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AB154283

Anti-SDF4 antibody

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(2 Publications)

Rabbit Polyclonal SDF4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SDF4 aa 1-250.

View Alternative Names

CAB45, PSEC0034, SDF4, 45 kDa calcium-binding protein, Cab45, Stromal cell-derived factor 4, SDF-4

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDF4 antibody (AB154283)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDF4 antibody (AB154283)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded U87 xenograft labeling SDF4 with ab154283 at 1/500.

Western blot - Anti-SDF4 antibody (AB154283)
  • WB

Unknown

Western blot - Anti-SDF4 antibody (AB154283)

All lanes:

Western blot - Anti-SDF4 antibody (ab154283) at 1/1000 dilution

All lanes:

U-87 MG whole cell lysate at 30 µg

Predicted band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SDF4 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q9BRK5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SDF4 also known as Stromal Cell Derived Factor 4 or Cab45 is a calcium-binding protein with a molecular mass of approximately 45 kDa. It is expressed in the Golgi apparatus of cells in various tissues including pancreas liver and brain. SDF4 plays a mechanical role in sorting and trafficking of proteins through the secretory pathway specifically during the transport of secretory cargo in the Golgi.
Biological function summary

This protein participates in the regulation of calcium-dependent vesicle transport. It does not function as part of a large protein complex but interacts with different proteins in the Golgi for sorting activities. SDF4's ability to bind calcium allows it to modulate interactions necessary for vesicle movement and cargo recognition affecting how proteins exit the Golgi and are distributed to other areas of the cell.

Pathways

Studies show SDF4 is involved in the cellular secretory pathway and calcium signaling pathway. Within these pathways SDF4 interacts with proteins like co-chaperone SIL1 to ensure proper protein folding and trafficking. SDF4 also contributes to vesicle budding processes that are essential for maintaining proper cellular function and homeostasis.

Dysfunction of SDF4 links to disorders such as diabetes and neurodegenerative diseases. Abnormal SDF4 expression impacts proteins like insulin in the pancreatic pathway contributing to diabetes through misfolding or improper secretion of insulin. In neurodegenerative conditions SDF4's disrupted association with proteins involved in calcium homeostasis affects synaptic function and neuron health implicating it in diseases like Alzheimer's.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.. Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.
See full target information SDF4
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Endocrinology 166: PubMed40576438

2025

Canine Adrenomedullary and Pheochromocytoma Organoids: A Novel In Vitro Model.

Applications

Unspecified application

Species

Unspecified reactive species

Marit F van den Berg,Elpetra P M Timmermans-Sprang,Fleur C Viets,Lucas van den Berg,Fatima Danawar,Monique E van Wolferen,Hans S Kooistra,Guy C M Grinwis,Wilhelmina H A de Jong,Martijn van Faassen,Sara Galac

Diabetic medicine : a journal of the British Diabetic Association 40:e15051 PubMed36692102

2023

Identification of signalling downstream of the transcription factor forkhead box protein M1 that protects against endoplasmic reticulum stress in a diabetic foot ulcer model.

Applications

Unspecified application

Species

Unspecified reactive species

Weixia Peng,Ting Zhu,Guangda Xiang,Ting Ding,Jun Zhao,Dan Xiong,Yaqin Zhong,Youqi Zhang
View all publications
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Product promise

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