Anti-SEC61A antibody [EPR14379] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SEC61A also known as Sec61p or protein transport protein Sec61 subunit alpha isoform 1 serves as an important component of the protein translocation process. This protein weighs approximately 54 kDa and is expressed in the endoplasmic reticulum (ER) membrane of eukaryotic cells. SEC61A forms part of the SEC61 complex which operates as a channel for polypeptide chains to enter the ER from the cytosol. It plays a central role in the translocation of nascent polypeptide chains into the ER or their integration into the ER membrane.

Biological function summary

The SEC61 complex holds significance in the translocon channel with SEC61A contributing to the determination of ER insertion or membrane integration of proteins. Its function is often associated with the ribosome as the complex forms a conduit for nascent proteins during translation. The SEC61A ensures proper protein localization with the translocon complex acting as a bridge between the ribosome and the ER. It is integral to cellular processes that require precise protein folding modification and targeting within cells.

Pathways

The role of SEC61A in protein targeting is vital for maintaining various cellular functions. The unfolded protein response (UPR) and the ER-associated degradation (ERAD) pathways depend on SEC61A for the recognition and resolution of misfolded proteins. In these pathways SEC61A interacts with the proteins like BIP and other chaperones involved in monitoring protein folding status and activating the necessary stress responses if unfolded proteins accumulate. Its involvement in these pathways highlights its importance in maintaining cellular homeostasis.

Associated diseases and disorders

Mutations or dysfunctions of SEC61A contribute to various conditions such as cystic fibrosis and diabetes. Improper function of SEC61A links to defective protein translocation leading to accumulation of misfolded proteins a characteristic observed in cystic fibrosis alongside the CFTR protein. Similarly in diabetes inefficient SEC61A function might disturb insulin production or secretion since SEC61A's role in protein translocation and processing is fundamental. Moreover SEC61A dysfunction can affect proteins like IAPP involved in β-cell amyloid formation further linking it to diabetes pathogenesis.