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Goat Polyclonal SCNN1D antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SCNN1D aa 600-650.

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Key facts

Isotype

IgG

Host species

Goat

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human SCNN1D aa 600-650. The exact immunogen used to generate this antibody is proprietary information. Database link P51172
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Chimpanzee
Predicted
Gorilla
Predicted
Monkey
Predicted

Tested
Tested

Species

Human

Dilution info

2.50000-3.75000 µg/mL

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Predicted
Predicted

Species

Chimpanzee, Monkey, Gorilla

Dilution info

-

Notes

-

Target data

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

Alternative names

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Goat Polyclonal SCNN1D antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SCNN1D aa 600-650.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human SCNN1D aa 600-650. The exact immunogen used to generate this antibody is proprietary information. Database link P51172
Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

SCNN1D plays an important role in sodium reabsorption as part of the epithelial sodium channel complex which includes alpha beta and gamma subunits. Together these subunits form a channel responsible for the movement of sodium ions into the cells critical for maintaining electrolyte balance and blood pressure. Its specific contribution enhances the channel's sensitivity and responsiveness to hormonal regulation particularly by aldosterone which modulates electrolyte transport further influencing fluid accumulations in tissues.

Activity summary

The SCNN1D gene encodes the delta subunit of the epithelial sodium channel often referred to as ENaC-delta. This subunit forms a part of the multisubunit complex that regulates sodium balance at the epithelial surface. It resides on the cell membrane and plays a mechanical role in facilitating sodium ion transport across epithelial cells. SCNN1D is about 74 kDa in size and is expressed predominantly in renal epithelium and respiratory tissues contributing to sodium homeostasis and fluid balance.

Pathways

SCNN1D acts within the aldosterone-regulated sodium reabsorption pathway and the renin-angiotensin-aldosterone system (RAAS). These pathways are essential in regulating blood pressure and fluid balance. SCNN1D works closely with other proteins like the mineralocorticoid receptor which influences ENaC activity by regulating its transcription under the stimulus of aldosterone ensuring facilitating rapid sodium uptake in epithelial cells.

Associated diseases and disorders

SCNN1D involvement becomes significant in hypertension and cystic fibrosis. Mutations or dysregulation of SCNN1D or its associated pathways can lead to altered blood pressure control due to improper sodium retention. Moreover its role in sodium reabsorption associates this subunit with cystic fibrosis where the balance of ions and fluids in the lungs impacts disease severity. The protein is also linked with cystic fibrosis transmembrane conductance regulator (CFTR) which co-regulates ion transport and channel activity across epithelial surfaces.

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCNN1D antibody (ab129274), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCNN1D antibody (ab129274)

    ab129274, at 3.75 µg/ml, staining SCNN1D in Formalin-fixed, Paraffin-embedded Human Uterus tissue by Immunohistochemistry.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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