AB15090

Anti-SCP1 antibody

Name: Anti-SCP1 antibody (ab15090) | Abcam
Brand: Abcam Limited
SKU: AB15090
Price: 485 USD
Availability: InStock
Rating: 4 (3 reviews)

(3 Reviews)

(139 Publications)

Anti-SCP1 antibody (ab15090) is a rabbit polyclonal antibody detecting SCP1 in IHC-P, IHC-Fr, ICC/IF. Suitable for Mouse.

- Over 110 publications
- Trusted since 2004

View Alternative Names

Scp1, Sycp1, Synaptonemal complex protein 1, SCP-1

4 Images

Immunocytochemistry/ Immunofluorescence - Anti-SCP1 antibody (AB15090)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SCP1 antibody (AB15090)

SCP1 labeled in mouse pachytene preparation (red), using ab15090. CDK2 staining, near teleomeres, is also present (green).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody (AB15090)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody (AB15090)

Paraffin embeded IHC image of Murine SCP1 in mouse ovary using ab15090 at 1 : 750 dilution and secondary at 1 : 400.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody (AB15090)

Immunohistochemical analysis of paraffin-embedded Rat testis tissue labeling SCP1 with ab322067 at 1/200 (2.44 ug/ml) dilution, followed by a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection).

Nuclear staining on rat testis.
The image on (A) ab322067 is applied with Anti-SCP1 antibody at 1/200 dilution and (B) ab15090 is applied with Anti-SCP1 antibody at 1/800 dilution.
The section was incubated with ab322067 or ab15090 for 30 mins at room temperature.
The immunostaining was performed on a Leica Biosystems BOND® RX instrument

Counterstained with Hematoxylin.

Secondary antibody only control : Secondary antibody is a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection).

Heat mediated antigen retrieval was performed with Citrate buffer (pH 6.0, Epitope Retrieval Solution 1) for 20 mins

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody (AB15090)

Immunohistochemical analysis of paraffin-embedded Mouse testis tissue labeling SCP1 with ab322067 at 1/200 (2.44 ug/ml) dilution, followed by a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection).

Nuclear staining on mouse testis.
The image on (A) ab322067 is applied with Anti-SCP1 antibody at 1/200 dilution and (B) ab15090 is applied with Anti-SCP1 antibody at 1/800 dilution.
The section was incubated with ab322067 or ab15090 for 30 mins at room temperature.
The immunostaining was performed on a Leica Biosystems BOND® RX instrument

Counterstained with Hematoxylin.

Secondary antibody only control : Secondary antibody is a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection).

Heat mediated antigen retrieval was performed with Citrate buffer (pH 6.0, Epitope Retrieval Solution 1) for 20 mins

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

ICC/IF, IHC-P, IHC-Fr

applications

Immunogen

Synthetic Peptide within Mouse Sycp1. The exact immunogen used to generate this antibody is proprietary information.

Q62209

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/750", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/750", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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Product details

What is this antibody validated in?
Anti-SCP1 antibody (ab15090) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples.

Trusted by the scientific community
Anti-SCP1 (ab15090) was first used in a scientific publication in 2004 and has been cited over 110 times in peer-reviewed journals.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: Tris citrate/phosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCP1 also known as Small Cajal body-specific phosphatase 1 is a protein that acts as a phosphatase. This protein weighs approximately 33 kDa and is expressed in various tissues particularly in the Golgi apparatus and nucleolar regions. SCP1 functions primarily by removing phosphate groups from phosphoserine or phosphothreonine residues on various substrates which regulates their activity and function.

Biological function summary

SCP1 plays a role in RNA synthesis and processing. It is closely associated with the Cajal body a nuclear organelle involved in RNA biogenesis. Within this complex SCP1 contributes to the maturation of small nuclear ribonucleoproteins (snRNPs) which are essential components of the spliceosomal machinery. This influences how genetic information gets translated into proteins impacting cellular function and responses.

Pathways

SCP1 is integral to both RNA processing and DNA repair mechanisms. Specifically SCP1 participates in the spliceosome pathway interacting with proteins like SMN and coilin which are vital for spliceosome assembly. SCP1 is also linked to the DNA damage response pathway involving other proteins such as ATM and ATR which signal and repair DNA damage to maintain genomic stability.

SCP1 has shown connections to neurological disorders and cancer. In neurodegenerative conditions such as spinal muscular atrophy SCP1 dysregulation affects the SMN protein impacting snRNP assembly. In cancer altered SCP1 activity has been linked to changes in ATM signaling which can lead to unchecked cell growth and division. Understanding SCP1 interactions in these diseases could provide insights into novel therapeutic targets.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (PubMed : 16717126). Required for normal assembly of the central element of the synaptonemal complexes (PubMed : 15937223). Required for normal centromere pairing during meiosis (PubMed : 22761579). Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (PubMed : 15937223).

See full target information Sycp1

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Publications (139)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112878 PubMed40686610

2025

UBE2J2 is essential for the progression of meiosis prophase I during spermatogenesis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaochen Yu,Jie Cen,Yaxuan Zhang,Tongtong Li,Mingyu Zhang,Fei Gao,Hongbin Liu,Yongzhi Cao

Nucleic acids research 53: PubMed40488283

2025

Deciphering meiotic chromatin organization by SYCP3.

Applications

Unspecified application

Species

Unspecified reactive species

Shimeng Guo,Yiran Zhang,Caifeng Fei,Xiaozhao Liu,Wei Xia,Mengcheng Luo,Gonghong Wei,Weibing Qin,Chengliang Xiong,Honggang Li,Ying Yin,Ximiao He,Li-Quan Zhou

Frontiers in cell and developmental biology 13:1562403 PubMed40181825

2025

Meiotic dynamics in a unique Australian marsupial provide new insights into the evolution of neo-sex chromosomes in the early stages of differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Laia Marín-Gual,Carolyn J Hogg,J King Chang,Andrew J Pask,Marilyn B Renfree,Paul D Waters,Aurora Ruiz-Herrera

Nature 639:800-807 PubMed39972125

2025

In vitro reconstitution of meiotic DNA double-strand-break formation.

Applications

Unspecified application

Species

Unspecified reactive species

Xinzhe Tang,Zetao Hu,Jian Ding,Meixia Wu,Pin Guan,Yawei Song,Yue Yin,Wei Wu,Jinbiao Ma,Ying Huang,Ming-Han Tong

Nature communications 16:791 PubMed39824811

2025

NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exit.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenlong Kang,Chen Xu,Shuai Lu,Jie Gong,Ruoyu Yan,Gan Luo,Yuanyuan Wang,Qing He,Yifei Wu,Yitong Yan,Baomei Qian,Shenglin Han,Zhiwen Bu,Jinwen Zhang,Xian Xia,Liang Chen,Zhibin Hu,Mingyan Lin,Zheng Sun,Yayun Gu,Lan Ye

Development (Cambridge, England) 152: PubMed39817676

2025

BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovary.

Applications

Unspecified application

Species

Unspecified reactive species

Fiona K M Cheung,Chun-Wei Allen Feng,Clare Crisp,Yuji Mishina,Cassy M Spiller,Josephine Bowles

Journal of cellular and molecular medicine 28:e70109 PubMed39676730

2024

FGF20 promotes spinal cord injury repair by inhibiting the formation of necrotic corpuscle P-MLKL/P-RIP1/P-RIP3 in neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Xiong Cai,Zhenwen Xie,Juan Zhao,Wenjie Lu,Zhongwei Zhu,Min Chen,Zhiyang Huang,Yibo Ying,Yining Fu,Jiake Xu,Sipin Zhu

Acta biochimica et biophysica Sinica 57:286-294 PubMed39420835

2024

G6PC3 is involved in spermatogenesis by maintaining meiotic sex chromosome inactivation.

Applications

Unspecified application

Species

Unspecified reactive species

Yuming Cao,Shengnan Wang,Liyang Li,Wenwen Li,Yan Liang,Fei Ao,Zexiao Wei,Li Wang

eLife 12: PubMed39207914

2024

TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica Y Chotiner,N Adrian Leu,Fang Yang,Isabella G Cossu,Yongjuan Guan,Huijuan Lin,P Jeremy Wang

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2309184 PubMed38868907

2024

Maternal Obesity Induces the Meiotic Defects and Epigenetic Alterations During Fetal Oocyte Development.

Applications

Unspecified application

Species

Unspecified reactive species

Shoubin Tang,Huihua Wu,Qiuzhen Chen,Tao Tang,Jiashuo Li,Huiqing An,Shuai Zhu,Longsen Han,Hongzheng Sun,Juan Ge,Xu Qian,Xi Wang,Qiang Wang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SCP1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-SCP1 antibody (AB15090)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody (AB15090)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody (AB15090)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCP1 antibody (AB15090)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Primary Antibodies

Primary Antibodies

Secondary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (139)

Product promise