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AB231797

Anti-SDF2L1 antibody

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(1 Publication)

Rabbit Polyclonal SDF2L1 antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Sdf2l1 aa 1 to C-terminus.

View Alternative Names

Stromal cell-derived factor 2-like protein 1, SDF2-like protein 1, Sdf2l1

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDF2L1 antibody (AB231797)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDF2L1 antibody (AB231797)

Formalin-fixed, paraffin-embedded mouse testis tissue stained for SDF2L1 using ab231797 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDF2L1 antibody (AB231797)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDF2L1 antibody (AB231797)

Formalin-fixed, paraffin-embedded mouse testis tissue stained for SDF2L1 using ab231797 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-SDF2L1 antibody (AB231797)
  • WB

Supplier Data

Western blot - Anti-SDF2L1 antibody (AB231797)

All lanes:

Western blot - Anti-SDF2L1 antibody (ab231797) at 1 µg/mL

All lanes:

Mouse stomach lysate

Predicted band size: 24 kDa

false

Western blot - Anti-SDF2L1 antibody (AB231797)
  • WB

Supplier Data

Western blot - Anti-SDF2L1 antibody (AB231797)

All lanes:

Western blot - Anti-SDF2L1 antibody (ab231797) at 1 µg/mL

All lanes:

Mouse testis lysate

Predicted band size: 24 kDa,37 kDa

false

Western blot - Anti-SDF2L1 antibody (AB231797)
  • WB

Supplier Data

Western blot - Anti-SDF2L1 antibody (AB231797)

All lanes:

Western blot - Anti-SDF2L1 antibody (ab231797) at 1 µg/mL

All lanes:

Mouse pancreas lysate

Predicted band size: 24 kDa

false

Western blot - Anti-SDF2L1 antibody (AB231797)
  • WB

Supplier Data

Western blot - Anti-SDF2L1 antibody (AB231797)

All lanes:

Western blot - Anti-SDF2L1 antibody (ab231797) at 2 µg/mL

All lanes:

Recombinant mouse SDF2L1 protein

Predicted band size: 24 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Mouse Sdf2l1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9ESP1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab231797 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SDF2L1 also known as stromal cell-derived factor 2-like protein 1 is a protein with a molecular mass of around 38 kDa. Mechanically it functions as a molecular chaperone involved in protein folding within the endoplasmic reticulum (ER). It is expressed in a variety of tissues including the heart liver and kidneys where it plays a role in maintaining protein homeostasis. SDF2L1 aids in the prevention of protein aggregation and assists in the proper folding and assembly of newly synthesized polypeptides in the ER.
Biological function summary

SDF2L1 assists in maintaining ER function during cellular stress conditions. While not part of a large well-defined complex it interacts with multiple proteins to support ER stress responses and the unfolded protein response (UPR). This activity helps protect cells from dysfunction associated with accumulation of misfolded proteins and ensures the degradation or refolding of faulty proteins. As a result SDF2L1 plays a role in cellular adaptation to stress especially during periods of increased protein load.

Pathways

SDF2L1 acts in several interconnected processes involving ER stress and the UPR pathway. It interacts with proteins such as BiP/GRP78 and calnexin which are key components of the UPR. These interactions help modulate the load of unfolded proteins within the ER ensuring that cell survival mechanisms are activated appropriately. SDF2L1’s role in these pathways highlights its importance in regulating cellular stress responses and maintaining cellular equilibrium.

Malfunction or dysregulation of SDF2L1 can contribute to the development of conditions like neurodegenerative diseases and liver disorders. Misfolded protein accumulation due to impaired function of SDF2L1 can lead to cellular toxicity which is a characteristic of diseases such as Alzheimer's. SDF2L1 also interacts with proteins like CHOP which is an important mediator of cell apoptosis under chronic ER stress potentially linking it to liver conditions where ER stress is a pathological feature.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Sdf2l1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 47:11729-11745 PubMed31642493

2019

Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase.

Applications

Unspecified application

Species

Unspecified reactive species

Monisha Mohan,Deepa Akula,Arun Dhillon,Arun Goyal,Roy Anindya
View all publications
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