508

2025

Lung Organoids from hiPSCs Can Be Efficiently Transduced by Recombinant Adeno-Associated Viral and Adenoviral Vectors.

Applications

Unspecified application

Species

Unspecified reactive species

Lyubava Belova,Anna Demchenko,Anastasia Erofeeva,Konstantin Kochergin-Nikitsky,Olga Zubkova,Olga Popova,Tatiana Ozharovskaia,Diana Salikhova,Anna Efremova,Alexander Lavrov,Svetlana Smirnikhina

Biochemical genetics 63:5394-5414 PubMed39656403

2024

Inflammatory Signaling Induces Mitochondrial Dysfunction and Neuronal Death in Traumatic Brain Injury via Downregulation of OXPHOS Genes.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Dong,Hui Zhang,Lei Cai,Quanyi Ye,Heping Wang,Bo Liu,Wenhu Zhang,Junxin Li

Theranostics 14:6185-6201 PubMed39431015

2024

Spatial transcriptomic sequencing reveals immune microenvironment features of granulomas in lung and omentum.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaochen Qiu,Pengfei Zhong,Liang Yue,Chaofan Li,Zhimin Yun,Guangqian Si,Mengfan Li,Zhi Chen,Yingxia Tan,Pengtao Bao

Cells 12: PubMed37887346

2023

Differential Transcriptomic Signatures of Small Airway Cell Cultures Derived from IPF and COVID-19-Induced Exacerbation of Interstitial Lung Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Katie Uhl,Shreya Paithankar,Dmitry Leshchiner,Tara E Jager,Mohamed Abdelgied,Bhavna Dixit,Raya Marashdeh,Dewen Luo-Li,Kaylie Tripp,Angela M Peraino,Maximiliano Tamae Kakazu,Cameron Lawson,Dave W Chesla,Ningzhi Luo-Li,Edward T Murphy,Jeremy Prokop,Bin Chen,Reda E Girgis,Xiaopeng Li

International journal of molecular sciences 24: PubMed37047264

2023

Airway and Lung Organoids from Human-Induced Pluripotent Stem Cells Can Be Used to Assess CFTR Conductance.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Demchenko,Ekaterina Kondrateva,Vyacheslav Tabakov,Anna Efremova,Diana Salikhova,Tatiana Bukharova,Dmitry Goldshtein,Maxim Balyasin,Natalia Bulatenko,Elena Amelina,Alexander Lavrov,Svetlana Smirnikhina

Cell 185:4841-4860.e25 PubMed36493756

2022

A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates.

Applications

Unspecified application

Species

Unspecified reactive species

Peng He,Kyungtae Lim,Dawei Sun,Jan Patrick Pett,Quitz Jeng,Krzysztof Polanski,Ziqi Dong,Liam Bolt,Laura Richardson,Lira Mamanova,Monika Dabrowska,Anna Wilbrey-Clark,Elo Madissoon,Zewen Kelvin Tuong,Emma Dann,Chenqu Suo,Isaac Goh,Masahiro Yoshida,Marko Z Nikolić,Sam M Janes,Xiaoling He,Roger A Barker,Sarah A Teichmann,John C Marioni,Kerstin B Meyer,Emma L Rawlins

Developmental cell 57:1598-1614.e8 PubMed35679862

2022

R-SPONDIN2 mesenchymal cells form the bud tip progenitor niche during human lung development.

Applications

Unspecified application

Species

Unspecified reactive species

Renee F C Hein,Joshua H Wu,Emily M Holloway,Tristan Frum,Ansley S Conchola,Yu-Hwai Tsai,Angeline Wu,Alexis S Fine,Alyssa J Miller,Emmanuelle Szenker-Ravi,Kelley S Yan,Calvin J Kuo,Ian Glass,Bruno Reversade,Jason R Spence

Clinical and translational medicine 12:e850 PubMed35652821

2022

Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Han,Feifei Zhang,Yu Liu,Jie Yu,Qianyue Zhang,Xiaoping Ye,Huaidong Song,Cuixia Zheng,Bing Han
View all publications
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