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AB169042

Anti-SCO2 antibody

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(2 Publications)

Mouse Polyclonal SCO2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Protein SCO2 homolog, mitochondrial.

View Alternative Names

Cytochrome c oxidase assembly factor SCO2, SCO2

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Protein SCO2 homolog, mitochondrial.

O43819

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Synthesis of cytochrome c oxidase 2 (SCO2) is a mitochondrial protein essential for the formation of cytochrome c oxidase complex also known as complex IV of the electron transport chain. SCO2 has a molecular weight of approximately 29 kDa. This protein is expressed mainly in tissues with high energy demands such as the heart brain and skeletal muscles. It functions within the mitochondria playing a direct role in the maturation of the copper centers of cytochrome c oxidase which is important for the enzyme's proper function.
Biological function summary

SCO2 ensures efficient oxidative phosphorylation by participating in the assembly and maintenance of complex IV a critical component of the electron transport chain. It associates with other assembly factors and proteins to deliver copper ions to their designated sites within cytochrome c oxidase. By facilitating proper assembly SCO2 supports efficient electron transfer through the respiratory chain ultimately leading to ATP production.

Pathways

SCO2 is intimately involved in mitochondrial respiratory pathways particularly the oxidative phosphorylation pathway. This pathway is fundamental for ATP production under aerobic conditions. SCO2 interacts with proteins such as COX17 and COX20 which also participate in the copper delivery and assembly of cytochrome c oxidase. This interaction ensures the transfer of electrons from NADH and FADH2 to oxygen a process that generates a proton gradient used by ATP synthase for ATP synthesis.

Defects in SCO2 relate to conditions such as Leigh syndrome and hypertrophic cardiomyopathy. Leigh syndrome a severe neurological disorder emerges from impaired energy production due to dysfunctional cytochrome c oxidase assembly in which defective SCO2 plays a significant part. SCO2 also associates with disorders involving other proteins like SCO1 and SURF1 both of which contribute to the pathology of cytochrome c oxidase deficiencies manifesting in severe metabolic and multisystemic disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2); together with SCO1, facilitates the incorporation of copper into the Cu(A) site of MT-CO2/COX2 (PubMed : 15229189, PubMed : 17189203, PubMed : 19336478, PubMed : 35750769). Could also act as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2 (PubMed : 19336478).
See full target information Protein SCO2 homolog, mitochondrial
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Kidney international reports 10:227-246 PubMed39810759

2025

Effect of Mesenchymal Stem Cell-Derived Extracellular Vesicles Induced by Advanced Glycation End Products on Energy Metabolism in Vascular Endothelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jiabin Liang,Sihang Cheng,Qide Song,Yukuan Tang,Qian Wang,Hanwei Chen,Jie Feng,Lin Yang,Shunli Li,Zhiwei Wang,Jinghui Fan,Chen Huang

Journal of virology 92: PubMed29695422

2018

Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20.

Applications

Unspecified application

Species

Unspecified reactive species

Junjie Feng,Arthur Wickenhagen,Matthew L Turnbull,Veronica V Rezelj,Felix Kreher,Natasha L Tilston-Lunel,Gillian S Slack,Benjamin Brennan,Elina Koudriakova,Andrew E Shaw,Suzannah J Rihn,Charles M Rice,Paul D Bieniasz,Richard M Elliott,Xiaohong Shi,Sam J Wilson
View all publications
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Product promise

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