AB235110

Anti-Sec14l3/TAP2 antibody

Name: Anti-Sec14l3/TAP2 antibody (ab235110) | Abcam
Brand: Abcam Limited
SKU: AB235110
Price: 525 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal Sec14l3/TAP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SEC14L3 aa 200-400.

View Alternative Names

TAP2, SEC14L3, SEC14-like protein 3, Tocopherol-associated protein 2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

Paraffin-embedded human testis tissue stained for Sec14l3/TAP2 using ab235110 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

Paraffin-embedded human lung cancer tissue stained for Sec14l3/TAP2 using ab235110 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SEC14L3 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

Q9UDX4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity >95%

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Sec14l3 also known as TAP2 or Sec14-like protein 3 is a member of the sec14 lipid transfer protein family. It has a molecular mass of approximately 45 kDa. Sec14l3 is expressed in various tissues including the brain suggesting its importance in neural functions. Mechanically Sec14l3 plays a role in lipid binding and transfer assisting in the regulation of phospholipid metabolism important for cellular homeostasis.

Biological function summary

This protein interacts with phosphatidylinositol and phosphatidylcholine contributing to lipid signaling and transport. Sec14l3 is part of a larger complex involved in lipid metabolism influencing various cellular functions by controlling lipid levels within the cell. It modulates membrane trafficking impacting neuron transmission and signaling pathways that direct cellular responses and development.

Pathways

Significant functions of Sec14l3 occur within phosphoinositide signaling and the vesicular transport pathway. It relates to essential proteins in these pathways such as PI3K and small GTPases which govern cell growth survival and intracellular trafficking processes. These interactions affect how cells respond to external signals balancing growth and response to their environment.

Sec14l3 has associations with neurological disorders and cancer. Its interaction with PI3K hints at its role in pathways altered in glioblastomas while its influence on lipid signaling connects it to diseases like Alzheimer's where lipid dysregulation is a factor. Further studies highlight potential links with proteins like tau and amyloid precursor protein in these contexts suggesting pathways for disease progression and potential therapeutic targets.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

See full target information SEC14L3

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 8:658 PubMed40274982

2025

Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Chutian Wu,Linjing Long,Min Wang,Lianli Shen,Jianjun Hu,Huijun Tang,Shufen Feng,Xiongxiu Liu,Ying Shi,Shaohui Tang,Yanfang Chen

American journal of cancer research 12:5286-5299 PubMed36504904

2022

Chronic stress promotes tumor immune evasion via the suppression of MHC-I expression and the upregulation of PD-L1.

Applications

Unspecified application

Species

Unspecified reactive species

Yuzhu Chen,Yazhi Qian,Wei Huang,Yi Zhang,Mo Wu,Yinlong Cheng,Nan Yang,Yanyong Liu

JCI insight 5: PubMed32161190

2020

Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.

Applications

Unspecified application

Species

Unspecified reactive species

Emmanuel Martin,Norbert Minet,Anne-Claire Boschat,Sylvia Sanquer,Steicy Sobrino,Christelle Lenoir,Jean Pierre de Villartay,Maria Leite-de-Moraes,Capucine Picard,Claire Soudais,Tim Bourne,Sophie Hambleton,Stephen M Hughes,Robert F Wynn,Tracy A Briggs,Smita Patel,Monica G Lawrence,Alain Fischer,Peter D Arkwright,Sylvain Latour

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Sec14l3/TAP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise