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AB90238

Anti-SCGF antibody [MM0533-6D5]

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(2 Publications)

Mouse Monoclonal SCGF antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CLEC11A.

View Alternative Names

CLECSF3, LSLCL, SCGF, CLEC11A, C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Osteolectin, Stem cell growth factor, p47

1 Images
Western blot - Anti-SCGF antibody [MM0533-6D5] (AB90238)
  • WB

Supplier Data

Western blot - Anti-SCGF antibody [MM0533-6D5] (AB90238)

All lanes:

Western blot - Anti-SCGF antibody [MM0533-6D5] (ab90238) at 1/500 dilution

All lanes:

Human placenta tissue lysate

Predicted band size: 35 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0533-6D5

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CLEC11A.

Q9Y240

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Alternative Products

Primary Antibodies

AB238830

Anti-SCGF antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGF antibody (AB238830)

  • 0
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Complementary Products

Assay Kits

AB314388

Human SCGF ELISA Kit

Sandwich ELISA - Human SCGF ELISA Kit (AB314388)

  • 0
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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB68672

Anti-Neutrophil Elastase antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neutrophil Elastase antibody (AB68672)

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Primary Antibodies

AB26

Anti-p53 antibody [PAb 240]

KO Validated|Lab Essentials

Western blot - Anti-p53 antibody [PAb 240] (AB26)

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Primary Antibodies

AB22552

Anti-Sp7 / Osterix antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sp7 / Osterix antibody (AB22552)

  • 5
  • 24
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Stem Cell Growth Factor (SCGF) also known as C-type lectin domain family 11 member A (CLEC11A) is a glycoprotein with a mass around 38 kDa. It mechanically functions by promoting mitogenic and survival activities on hematopoietic progenitors which are essential for blood cell formation. SCGF is mainly expressed in the bone marrow as well as in several other tissues such as the pancreas and liver where it plays significant roles.
Biological function summary

SCGF plays a significant role in the development and regulation of the hematopoietic system. It supports the proliferation and differentiation of a variety of blood cell lineages. SCGF does not belong to a complex but interacts with other soluble factors like cytokines and growth factors to exert its functions. It enhances the actions of colony-stimulating factors emphasizing its role in hematopoiesis.

Pathways

SCGF is important in the regulation of the hematopoietic growth pathways. It is involved in the cytokine-cytokine receptor interaction pathway which assists in signaling and communication between cells. SCGF shows interactions with proteins like FLT3 which play a role in the development and survival of blood cell precursors. This intricate network bolsters the adaptive and innate immune systems by promoting the production and function of necessary blood cells.

Disruptions in SCGF activity can influence both hematological and autoimmune disorders. Alterations in SCGF expression have connections to leukemia where abnormal proliferation of blood cells occurs. Additionally its dysregulation may contribute to autoimmune diseases where the immune system mistakenly attacks the body. In these contexts SCGF relates with the cytokine IL-6 which is also involved in immune responses and inflammation further underlining SCGF's influence on disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed : 27976999). Important for repair and maintenance of adult bone (By similarity).
See full target information CLEC11A
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Genes 13: PubMed35456465

2022

Transcriptome Profile of Membrane and Extracellular Matrix Components in Ligament-Fibroblastic Progenitors and Cementoblasts Differentiated from Human Periodontal Ligament Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Seyoung Mun,Seong Min Kim,Min-Jeong Choi,Young-Joo Jang

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 75:298-308 PubMed27546031

2016

Genetic Analysis of Giant Cell Lesions of the Maxillofacial and Axial/Appendicular Skeletons.

Applications

Unspecified application

Species

Unspecified reactive species

Zachary S Peacock,Joseph H Schwab,William C Faquin,Francis J Hornicek,Yair Benita,David H Ebb,Leonard B Kaban
View all publications
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Product promise

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