AB76867

Anti-SDPR antibody

Name: Anti-SDPR antibody (ab76867) | Abcam
Brand: Abcam Limited
SKU: AB76867
Price: 535 USD
Availability: InStock
Rating: 4 (2 reviews)

(2 Reviews)

(3 Publications)

Mouse Polyclonal SDPR antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CAVIN2.

View Alternative Names

SDPR, CAVIN2, Caveolae-associated protein 2, Cavin-2, PS-p68, Phosphatidylserine-binding protein, Serum deprivation-response protein

1 Images

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Western blot - Anti-SDPR antibody (AB76867)

All lanes:

Western blot - Anti-SDPR antibody (ab76867) at 1/500 dilution

Lane 1:

SDPR transfected 293T cell line at 25 µg

Lane 2:

non transfected 293T cell line at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 47 kDa

Observed band size: 72 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CAVIN2.

O95810

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SDPR also known as serum deprivation-response protein has a molecular mass of around 43 kDa and acts mechanically by binding to phosphatidylserine within cell membranes. It plays a role in cell shape and structure due to its interaction with the cytoskeleton. This protein is expressed highly in adipocytes and several other tissues such as lung and endothelium. It localizes mainly to caveolae which are small invaginations in the plasma membrane.

Biological function summary

The serum deprivation-response protein participates in the formation and maintenance of caveolae by serving as a caveolae scaffolding component. Its interactions with other proteins support the structural integrity of cell membranes and facilitate processes like vesicular trafficking and signal transduction. SDPR contributes to caveolae-mediated signal transduction and interacts with other proteins to perform its biological functions.

Pathways

The activities of SDPR intersect with the caveolae-mediated endocytosis and actin cytoskeleton regulation. It associates with proteins such as caveolin-1 in the caveolae structure and signaling. This interaction with structural and signaling proteins enables SDPR to influence various cellular responses including the cellular reaction to stress signals and mechanical strain.

SDPR involvement connects to pulmonary arterial hypertension and multiple myeloma. Changes in its expression can affect caveolae structure and function leading to alterations in cellular mechanics and signaling pathways. In diseases like pulmonary arterial hypertension altered interactions with known proteins like caveolin-1 can exacerbate pathophysiological processes indicating the potential impact of SDPR dysregulation on vascular pathologies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed : 19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).

See full target information CAVIN2

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of Cancer 14:2001-2014 PubMed37497407

2023

CAVIN2/SDPR Functioned as a Tumor Suppressor in Lung Adenocarcinoma from Systematic Analysis of Caveolae-Related Genes and Experimental Validation.

Applications

Unspecified application

Species

Unspecified reactive species

Keyun Zhu,Baichuan Wang,Yingxi Li,Yue Yu,Zhaohui Chen,Haoran Yue,Qingxiang Meng,Dongchen Tian,Xiaofeng Liu,Weiyu Shen,Yao Tian

Nature communications 13:7234 PubMed36433988

2022

The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane.

Applications

Unspecified application

Species

Unspecified reactive species

Claudia Matthaeus,Kem A Sochacki,Andrea M Dickey,Dmytro Puchkov,Volker Haucke,Martin Lehmann,Justin W Taraska

Frontiers in oncology 11:703501 PubMed34513683

2021

Integrated Bioinformatic Analysis of the Expression and Prognosis of Caveolae-Related Genes in Human Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Tian,Xiaofeng Liu,Jing Hu,Huan Zhang,Baichuan Wang,Yingxi Li,Li Fu,Ran Su,Yue Yu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SDPR antibody

Western blot - Anti-SDPR antibody (AB76867)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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