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AB254861

Anti-SCN3B antibody

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Rabbit Polyclonal SCN3B antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SCN3B aa 50-200.

View Alternative Names

KIAA1158, SCN3B, Sodium channel regulatory subunit beta-3

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-SCN3B antibody (AB254861)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SCN3B antibody (AB254861)

PFA fixed, Triton X-100 permeabilized U-2 OS (Human bone osteosarcoma epithelial cell line) cells labeling SCN3B using ab254861 at 4µg/ml (green) in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SCN3B aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q9NY72

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Complementary Products

Proteins & Peptides

AB222957

Recombinant Human SCN3B protein (His tag C-Terminus)

SDS-PAGE - Recombinant Human SCN3B protein (His tag C-Terminus) (AB222957)

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Primary Antibodies

AB254868

Anti-ZIP-3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-3 antibody (AB254868)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB254839

Anti-SERP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SERP1 antibody (AB254839)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cynomolgus monkey": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCN3B also known as sodium channel beta-3 subunit or NaVβ3 is a protein component with a mass of approximately 21 kDa. It participates actively in the regulation of sodium ion channels which are essential for the transmission of electrical signals in the nervous system and heart. SCN3B is important for maintaining the proper functioning of various sodium channels by modulating their gating properties. It is mostly expressed in the central nervous system with significant presence noted in heart tissues. Its expression pattern suggests a role in areas requiring precise signal modulation.
Biological function summary

SCN3B influences the electrical excitability of neuronal and cardiac cells by serving as an auxiliary subunit of the voltage-gated sodium channels complex. It plays a supportive role by affecting the trafficking and functional integration of the alpha subunits which are key components for channel functionality. Through its involvement with these complexes SCN3B contributes to maintaining the balance and modulation of sodium ion flow across cell membranes which is critical for proper excitability in both neurons and myocytes.

Pathways

SCN3B's function integrates into pathways regulating electrical signaling in nerve and muscle tissues. Notably it participates in the cardiac action potential pathway ensuring that the rapid depolarization necessary for cardiac muscle contraction occurs effectively. It is also involved in the neuronal action potential signaling working closely with other proteins such as SCN1A and SCN5A which are alpha subunits of the sodium channels. These pathways highlight SCN3B's role in facilitating accurate and timely propagation of action potentials.

SCN3B abnormalities associate with conditions like Brugada syndrome and certain epileptic disorders. In Brugada syndrome a cardiac condition leading to sudden cardiac arrest SCN3B mutations can affect the sodium channels impairing signal conduction and increasing risk for arrhythmias. It has connections to SCN5A another sodium channel subunit implicated in similar cardiac disorders. For epilepsy disruptions in SCN3B can alter the excitability of neurons resulting in seizure development. By its association with key proteins SCN3B holds significant implications for understanding the molecular basis of these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed : 20558140, PubMed : 21051419). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation of the channel and increasing the fraction of channels operating in the fast gating mode (By similarity). Modulates the activity of SCN5A/Nav1.5 (PubMed : 20558140, PubMed : 21051419, PubMed : 24567321, PubMed : 31950564). Could also regulate the atypical sodium channel SCN7A/Nav2.1 (PubMed : 35301303). Modulates the activity of SCN10A/Nav1.8, regulating its oligomerization and accelerating the recovery from inactivation (PubMed : 14975698).
See full target information SCN3B
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