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AB65160

Anti-SCN11A antibody

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(1 Publication)

Rabbit Polyclonal SCNBA antibody. Suitable for WB, IHC-P, ICC/IF, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SCN11A.

View Alternative Names

SCN12A, SNS2, SCN11A, Sodium channel protein type 11 subunit alpha, Peripheral nerve sodium channel 5, Sensory neuron sodium channel 2, Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.9, hNaN, PN5

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-Fr, ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human SCN11A. The exact immunogen used to generate this antibody is proprietary information.

Q9UI33

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Alternative Products

Primary Antibodies

AB198859

Anti-SCN11A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCN11A antibody (AB198859)

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Complementary Products

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Primary Antibodies

AB53724

Anti-pan Sodium Channel antibody

Western blot - Anti-pan Sodium Channel antibody (AB53724)

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Primary Antibodies

AB93616

Anti-Nav1.8/SCN10A antibody [S134]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nav1.8/SCN10A antibody [S134] (AB93616)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCN11A also known as Nav1.9 is a voltage-gated sodium channel expressed in peripheral sensory neurons particularly in the dorsal root ganglion and trigeminal ganglion. The protein has an approximate mass of 207 kDa. SCN11A plays an important role in generating and propagating action potentials by allowing sodium ions to enter the cell. This ion influx is important for neuronal excitability and pain signal transmission. Expression of SCN11A is known to be increased in response to certain inflammatory processes and may contribute to pain perception.
Biological function summary

SCN11A contributes to the modulation of neuronal excitability and pain pathways. The channel participates in adjusting the resting membrane potential and firing threshold of neurons. It is hypothesized to function independently rather than as part of a larger protein complex. SCN11A influences the intensity and duration of pain signals affecting the perception of both acute and chronic pain. Its regulation is essential for proper sensory neuron functioning.

Pathways

SCN11A is involved in the nociceptive pain pathway which is responsible for the sensation of pain due to tissue injury. It interacts with other sodium channels such as Nav1.8 to fine-tune pain signaling under various physiological and pathological conditions. Additionally SCN11A is linked to the inflammatory response pathway where its expression can be modulated by pro-inflammatory cytokines. This interaction underlines the channel’s role in mediating neuropathic and inflammatory pain.

SCN11A is associated with neuropathic pain and familial episodic pain syndrome. Mutations in SCN11A can lead to altered channel function resulting in enhanced pain sensitivity or spontaneous pain episodes. The channel's dysfunction is also observed in conditions involving Nav1.7 another sodium channel implicated in pain disorders. Understanding the role of SCN11A in these conditions can provide insights into therapeutic targets for pain management and relief.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed : 10580103, PubMed : 12384689, PubMed : 24036948, PubMed : 24776970, PubMed : 25791876, PubMed : 26645915). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system (PubMed : 24036948, PubMed : 24776970, PubMed : 25791876, PubMed : 26645915). Also involved in rapid BDNF-evoked neuronal depolarization (PubMed : 12384689).
See full target information SCN11A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Reproductive biology and endocrinology : RB&E 7:71 PubMed19607678

2009

Molecular and functional characterization of voltage-gated sodium channels in human sperm.

Applications

ICC/IF

Species

Human

Francisco M Pinto,Cristina G Ravina,Manuel Fernández-Sánchez,Manuel Gallardo-Castro,Antonio Cejudo-Román,Luz Candenas
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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