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AB122633

Anti-Sec24C antibody

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(6 Publications)

Rabbit Polyclonal Sec24C antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SEC24C aa 200-350.

View Alternative Names

KIAA0079, SEC24C, Protein transport protein Sec24C, SEC24-related protein C

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec24C antibody (AB122633)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec24C antibody (AB122633)

ab122633 at 1/200 dilution staining Sec24C in paraffin-embedded Human stomach tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-Sec24C antibody (AB122633)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Sec24C antibody (AB122633)

ab122633 at 4 μg/ml staining SEC24C in PFA/Triton X-100 fixed/permeabilized U 251 MG cells by Immunofluorescence (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SEC24C aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

P53992

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle|Store undiluted
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein Sec24C also known as SEC24 family member C functions in vesicular trafficking. It belongs to the COPII coat complex which plays a role in transporting proteins from the endoplasmic reticulum to the Golgi apparatus. Sec24C is part of a family with a molecular mass of approximately 125 kDa and it is ubiquitously expressed in various tissues suggesting an essential role in cellular transport mechanisms.
Biological function summary

Sec24C is involved in the formation of COPII-coated vesicles which are essential for the anterograde transport of proteins. It serves as a cargo adaptor within the COPII complex consisting also of proteins such as Sec23 Sec13 and Sec31. The interaction of Sec24C with these proteins ensures the proper selection and packaging of cargo during vesicle budding therefore maintaining effective intracellular transport.

Pathways

Sec24C plays a role in the secretory pathway and is involved in the ER-to-Golgi transport. It functions in collaboration with other COPII components facilitating the packaging and movement of secretory proteins. Key proteins associated with this pathways include Sar1 and Sec23 which coordinate with Sec24C to regulate vesicle formation and cargo selection efficiently.

Disruptions in Sec24C function have been linked to neurological conditions such as Alzheimer's disease and certain forms of neurodegeneration. Altered Sec24C activity affects vesicle trafficking and protein processing interacting with proteins like APP (Amyloid precursor protein) which may lead to pathology. Understanding the role of Sec24C and its interactions could offer insights into therapeutic strategies for these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed : 10214955, PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed : 17499046, PubMed : 18843296, PubMed : 20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed : 20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed : 18843296).
See full target information SEC24C
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:7782 PubMed38012130

2023

Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Shuyao Hu,Yufeng Zhang,Qianqian Yi,Cuiwei Yang,Yanfen Liu,Yun Bai

Nature communications 14:870 PubMed36797266

2023

Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2.

Applications

Unspecified application

Species

Unspecified reactive species

Karsten Nalbach,Martina Schifferer,Debjani Bhattacharya,Hung Ho-Xuan,Wei Chou Tseng,Luis A Williams,Alexandra Stolz,Stefan F Lichtenthaler,Zvulun Elazar,Christian Behrends

The Journal of biological chemistry 298:102687 PubMed36370847

2022

Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Tang,Tingxuan Wang,Yusong Guo

Nature communications 13:5879 PubMed36202818

2022

Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.

Applications

Unspecified application

Species

Unspecified reactive species

Guochao Wei,Naseer Iqbal,Valentine V Courouble,Ashwanth C Francis,Parmit K Singh,Arpa Hudait,Arun S Annamalai,Stephanie Bester,Szu-Wei Huang,Nikoloz Shkriabai,Lorenzo Briganti,Reed Haney,Vineet N KewalRamani,Gregory A Voth,Alan N Engelman,Gregory B Melikyan,Patrick R Griffin,Francisco Asturias,Mamuka Kvaratskhelia

Nature microbiology 6:435-444 PubMed33649557

2021

Sec24C is an HIV-1 host dependency factor crucial for virus replication.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie V Rebensburg,Guochao Wei,Ross C Larue,Jared Lindenberger,Ashwanth C Francis,Arun S Annamalai,James Morrison,Nikoloz Shkriabai,Szu-Wei Huang,Vineet KewalRamani,Eric M Poeschla,Gregory B Melikyan,Mamuka Kvaratskhelia

The Journal of clinical investigation 128:3319-3332 PubMed29939162

2018

The COPII cargo adapter SEC24C is essential for neuronal homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Wang,Joung Hyuck Joo,Rebecca Mount,Brett J W Teubner,Alison Krenzer,Amber L Ward,Viraj P Ichhaporia,Elizabeth J Adams,Rami Khoriaty,Samuel T Peters,Shondra M Pruett-Miller,Stanislav S Zakharenko,David Ginsburg,Mondira Kundu
View all publications
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Product promise

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