Rabbit Polyclonal SCGN/Secretagogin antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SCGN aa 50-250.
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- Science (New York, N.Y.) 374:eabj66412021Mouse and human share conserved transcriptional programs for interneuron development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYingchao Shi,Mengdi Wang,Da Mi,Tian Lu,Bosong Wang,Hao Dong,Suijuan Zhong,Youqiao Chen,Le Sun,Xin Zhou,Qiang Ma,Zeyuan Liu,Wei Wang,Junjing Zhang,Qian Wu,Oscar Marín,Xiaoqun WangPubMed 34882453
- The Journal of comparative neurology 526:877-8982017Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.Applications:Unspecified applicationReactive species:MouseFarid N Garas,Eszter Kormann,Rahul S Shah,Federica Vinciati,Yoland Smith,Peter J Magill,Andrew SharottPubMed 29218729
- eLife 5:2016Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFarid N Garas et. al.PubMed 27669410
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SCGN aa 50-250. The exact immunogen used to generate this antibody is proprietary information. Database link O76038
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
| Cow | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/3000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/500 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
Associated Products
Select an associated product type
4 products for Alternative Product
Target data
Alternative names
SECRET, SCGN, Secretagogin
Recommended products
Rabbit Polyclonal SCGN/Secretagogin antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SCGN aa 50-250.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SCGN aa 50-250. The exact immunogen used to generate this antibody is proprietary information. Database link O76038
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
ab111871 is purified by antigen-affinity chromatography.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SCGN also known as Secretagogin is a calcium-binding protein with a molecular weight of approximately 33 kDa. It belongs to the family of EF-hand superfamily proteins which is known for its role in various cellular processes. Secretagogin predominantly expresses in neuroendocrine tissues such as the pancreas and central nervous system where it binds calcium and possibly modulates its signaling. It has drawn interest due to its distinctive expression pattern and potential role in regulated secretion.
- Biological function summary
The role of Secretagogin extends beyond simple calcium binding. It participates in managing cytoskeleton dynamics through its ability to bind calcium impacting processes like vesicle trafficking. Although not part of a standard protein complex Secretagogin interacts with other cytoskeletal proteins and may influence the release of hormones. Its role in neurotransmission and insulin secretion showcases its significance in both the nervous and endocrine systems.
- Pathways
Secretagogin interacts within signaling networks such as the calcium-signaling and insulin-secretion pathways. It has established relationships with other proteins like actin influencing cellular architecture and trafficking. Through these pathways Secretagogin appears instrumental in processes involving rapid response times such as neurotransmitter release or hormone secretion often acting in conjunction with or supporting other calcium-binding proteins.
- Associated diseases and disorders
Secretagogin has connections to diabetes and certain neuroendocrine tumors. Its involvement in insulin secretion makes it relevant in the context of diabetes where it might interact with malfunctioning insulin-related proteins. Additionally in neuroendocrine tumors altered Secretagogin expression could be linked with oncogenic processes as it shares pathways with proteins involved in cell-cycle regulation. Understanding these associations can aid in identifying potential therapeutic targets or biomarkers for these diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-SCGN/Secretagogin antibody (ab111871)
12% SDS PAGE
All lanes: Western blot - Anti-SCGN/Secretagogin antibody (ab111871) at 1/1000 dilution
All lanes: HeLa whole cell lysate at 30 µg
Predicted band size: 32 kDa, 44 kDa
Immunocytochemistry/ Immunofluorescence - Anti-SCGN/Secretagogin antibody (ab111871)
ab111871 at 1/200 dilution staining SCGN/Secretagogin in methanol-fixed HeLa cells by Immunofluorescence. The lower image is costained with Hoechst 33342.
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