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AB230093

Anti-Scn2b antibody

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(1 Publication)

Rabbit Polyclonal SCN2B antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SCN2B aa 1-200.

View Alternative Names

UNQ326/PRO386, SCN2B, Sodium channel regulatory subunit beta-2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Scn2b antibody (AB230093)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Scn2b antibody (AB230093)

Paraffin-embedded human brain tissue stained for Scn2b using ab230093 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SCN2B aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

O60939

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Scn2b protein also known as sodium channel beta-2 subunit has a molecular weight of approximately 23 kDa. It plays an essential role in modulating the activity and function of voltage-gated sodium channels. This protein is primarily expressed in the central and peripheral nervous system where it assists in the regulation of sodium ion flow across the cell membrane. Scn2b serves as an auxiliary subunit interacting with the alpha subunits to influence channel gating kinetics and surface expression.
Biological function summary

Scn2b contributes to the electrical excitability of neurons by stabilizing the sodium channel complex on the neuronal surface. It forms part of a larger complex that is important for the propagation of action potentials. The presence of Scn2b affects the conduction velocity and firing patterns of neurons and can have effects on synaptic transmission. These functions underline its role in maintaining normal neural communication and processing in the nervous system.

Pathways

Scn2b is involved in excitable cell pathways particularly those regulating neuronal action potential and transmission. It closely interacts with the SCN family of sodium channel alpha subunits such as SCN1A and SCN8A which are critical for the initiation and propagation of action potentials. Additionally Scn2b takes part in pathways linked to neuronal growth and development where it influences the morphogenic signaling due to its interaction with cell adhesion molecules.

Scn2b associates with conditions like epilepsy and cardiac arrhythmia. Its interaction with sodium channel alpha subunits is significant in the pathogenesis of epilepsy where altered sodium channel function can lead to abnormal neuronal firing and seizures. Additionally Scn2b's role in influencing sodium channel expression and function links it to cardiac arrhythmias involving abnormal heart rhythms. Aberrations in Scn2b function or expression can affect cardiac sodium channel SLN5A contributing to these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (PubMed : 19808477, PubMed : 23559163, PubMed : 26894959, PubMed : 30765605, PubMed : 30765606, PubMed : 35277491, PubMed : 36823201). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed : 19808477, PubMed : 23559163, PubMed : 26894959). The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed : 19808477, PubMed : 23559163). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN2A/Nav1.3, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (PubMed : 19808477, PubMed : 23559163, PubMed : 26894959, PubMed : 30765605, PubMed : 30765606, PubMed : 35277491, PubMed : 36823201).
See full target information SCN2B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 16:11668-11682 PubMed39133152

2024

Solamargine acts as an antiviral by interacting to MZF1 and targeting the core promoter of the hepatitis B virus gene.

Applications

Unspecified application

Species

Unspecified reactive species

Wenwen Chen,Xinrui Zhao,Yingli Huang,Kai Lu,Yuan Li,Xiaofang Li,Hui Ding,Xiuling Li,Suofeng Sun
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