AB155512

Anti-SEC14L2/TAP antibody

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(1 Publication)

Rabbit Polyclonal SEC14L2/TAP antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SEC14L2 aa 1-250.

View Alternative Names

C22orf6, KIAA1186, KIAA1658, SEC14L2, SEC14-like protein 2, Alpha-tocopherol-associated protein, Squalene transfer protein, Supernatant protein factor, TAP, hTAP, SPF

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC14L2/TAP antibody (AB155512)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC14L2/TAP antibody (AB155512)

Immunohistochemical analysis of paraffin-embedded H1299 xenograft labeling SEC14L2/TAP with ab155512 at 1/100 dilution.

Unknown

Western blot - Anti-SEC14L2/TAP antibody (AB155512)

10% SDS PAGE

All lanes:

Western blot - Anti-SEC14L2/TAP antibody (ab155512) at 1/500 dilution

All lanes:

U87-MG whole cell lysate at 30 µg

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SEC14L2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

O76054

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEC14L2 also known as TAP is a member of the SEC14-like family of proteins. This protein has a molecular mass of about 44 kDa. It plays an important role in lipid transport and metabolism by acting as a phosphatidylinositol transfer protein. SEC14L2 is expressed in a variety of tissues with higher levels observed in the liver. It functions by transferring phospholipids between membranes which is essential for maintaining cellular lipid homeostasis.

Biological function summary

The SEC14L2 protein influences several important cellular processes such as vesicular trafficking and signal transduction. It is capable of interacting with lipid molecules to modulate their bioavailability and distribution within cells. SEC14L2 does not function alone; it forms interactions with other proteins to fulfill its role though the specific complexes it involves remain a subject of research. This protein is important for the regulation of lipid signaling pathways linking it directly to cellular function and metabolism.

Pathways

SEC14L2 engages in lipid signaling and metabolic pathways. It is integral to maintaining phosphatidylinositol signaling a critical pathway in cellular communication. SEC14L2 interacts with other proteins involved in lipid homeostasis such as PI3K which plays a role in various signaling cascades that regulate growth and metabolism. By influencing these pathways SEC14L2 affects cell proliferation and survival establishing its importance in cell cycle regulation and metabolism.

Alterations in SEC14L2 expression or function have connections with liver cancer and metabolic syndromes. Misregulation of this protein might contribute to aberrant lipid metabolism that leads to oncogenesis highlighting its involvement in cancer biology. SEC14L2 has possible interactions with other proteins like PPARs which are important in metabolic disorders. By exploring these associations researchers gain insights into the potential therapeutic targets for diseases linked to metabolic dysregulation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.

See full target information SEC14L2

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular biology of the cell 35:ar20 PubMed38134218

2023

Recruitment of PI4KIIIβ to the Golgi by ACBD3 is dependent on an upstream pathway of a SNARE complex and golgins.

Applications

Unspecified application

Species

Unspecified reactive species

Danièle Stalder,Igor Yakunin,Conceição Pereira,Jessica Eden,David C Gershlick

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SEC14L2/TAP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC14L2/TAP antibody (AB155512)

Western blot - Anti-SEC14L2/TAP antibody (AB155512)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise