Rabbit Polyclonal SCUBE2 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SCUBE2 conjugated to Keyhole Limpet Haemocyanin.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SCUBE2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NQ36
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Rat | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Associated Products
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Target data
Function
Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22677548, PubMed:22902404). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).
Alternative names
CEGP1, SCUBE2, Protein CEGP1, Scube/You
Recommended products
Rabbit Polyclonal SCUBE2 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SCUBE2 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SCUBE2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NQ36
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SCUBE2 also known as Signal Peptide CUB Domain EGF-like 2 is a protein carrying a significant role in cellular processes. It has an approximate mass of 123 kDa and identifies as a secreted glycoprotein. SCUBE2 is expressed strongly in tissues such as the heart kidney and brain. Its structure includes several epidermal growth factor-like repeats and CUB domains which help in mediating its interactions in the cellular environment.
- Biological function summary
The SCUBE2 protein functions as an important mediator in developmental signal transduction pathways. It does not form part of a well-defined complex but interacts with other proteins to modulate key developmental signals like Hedgehog and BMP pathways. SCUBE2 participates in cell-to-cell communication assisting in the regulation of embryonic development and tissue patterning. This protein's role is essential in ensuring proper growth and differentiation in those developing tissues.
- Pathways
SCUBE2 actively engages in the Hedgehog and BMP signaling pathways. These pathways involve critical mediator proteins such as Sonic Hedgehog (SHH) and Bone Morphogenetic Proteins (BMPs) respectively. SCUBE2 interacts with these molecules to influence processes like cellular proliferation and differentiation. By participating in these pathways SCUBE2 influences developmental and cellular mechanisms ensuring proper signaling during morphogenesis and tissue development.
- Associated diseases and disorders
SCUBE2 shows significant associations with various cancers and developmental disorders. For instance alterations in SCUBE2 expression levels have been linked to breast cancer where it may affect cancer cell signaling through interactions with the BMP signaling pathway proteins such as BMP-2. It also associates with developmental disorders influencing the Hedgehog signaling pathway which involves proteins such as GLI1 and affecting proper embryonic development. Understanding SCUBE2's involvement in these diseases could provide new insights into therapeutic strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCUBE2 antibody (ab117625)
ab117625, at 5 µg/ml, staining SCUBE2 in Formalin-fixed, Paraffin-embedded Human Lung tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCUBE2 antibody (ab117625)
ab117625, at 5 µg/ml, staining SCUBE2 in Formalin-fixed, Paraffin-embedded Human Prostate tissue by Immunohistochemistry.
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