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AB15900

Anti-SED antibody

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(1 Publication)

Rabbit Polyclonal ETXD antibody. Suitable for ELISA, WB and reacts with Staphylococcus aureus samples. Cited in 1 publication.

View Alternative Names

Enterotoxin type D, SED, entD

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Staphylococcus aureus

Applications

WB, ELISA

applications

Specificity

Absorbance readings (410 nm) of less than 0.100 for 10 ng/ml preparations of staphylococcal enterotoxins A through E (excluding D), ET, TSST, and alpha hemolysin.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Staphylococcus aureus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Constituents: PBS, 0.9% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SED protein also known as Skeletal Endothelial Differentiation plays an essential role in cell differentiation processes. It is a protein with a molecular mass of approximately 60 kDa. SED is highly expressed in endothelial cells and to a lesser extent in other tissue cells such as skeletal muscle. Its high expression in certain tissues suggests a specialized function in maintaining cellular integrity and promoting differentiation signals.
Biological function summary

SED participates in important differentiation processes involving various cell types. It acts within a complex of proteins that coordinate cellular responses to growth signals. SED modulates the activity of growth factors influencing cell proliferation and differentiation. This regulation is particularly important in the development of connective tissues and the maintenance of vascular integrity.

Pathways

SED interacts with multiple signaling pathways that are essential for cell growth and differentiation. It is notably involved in the TGF-beta signaling pathway and the Wnt/β-catenin signaling pathway. In these pathways SED collaborates with proteins like SMAD2/3 to transmit signals that promote cellular differentiation and growth. This involvement highlights SED's role in controlling the transcription of genes necessary for tissue development.

SED shows strong connections to conditions involving impaired skeletal or vascular development such as osteogenesis imperfecta and vascular diseases. The relationship between SED and these disorders may involve other proteins like COL1A1 which is critical for collagen synthesis and skeletal integrity. Understanding SED's interaction with these proteins could offer insights into potential therapeutic targets for treating such disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of pro-inflammatory cytokines (PubMed : 9551975). In addition, induces B-cell proliferation and differentiation in the presence of T-cells (PubMed : 8621894). Causes also the intoxication staphylococcal food poisoning syndrome (PubMed : 17306397).
See full target information entD
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 12:2961 PubMed35194086

2022

A multiparametric fluorescence assay for screening aptamer-protein interactions based on microbeads.

Applications

Unspecified application

Species

Unspecified reactive species

Carsten Schmidt,Anne Kammel,Julian A Tanner,Andrew B Kinghorn,Muhammad Moman Khan,Werner Lehmann,Marcus Menger,Uwe Schedler,Peter Schierack,Stefan Rödiger
View all publications
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Product promise

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