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AB235110

Anti-Sec14l3/TAP2 antibody

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(3 Publications)

Rabbit Polyclonal Sec14l3/TAP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SEC14L3 aa 200 to C-terminus.

View Alternative Names

TAP2, SEC14L3, SEC14-like protein 3, Tocopherol-associated protein 2

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

Paraffin-embedded human testis tissue stained for Sec14l3/TAP2 using ab235110 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec14l3/TAP2 antibody (AB235110)

Paraffin-embedded human lung cancer tissue stained for Sec14l3/TAP2 using ab235110 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-Sec14l3/TAP2 antibody (AB235110)
  • WB

Supplier Data

Western blot - Anti-Sec14l3/TAP2 antibody (AB235110)

All lanes:

Western blot - Anti-Sec14l3/TAP2 antibody (ab235110) at 1/500 dilution

Lane 1:

Mouse liver lysate

Lane 2:

Mouse lung lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SEC14L3 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9UDX4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Sec14l3 also known as TAP2 or Sec14-like protein 3 is a member of the sec14 lipid transfer protein family. It has a molecular mass of approximately 45 kDa. Sec14l3 is expressed in various tissues including the brain suggesting its importance in neural functions. Mechanically Sec14l3 plays a role in lipid binding and transfer assisting in the regulation of phospholipid metabolism important for cellular homeostasis.
Biological function summary

This protein interacts with phosphatidylinositol and phosphatidylcholine contributing to lipid signaling and transport. Sec14l3 is part of a larger complex involved in lipid metabolism influencing various cellular functions by controlling lipid levels within the cell. It modulates membrane trafficking impacting neuron transmission and signaling pathways that direct cellular responses and development.

Pathways

Significant functions of Sec14l3 occur within phosphoinositide signaling and the vesicular transport pathway. It relates to essential proteins in these pathways such as PI3K and small GTPases which govern cell growth survival and intracellular trafficking processes. These interactions affect how cells respond to external signals balancing growth and response to their environment.

Sec14l3 has associations with neurological disorders and cancer. Its interaction with PI3K hints at its role in pathways altered in glioblastomas while its influence on lipid signaling connects it to diseases like Alzheimer's where lipid dysregulation is a factor. Further studies highlight potential links with proteins like tau and amyloid precursor protein in these contexts suggesting pathways for disease progression and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
See full target information SEC14L3
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 8:658 PubMed40274982

2025

Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Chutian Wu,Linjing Long,Min Wang,Lianli Shen,Jianjun Hu,Huijun Tang,Shufen Feng,Xiongxiu Liu,Ying Shi,Shaohui Tang,Yanfang Chen

American journal of cancer research 12:5286-5299 PubMed36504904

2022

Chronic stress promotes tumor immune evasion via the suppression of MHC-I expression and the upregulation of PD-L1.

Applications

Unspecified application

Species

Unspecified reactive species

Yuzhu Chen,Yazhi Qian,Wei Huang,Yi Zhang,Mo Wu,Yinlong Cheng,Nan Yang,Yanyong Liu

JCI insight 5: PubMed32161190

2020

Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.

Applications

Unspecified application

Species

Unspecified reactive species

Emmanuel Martin,Norbert Minet,Anne-Claire Boschat,Sylvia Sanquer,Steicy Sobrino,Christelle Lenoir,Jean Pierre de Villartay,Maria Leite-de-Moraes,Capucine Picard,Claire Soudais,Tim Bourne,Sophie Hambleton,Stephen M Hughes,Robert F Wynn,Tracy A Briggs,Smita Patel,Monica G Lawrence,Alain Fischer,Peter D Arkwright,Sylvain Latour
View all publications
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