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AB65821

Anti-Secretogranin 3 antibody

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(1 Publication)

Rabbit Polyclonal Secretogranin 3 antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SCG3.

View Alternative Names

UNQ2502/PRO5990, SCG3, Secretogranin-3, Secretogranin III, SgIII

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Secretogranin 3 antibody (AB65821)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Secretogranin 3 antibody (AB65821)

ab65821, at 0.5µg/ml, staining Secretogranin 3 in the cytoplasm of paraffin embedded rat brain tissue sections.

Western blot - Anti-Secretogranin 3 antibody (AB65821)
  • WB

Unknown

Western blot - Anti-Secretogranin 3 antibody (AB65821)

All lanes:

Western blot - Anti-Secretogranin 3 antibody (ab65821) at 1 µg/mL

All lanes:

Hela cell tissue lysis

Predicted band size: 53 kDa

Observed band size: 53 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human SCG3. The exact immunogen used to generate this antibody is proprietary information.

Q8WXD2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Secretogranin 3 also known as SCG3 is a protein involved in the secretory pathway within cells. This protein belongs to the granin family weighing approximately 51 kDa. It is most commonly expressed in neuroendocrine cells and secretory granules throughout the body. Secretogranin 3 stores and transports peptide hormones and neuropeptides before their release into the extracellular space. As a secretory granule component it plays a role in the packaging and traffic of hormones and neuropeptides.
Biological function summary

Secretogranin 3 helps regulate hormone secretion processes. It often works alongside other granin proteins within vesicles in neuroendocrine systems. Together with proteins like chromogranin A and chromogranin B it aids in sorting and packing peptide hormones and neuropeptides critical for cell communication. This coordination ensures that necessary signaling molecules are released appropriately to maintain normal physiological functions.

Pathways

Secretogranin 3 operates within the secretory and neuroendocrine regulation pathways. It interacts with proteins involved in vesicle formation and transport such as synaptotagmins and syntaxins. These pathways are important in processes such as neurotransmitter release and hormone secretion. The interplay between Secretogranin 3 and these proteins supports the controlled secretion of hormones which is important for cell signaling and homeostasis.

Secretogranin 3's malfunction can associate with neuroendocrine tumors and metabolic disorders. Aberrations in SCG3 levels may correlate with altered hormone secretion leading to endocrine-related conditions. Disruption in its interaction with proteins like chromogranin A can contribute to the development or progression of certain tumors. Understanding how Secretogranin 3 and these proteins interact in disease contexts can aid in designing new therapeutic approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed : 19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed : 29154827).
See full target information SCG3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 22:1030 PubMed34373716

2021

Weighted gene co-expression network analysis of the association between upregulated AMD1, EN1 and VGLL1 and the progression and poor prognosis of breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lijie Yang,Xuanfei Li,Yixing Luo,Tiecheng Yang,Huaqiao Wang,Liwen Shi,Maohui Feng,Wei Xie
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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