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AB65165

Anti-SCN4A antibody

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Rabbit Polyclonal SCN4A antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SCN4A.

View Alternative Names

Sodium channel protein type 4 subunit alpha, SkM1, Sodium channel protein skeletal muscle subunit alpha, Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4, SCN4A

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human SCN4A. The exact immunogen used to generate this antibody is proprietary information.

P35499

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Reactivity data

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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SCN4A gene encodes the Nav1.4 protein also known as the sodium channel voltage-gated type IV alpha subunit. Nav1.4 is a voltage-gated sodium channel with a molecular weight around 250 kDa. It mainly facilitates the rapid influx of sodium ions into skeletal muscle cells which is important for the initiation and conduction of action potentials. Expression of Nav1.4 is strong in skeletal muscle tissues playing an important role in muscle excitability and contraction. It serves as a pivotal point in the regulation of skeletal muscle function.
Biological function summary

Nav1.4 is essential in generating and propagating action potentials necessary for muscle contraction. This protein functions as part of a complex that includes beta subunits that help modulate its properties. The precise gating and ion permeability of Nav1.4 are important for proper muscle responsiveness. Nav1.4's activity ensures proper muscle tone and responsiveness to neurological inputs impacting motor function and muscle reflexes directly.

Pathways

Nav1.4 is integral to pathways involved in action potential propagation and muscle contraction. It forms part of the larger excitable membrane network that includes calcium channels such as Cav1.1 and proteins like ryanodine receptors (RYRs) which participate in muscle excitation-contraction coupling. Nav1.4 has a synergistic relationship with these proteins enabling the effective transmission of electrical signals that trigger muscle contraction in response to stimuli.

Alterations in SCN4A can lead to conditions like Hyperkalemic Periodic Paralysis and Paramyotonia Congenita. Mutations affecting Nav1.4 disrupt normal muscle excitability leading to symptoms such as muscle weakness and temporary paralysis. There are associations between these disorders and other ion channels like Kir2.1 which can compound effects on membrane excitability. Understanding the role of Nav1.4 in these diseases aids in developing therapeutic strategies for muscle channelopathies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed : 12766226, PubMed : 15318338, PubMed : 16890191, PubMed : 17898326, PubMed : 18690054, PubMed : 19347921, PubMed : 25707578, PubMed : 26659129, PubMed : 26700687, PubMed : 29992740, PubMed : 30190309). Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction (PubMed : 16890191, PubMed : 19347921, PubMed : 25707578, PubMed : 26659129, PubMed : 26700687).
See full target information SCN4A
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