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Rabbit Polyclonal Sec14l3/TAP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SEC14L3 aa 200 to C-terminus.

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Images

Western blot - Anti-Sec14l3/TAP2 antibody (AB235110), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human SEC14L3 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UDX4

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Expected
Tested
Mouse
Tested
Expected
Rat
Predicted
Predicted

Tested
Tested

Species

Mouse

Dilution info

1/500.00000 - 1/5000.00000

Notes

-

Expected
Expected

Species

Human

Dilution info

Use at an assay dependent concentration.

Notes

-

Predicted
Predicted

Species

Rat

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/20.00000 - 1/200.00000

Notes

-

Expected
Expected

Species

Mouse

Dilution info

Use at an assay dependent concentration.

Notes

-

Predicted
Predicted

Species

Rat

Dilution info

-

Notes

-

Target data

Function

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.

Alternative names

Recommended products

Rabbit Polyclonal Sec14l3/TAP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SEC14L3 aa 200 to C-terminus.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human SEC14L3 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UDX4
Purification technique

Affinity purification Protein G

Concentration
Loading...
Purification notes

Purity >95%

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Sec14l3 also known as TAP2 or Sec14-like protein 3 is a member of the sec14 lipid transfer protein family. It has a molecular mass of approximately 45 kDa. Sec14l3 is expressed in various tissues including the brain suggesting its importance in neural functions. Mechanically Sec14l3 plays a role in lipid binding and transfer assisting in the regulation of phospholipid metabolism important for cellular homeostasis.

Biological function summary

This protein interacts with phosphatidylinositol and phosphatidylcholine contributing to lipid signaling and transport. Sec14l3 is part of a larger complex involved in lipid metabolism influencing various cellular functions by controlling lipid levels within the cell. It modulates membrane trafficking impacting neuron transmission and signaling pathways that direct cellular responses and development.

Pathways

Significant functions of Sec14l3 occur within phosphoinositide signaling and the vesicular transport pathway. It relates to essential proteins in these pathways such as PI3K and small GTPases which govern cell growth survival and intracellular trafficking processes. These interactions affect how cells respond to external signals balancing growth and response to their environment.

Associated diseases and disorders

Sec14l3 has associations with neurological disorders and cancer. Its interaction with PI3K hints at its role in pathways altered in glioblastomas while its influence on lipid signaling connects it to diseases like Alzheimer's where lipid dysregulation is a factor. Further studies highlight potential links with proteins like tau and amyloid precursor protein in these contexts suggesting pathways for disease progression and potential therapeutic targets.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

3 product images

  • Western blot - Anti-Sec14l3/TAP2 antibody (ab235110), expandable thumbnail

    Western blot - Anti-Sec14l3/TAP2 antibody (ab235110)

    All lanes: Western blot - Anti-Sec14l3/TAP2 antibody (ab235110) at 1/500 dilution

    Lane 1: Mouse liver lysate

    Lane 2: Mouse lung lysate

    Secondary

    All lanes: Goat polyclonal to rabbit IgG at 1/50000 dilution

    Predicted band size: 46 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (ab235110), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (ab235110)

    Paraffin-embedded human testis tissue stained for Sec14l3/TAP2 using ab235110 at 1/100 dilution in immunohistochemical analysis.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (ab235110), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (ab235110)

    Paraffin-embedded human lung cancer tissue stained for Sec14l3/TAP2 using ab235110 at 1/100 dilution in immunohistochemical analysis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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