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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal Secretogranin 3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SCG3 aa 100-250.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | WB | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/200.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827).
Secretogranin-3, Secretogranin III, SgIII, SCG3, UNQ2502/PRO5990
Rabbit Polyclonal Secretogranin 3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SCG3 aa 100-250.
Secretogranin-3, Secretogranin III, SgIII, SCG3, UNQ2502/PRO5990
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Secretogranin 3 helps regulate hormone secretion processes. It often works alongside other granin proteins within vesicles in neuroendocrine systems. Together with proteins like chromogranin A and chromogranin B it aids in sorting and packing peptide hormones and neuropeptides critical for cell communication. This coordination ensures that necessary signaling molecules are released appropriately to maintain normal physiological functions.
Secretogranin 3 also known as SCG3 is a protein involved in the secretory pathway within cells. This protein belongs to the granin family weighing approximately 51 kDa. It is most commonly expressed in neuroendocrine cells and secretory granules throughout the body. Secretogranin 3 stores and transports peptide hormones and neuropeptides before their release into the extracellular space. As a secretory granule component it plays a role in the packaging and traffic of hormones and neuropeptides.
Secretogranin 3 operates within the secretory and neuroendocrine regulation pathways. It interacts with proteins involved in vesicle formation and transport such as synaptotagmins and syntaxins. These pathways are important in processes such as neurotransmitter release and hormone secretion. The interplay between Secretogranin 3 and these proteins supports the controlled secretion of hormones which is important for cell signaling and homeostasis.
Secretogranin 3's malfunction can associate with neuroendocrine tumors and metabolic disorders. Aberrations in SCG3 levels may correlate with altered hormone secretion leading to endocrine-related conditions. Disruption in its interaction with proteins like chromogranin A can contribute to the development or progression of certain tumors. Understanding how Secretogranin 3 and these proteins interact in disease contexts can aid in designing new therapeutic approaches.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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Terms & Conditions.
Paraffin-embedded human hippocampus tissue stained for Secretogranin 3 using ab224345 at 1/200 in immunohistochemical analysis.
All lanes: Western blot - Anti-Secretogranin 3 antibody (AB224345) at 1/100 dilution
All lanes: SH-SY5Y (human neuroblastoma cell line from bone marrow) cell lysate
Developed using the ECL technique.
Predicted band size: 53 kDa
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