AB105358

Anti-SCUBE1 antibody

Name: Anti-SCUBE1 antibody (ab105358) | Abcam
Brand: Abcam Limited
SKU: AB105358
Price: 470 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal SCUBE1 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human Signal peptide, CUB and EGF-like domain-containing protein 1.

View Alternative Names

SCUBE1

3 Images

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Immunocytochemistry - Anti-SCUBE1 antibody (AB105358)

Immunofluorescence of SCUBE1 in Daudi cells using ab105358 at 20 ug/ml.

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Immunocytochemistry - Anti-SCUBE1 antibody (AB105358)

Immunocytochemical analysis of SCUBE1 in Daudi cells using ab105358 at 20 µg/ml.

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Western blot - Anti-SCUBE1 antibody (AB105358)

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Western blot - Anti-SCUBE1 antibody (ab105358) at 1 µg/mL

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Daudi cell lysate at 15 µg

Predicted band size: 107 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC

applications

Immunogen

Synthetic Peptide within Human Signal peptide, CUB and EGF-like domain-containing protein 1. The exact immunogen used to generate this antibody is proprietary information.

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Specificity

ab105358 is predicted to not crossreact with other SCUBE members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "20 µg/mL", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCUBE1 also known as Signal Peptide CUB Domain and EGF-Like Domain-Containing Protein 1 is a secreted glycoprotein with a mass of approximately 110 kDa. It plays roles in cell signaling due to its structural domains including the CUB and EGF-like domains. Researchers find SCUBE1 expression mainly in endothelial cells and the early stages of embryogenesis. High levels are present in developing tissues including the heart and neural tube highlighting its significance during development.

Biological function summary

SCUBE1 takes part in modulating cellular signaling and adhesion. It acts as an extracellular matrix protein and may influence interactions between cells and their surrounding matrix. It does not function in isolation and can form complexes with other SCUBE family proteins such as SCUBE2 and SCUBE3 contributing to a range of cellular processes. Evidence indicates its involvement in cardiovascular system development and bone morphogenic protein (BMP) signaling.

Pathways

SCUBE1 participates in BMP and Hedgehog signaling pathways. These pathways are important for various development and maintenance processes in the body. SCUBE1 interacts with BMP-2 and BMP-4 to modulate signal transduction impacting differentiation and patterning during development. The protein also has connections with Indian Hedgehog (IHH) pathway indicating roles in growth plate maturation and vascular formation.

Experts associate SCUBE1 with cardiovascular diseases and neurological disorders. Elevated levels of SCUBE1 are relevant to acute thrombotic events suggesting its role as a biomarker for conditions like acute myocardial infarction. Furthermore SCUBE1 links to neurological disorders through its involvement with Alzheimer's disease. This connection relates to its influence on vascular health and the potential interaction with Amyloid-beta an important protein in Alzheimer's pathology.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.

See full target information Signal peptide, CUB and EGF-like domain-containing protein 1

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

PeerJ 12:e16719 PubMed38259670

2024

SCUBE1 promotes pulmonary artery smooth muscle cell proliferation and migration in acute pulmonary embolism by modulating BMP7.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoya Qu,Dongmei Huang,Xiaomin Zhou,Wenwen Ruan

Journal of translational medicine 20:520 PubMed36348351

2022

CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jungang Zhao,Rizhao Li,Jiacheng Li,Ziyan Chen,Zixia Lin,Baofu Zhang,Liming Deng,Gang Chen,Yi Wang

JACC. Basic to translational science 5:1073-1092 PubMed33294740

2020

SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Sun,Ying Tang,Yi-Yin Tai,Adam Handen,Jingsi Zhao,Gil Speyer,Yassmin Al Aaraj,Annie Watson,Makenna E Romanelli,John Sembrat,Mauricio Rojas,Marc A Simon,Yingze Zhang,Janet Lee,Zeyu Xiong,Partha Dutta,Sathish Badu Vasamsetti,Dennis McNamara,Bryan McVerry,Charles F McTiernan,Frank C Sciurba,Seungchan Kim,Kerri Akaya Smith,Jeremy A Mazurek,Yuchi Han,Anjali Vaidya,Seyed Mehdi Nouraie,Neil J Kelly,Stephen Y Chan

Wellcome open research 2:25 PubMed28459107

2017

A genomic atlas of human adrenal and gonad development.

Applications

IHC

Species

Human

Ignacio Del Valle,Federica Buonocore,Andrew J Duncan,Lin Lin,Martino Barenco,Rahul Parnaik,Sonia Shah,Mike Hubank,Dianne Gerrelli,John C Achermann

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SCUBE1 antibody

Immunocytochemistry - Anti-SCUBE1 antibody (AB105358)

Immunocytochemistry - Anti-SCUBE1 antibody (AB105358)

Western blot - Anti-SCUBE1 antibody (AB105358)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise