Rabbit Polyclonal SEC14L2/TAP antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SEC14L2 aa 1-250.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SEC14L2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link O76054
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Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/3000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/1000 | Notes Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0). |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Target data
Function
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Alternative names
C22orf6, KIAA1186, KIAA1658, SEC14L2, SEC14-like protein 2, Alpha-tocopherol-associated protein, Squalene transfer protein, Supernatant protein factor, TAP, hTAP, SPF
Recommended products
Rabbit Polyclonal SEC14L2/TAP antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SEC14L2 aa 1-250.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SEC14L2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information. Database link O76054
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SEC14L2 also known as TAP is a member of the SEC14-like family of proteins. This protein has a molecular mass of about 44 kDa. It plays an important role in lipid transport and metabolism by acting as a phosphatidylinositol transfer protein. SEC14L2 is expressed in a variety of tissues with higher levels observed in the liver. It functions by transferring phospholipids between membranes which is essential for maintaining cellular lipid homeostasis.
- Biological function summary
The SEC14L2 protein influences several important cellular processes such as vesicular trafficking and signal transduction. It is capable of interacting with lipid molecules to modulate their bioavailability and distribution within cells. SEC14L2 does not function alone; it forms interactions with other proteins to fulfill its role though the specific complexes it involves remain a subject of research. This protein is important for the regulation of lipid signaling pathways linking it directly to cellular function and metabolism.
- Pathways
SEC14L2 engages in lipid signaling and metabolic pathways. It is integral to maintaining phosphatidylinositol signaling a critical pathway in cellular communication. SEC14L2 interacts with other proteins involved in lipid homeostasis such as PI3K which plays a role in various signaling cascades that regulate growth and metabolism. By influencing these pathways SEC14L2 affects cell proliferation and survival establishing its importance in cell cycle regulation and metabolism.
- Associated diseases and disorders
Alterations in SEC14L2 expression or function have connections with liver cancer and metabolic syndromes. Misregulation of this protein might contribute to aberrant lipid metabolism that leads to oncogenesis highlighting its involvement in cancer biology. SEC14L2 has possible interactions with other proteins like PPARs which are important in metabolic disorders. By exploring these associations researchers gain insights into the potential therapeutic targets for diseases linked to metabolic dysregulation.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-SEC14L2/TAP antibody (ab155512)
10% SDS PAGE
All lanes: Western blot - Anti-SEC14L2/TAP antibody (ab155512) at 1/500 dilution
All lanes: U87-MG whole cell lysate at 30 µg
Predicted band size: 46 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEC14L2/TAP antibody (ab155512)
Immunohistochemical analysis of paraffin-embedded H1299 xenograft labeling SEC14L2/TAP with ab155512 at 1/100 dilution.
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Product protocols
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