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AB121538

Anti-SDR-2 antibody

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(1 Publication)

Rabbit Polyclonal SDR-2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FRRS1 aa 150-350.

View Alternative Names

SDFR2, SDR2, FRRS1, Ferric-chelate reductase 1, Stromal cell-derived receptor 2, SDR-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDR-2 antibody (AB121538)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDR-2 antibody (AB121538)

ab121538 at 1/100 dilution staining SDR-2 in paraffin-embedded Human epididymis tissue by Immunohistochemistry.

Western blot - Anti-SDR-2 antibody (AB121538)
  • WB

Unknown

Western blot - Anti-SDR-2 antibody (AB121538)

All lanes:

Western blot - Anti-SDR-2 antibody (ab121538) at 1/250 dilution

Lane 1:

RT4 cell lysate

Lane 2:

U-251 MG cell lysate

Lane 3:

Human Plasma lysate

Lane 4:

Human Liver tissue lysate

Lane 5:

Human Tonsil tissue lysate

Predicted band size: 66 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human FRRS1 aa 150-350. The exact immunogen used to generate this antibody is proprietary information.

Q6ZNA5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SDR-2 protein also known as Short-chain dehydrogenase/reductase 2 plays a mechanical role in enzymatic reduction and oxidation processes. It weighs approximately 26 kDa and is found in various tissues including the liver kidney and adipose tissues. SDR-2 functions by catalyzing the conversion of substrate molecules affecting the balance of steroid hormones and other metabolites in cells.
Biological function summary

SDR-2 participates in metabolic processes that involve steroids and retinoids. It is part of enzyme families responsible for the modulation of biologically active molecules impacting several key processes like lipid metabolism and cellular proliferation. Though not forming a specific complex its interactions with substrates and cofactors are important for its activity within the cell.

Pathways

SDR-2 is involved in the retinoic acid metabolic pathway and the steroid biosynthesis pathway. It correlates with other enzymatic proteins like 17β-HSD family members sharing roles in steroid hormone regulation. These pathways are essential for maintaining cellular homeostasis and influencing cellular responses to various stimuli.

SDR-2 relates to metabolic conditions such as obesity and steroid hormone-related cancers like breast cancer. Its altered expression impacts the balance of hormones contributing to dysregulation commonly observed in these conditions. The protein also connects with enzymes such as aromatase playing a part in pathological changes linked to estrogens.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.
See full target information FRRS1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:107968 PubMed37810251

2023

Schlafen-5 inhibits LINE-1 retrotransposition.

Applications

Unspecified application

Species

Unspecified reactive species

Jiwei Ding,Shujie Wang,Qipeng Liu,Yuqing Duan,Tingting Cheng,Zhongjie Ye,Zhanding Cui,Ao Zhang,Qiuyu Liu,Zixiong Zhang,Ning Zhang,Qian Liu,Ni An,Jianyuan Zhao,Dongrong Yi,Quanjie Li,Jing Wang,Yongxin Zhang,Ling Ma,Saisai Guo,Jinhui Wang,Chen Liang,Jinming Zhou,Shan Cen,Xiaoyu Li
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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