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AB223055

Anti-SCIN antibody

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(2 Publications)

Rabbit Polyclonal SCIN antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SCIN aa 550-750.

View Alternative Names

KIAA1905, SCIN, Scinderin, Adseverin

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-SCIN antibody (AB223055)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SCIN antibody (AB223055)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for SCIN (green) using ab223055 at 1/100 dilution in ICC/IF, followed by Alexa Fluor® 488-conjugated Goat Anti-Rabbit IgG(H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SCIN aa 550-750. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6U3

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Alternative Products

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AB191396

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
>95% pure
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCIN also known as scinderin or adseverin is an actin-severing protein involved in cytoskeletal dynamics. This protein has a mass of approximately 80 kDa. SCIN is expressed in a variety of tissues including neural hematopoietic and endocrine systems. Its mechanical function includes binding to filamentous actin and promoting severing which helps in the reorganization of the actin cytoskeleton. This activity is calcium-dependent making SCIN responsive to intracellular calcium levels.
Biological function summary

SCIN influences cellular processes like secretion motility and division. SCIN belongs to the gelsolin/villin family of actin-modulating proteins and often acts within a protein complex to disassemble actin filaments. It regulates exocytosis by modulating actin dynamics near the plasma membrane especially in cells such as chromaffin cells and platelets. Its ability to rearrange actin filaments is important for maintaining cellular homeostasis and responsive adaptation to environmental changes.

Pathways

SCIN is involved in the cytoskeletal signaling and calcium signaling pathways. It plays a role in actin filament dynamics and is related to other actin-binding proteins like gelsolin and cofilin through these pathways. SCIN interacts with phosphatidylinositol 45-bisphosphate (PIP2) and calcium ions which are important for its activity in cellular signaling networks. These pathways optimize how cells react to stimuli by altering their shape and function.

SCIN has been linked to neurodegenerative disorders and cancer. Disruptions in SCIN function can contribute to diseases such as Alzheimer's where abnormal actin dynamics impact neuronal function. SCIN is also associated with certain cancers through its role in cell migration and metastasis. The protein may interact with tau in neurodegenerative disorders and it interacts with proteins like cortactin in cancer progression influencing cellular motility.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed : 26365202, PubMed : 8547642). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed : 11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed : 11568009).
See full target information SCIN
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Biomaterials research 29:0244 PubMed40873954

2025

Engineered Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Mitigate Liver Fibrosis by Delivering USP10 to Reprogram Macrophage Phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Siyuan Tian,Xia Zhou,Linhua Zheng,Jingyi Liu,Miao Zhang,Shuoyi Ma,Xiaohong Zheng,Guanya Guo,Ruobing Ju,Fangfang Yang,Yansheng Liu,Bo Li,Yinan Hu,Erzhuo Xia,Rui Su,Keshuai Sun,Lina Cui,Changcun Guo,Xinmin Zhou,Jingbo Wang,Yulong Shang,Ying Han

Science advances 9:eadf1130 PubMed37540756

2023

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.

Applications

Unspecified application

Species

Unspecified reactive species

Byron Chan,Michael Glogauer,Yongqiang Wang,Jeffrey Wrana,Kin Chan,Frank Beier,Supinder Bali,Boris Hinz,Justin Parreno,Sajjad Ashraf,Rita Kandel
View all publications
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Product promise

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