JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB105355

Anti-SCRN1 antibody

Be the first to review this product! Submit a review

|

(4 Publications)

Rabbit Polyclonal SCRN1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human SCRN1 aa 200-400.

View Alternative Names

KIAA0193, SCRN1, Secernin-1

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-SCRN1 antibody (AB105355)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SCRN1 antibody (AB105355)

Immunofluorescence of SCRN1 in Human Kidney cells using ab105355 at 20 ug/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCRN1 antibody (AB105355)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCRN1 antibody (AB105355)

ab105355, at 5ug/ml, staining SCRN1 in Human kidney tissue by immunohistochemistry.

Western blot - Anti-SCRN1 antibody (AB105355)
  • WB

Supplier Data

Western blot - Anti-SCRN1 antibody (AB105355)

All lanes:

Western blot - Anti-SCRN1 antibody (ab105355) at 1 µg/mL

Lane 1:

Human kidney tissue lysate in the absence of blocking peptide

Lane 2:

Human kidney tissue lysate in the presence of blocking peptide

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human SCRN1 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

Q12765

style
left-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB70802

Anti-ZC3H13 antibody

Western blot - Anti-ZC3H13 antibody (AB70802)

  • 5
  • 2
Proteins & Peptides

AB202177

Recombinant Human SCRN1 protein

SDS-PAGE - Recombinant Human SCRN1 protein (AB202177)

  • 0
  • 0
Proteins & Peptides

AB50036

Recombinant human TGF beta 1 protein (Active)

Bioactive

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCRN1 also known as Secernin-1 is a protein involved in endosomal trafficking and lysosomal degradation. It has a molecular mass of approximately 45 kDa. SCRN1 is widely expressed in various tissues including the brain liver and lungs suggesting its involvement in numerous cellular processes. It is known to regulate the fusion of endosomes with lysosomes ensuring the proper degradation of internalized materials.
Biological function summary

SCRN1 acts as a regulatory component facilitating vesicle-mediated transport and protein degradation. This ensures cellular homeostasis and response to extracellular stimuli. Although SCRN1 is not a part of a larger complex it demonstrates interaction with endosomal components affecting cellular protein turnover rates. Recent studies highlight its role in cellular signaling contributing to the adaptation of cells to changing environmental conditions.

Pathways

SCRN1 plays an impactful role in the endocytic and lysosomal pathways. It interacts with Rab7 an important protein in these pathways which ensures efficient lysosomal function and autophagy processes. Through its action in these pathways SCRN1 influences cellular recycle of nutrients and elimination of cellular debris contributing to cellular maintenance and turnover.

SCRN1 has been linked to neurological conditions and cancer. Dysfunctional SCRN1 activity associates with neurodegenerative diseases like Alzheimer's where the protein's impact on lysosomal degradation is disrupted. Also SCRN1 connects with proteins like amyloid precursor protein (APP) adding to the understanding of its role in these diseases. In cancer SCRN1 dysregulation may affect tumor proliferation and metastasis especially through its interactions with oncogene-related pathways.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).
See full target information SCRN1
style
left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer immunology, immunotherapy : CII 74:336 PubMed41071325

2025

The single-cell atlas of colorectal cancer reveals cellular heterogeneity and key molecular features of the tumor immune microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

JunHu Li,ZhiQiang Liu,BoYu Zhang,LiuPing You,YueNan Huang

Scientific reports 13:14922 PubMed37691034

2023

Knockdown of Secernin 1 inhibit cell invasion and migration by activating the TGF-β/Smad3 pathway in oral squamous cell carcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Li Xiao,Ting Zhang,Kaiyue Zheng,Qian Xiao,Weifang Zhang,Dandan Zhang,Dengxun Wu,Chanjuan He,Yifei Zhou,Ying Liu

Bioengineered 13:10956-10972 PubMed35484984

2022

CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Na Zhao,Chen Wang,Peng Guo,Jun Hou,Hong Yang,Ting Lan,Yehan Zhou,Jiayu Li,Ujjal K Bhawal,Yang Liu

The EMBO journal 38:e101345 PubMed31441084

2019

VAP-SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function.

Applications

Unspecified application

Species

Unspecified reactive species

Feline W Lindhout,Yujie Cao,Josta T Kevenaar,Anna Bodzęta,Riccardo Stucchi,Maria M Boumpoutsari,Eugene A Katrukha,Maarten Altelaar,Harold D MacGillavry,Casper C Hoogenraad
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com