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AB219816

Anti-SCN4B antibody

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(2 Publications)

Rabbit Polyclonal SCN4B antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Sodium channel subunit beta-4 aa 50-150.

View Alternative Names

Sodium channel regulatory subunit beta-4, SCN4B

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCN4B antibody (AB219816)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCN4B antibody (AB219816)

Immunohistochemical analysis of paraffin embedded formalin fixed human colon issue labeling SCN4B using ab219816 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCN4B antibody (AB219816)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCN4B antibody (AB219816)

Immunohistochemical analysis of paraffin embedded formalin fixed human prostate issue labeling SCN4B using ab219816 at 1/100 dilution.

Western blot - Anti-SCN4B antibody (AB219816)
  • WB

Supplier Data

Western blot - Anti-SCN4B antibody (AB219816)

All lanes:

Western blot - Anti-SCN4B antibody (ab219816) at 1/500 dilution

Lane 1:

HepG2 cell lysate

Lane 2:

Jurkat cell lysate

Lane 3:

HepG2 cell lysate with synthesized peptide

Predicted band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human Sodium channel subunit beta-4 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q8IWT1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCN4B also known as Sodium Channel Beta-4 Subunit is a vital component in the modulation of voltage-gated sodium channels. Its molecular mass is approximately 22 kDa. SCN4B is primarily expressed in muscle tissue and the central nervous system. It functions as an auxiliary subunit to modulate the activity and kinetics of the main alpha subunit in sodium channels therefore influencing neuronal excitability and muscle contraction.
Biological function summary

SCN4B regulates the proper functioning of sodium channels which are essential for the initiation and propagation of action potentials in neurons and muscle fibers. SCN4B does not typically form a complex on its own but works as part of the sodium channel macromolecular complex. The interaction with alpha subunits modulates the gating behavior and the cellular localization of the channel impacting how electrical signals are handled in excitable cells.

Pathways

The sodium channels influenced by SCN4B are integral to the action potential pathway and the muscle contraction pathway. SCN4B's interaction with alpha subunits like SCN4A influences signal transmission efficiency and precision. The proteins SCN5A and SCN1A are also part of these sodium channel pathways playing similar roles in different tissues such as cardiac and nervous systems.

SCN4B has connections to conditions such as periodic paralysis and epilepsy. Mutations or dysregulation of SCN4B can alter neuronal excitability contributing to pathophysiological conditions. The protein links to SCN4A in conditions involving muscle function and SCN1A in neuronal-related disorders demonstrating its role in maintaining normal electrical activity and stability across tissues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed : 24297919). Modulates the activity of SCN1A/Nav1.1 (PubMed : 33712547). Modulates the activity of SCN2A/Nav1.2 (PubMed : 24297919).
See full target information Sodium channel subunit beta-4
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:110668 PubMed39246442

2024

Multiplex imaging of localized prostate tumors reveals altered spatial organization of AR-positive cells in the microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Çiğdem Ak,Zeynep Sayar,Guillaume Thibault,Erik A Burlingame,M J Kuykendall,Jennifer Eng,Alex Chitsazan,Koei Chin,Andrew C Adey,Christopher Boniface,Paul T Spellman,George V Thomas,Ryan P Kopp,Emek Demir,Young Hwan Chang,Vasilis Stavrinides,Sebnem Ece Eksi

Journal of translational medicine 19:174 PubMed33902636

2021

Identification of key methylation differentially expressed genes in posterior fossa ependymoma based on epigenomic and transcriptome analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Guanyi Wang,Yibin Jia,Yuqin Ye,Enming Kang,Huijun Chen,Jiayou Wang,Xiaosheng He
View all publications
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Product promise

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