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AB228891

Anti-SDCCAG8 antibody

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(1 Publication)

Rabbit Polyclonal SDCCAG8 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SDCCAG8.

View Alternative Names

CCCAP, NPHP10, HSPC085, SDCCAG8, Serologically defined colon cancer antigen 8, Antigen NY-CO-8, Centrosomal colon cancer autoantigen protein, hCCCAP

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-SDCCAG8 antibody (AB228891)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SDCCAG8 antibody (AB228891)

A549 (human lung carcinoma cell line) cells stained for SDCCAG8 (green) using ab228891 at 1/200 dilution in ICC/IF. Cells were fixed in ice-cold methanol for 5 minutes. Alpha Tubulin, a cytoskeleton marker (red).

Nuclear counterstain : Hoechst 33342 (blue).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SDCCAG8. The exact immunogen used to generate this antibody is proprietary information.

Q86SQ7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SDCCAG8 also known as Serologically Defined Colon Cancer Antigen 8 is a protein weighing approximately 92 kDa. This protein localizes primarily to centrosomes and cilia within the cell. SDCCAG8 gets expressed in many tissues with notable expression in the ciliated cells of the respiratory tract. The protein plays roles in centrosomal organization and the regulation of cilia formation.
Biological function summary

This protein has key roles in cell division and ciliogenesis due to its interaction with other proteins involved in these processes. SDCCAG8 is part of a protein complex that is important for stabilizing centrosomes and promoting proper ciliogenesis. It interacts with centriolar proteins affecting cellular structure and function. Through these interactions SDCCAG8 supports cell cycle progression and normal cellular signaling.

Pathways

SDCCAG8 participates in the centrosome-cilium interface impacting cell division and signaling pathways such as Wnt and Hedgehog. SDCCAG8 collaborates with proteins like OFD1 and CEP290 which contribute to the integrity of these pathways. These associations ensure accurate cellular signaling and distribution of cellular components during mitosis.

SDCCAG8 mutations have been linked to disorders such as Bardet-Biedl syndrome and related ciliopathies. These diseases often involve symptoms like retinal degeneration and polydactyly. The protein's association with others like BBS4 and BBS1 highlights its involvement in the pathological mechanisms of these conditions by affecting the structure and signaling capacity of cilia.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed : 27224062).
See full target information SDCCAG8
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cardiovascular medicine 9:1062695 PubMed36568562

2022

Large-conductance Ca-activated K channel β1-subunit maintains the contractile phenotype of vascular smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Meili Wang,Shuanglei Li,Hongshan Liu,Mingyuan Liu,Jin Zhang,Yang Wu,Cangsong Xiao,Haixia Huang
View all publications
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Product promise

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