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Rabbit Polyclonal ETXD antibody. Suitable for ELISA, WB and reacts with Staphylococcus aureus samples.

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Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Constituents: 0.9% Sodium chloride, 0.0268% PBS

Form

Liquid

Clonality

Polyclonal

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ELISAWB
Staphylococcus aureus
Expected
Expected

Expected
Expected

Species

Staphylococcus aureus

Dilution info

Use at an assay dependent concentration.

Notes

-

Expected
Expected

Species

Staphylococcus aureus

Dilution info

Use at an assay dependent concentration.

Notes

-

Target data

Function

Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of pro-inflammatory cytokines (PubMed:9551975). In addition, induces B-cell proliferation and differentiation in the presence of T-cells (PubMed:8621894). Causes also the intoxication staphylococcal food poisoning syndrome (PubMed:17306397).

Alternative names

Recommended products

Rabbit Polyclonal ETXD antibody. Suitable for ELISA, WB and reacts with Staphylococcus aureus samples.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Purification technique

Affinity purification Immunogen

Specificity

Absorbance readings (410 nm) of less than 0.100 for 10 ng/ml preparations of staphylococcal enterotoxins A through E (excluding D), ET, TSST, and alpha hemolysin.

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The SED protein also known as Skeletal Endothelial Differentiation plays an essential role in cell differentiation processes. It is a protein with a molecular mass of approximately 60 kDa. SED is highly expressed in endothelial cells and to a lesser extent in other tissue cells such as skeletal muscle. Its high expression in certain tissues suggests a specialized function in maintaining cellular integrity and promoting differentiation signals.

Biological function summary

SED participates in important differentiation processes involving various cell types. It acts within a complex of proteins that coordinate cellular responses to growth signals. SED modulates the activity of growth factors influencing cell proliferation and differentiation. This regulation is particularly important in the development of connective tissues and the maintenance of vascular integrity.

Pathways

SED interacts with multiple signaling pathways that are essential for cell growth and differentiation. It is notably involved in the TGF-beta signaling pathway and the Wnt/β-catenin signaling pathway. In these pathways SED collaborates with proteins like SMAD2/3 to transmit signals that promote cellular differentiation and growth. This involvement highlights SED's role in controlling the transcription of genes necessary for tissue development.

Associated diseases and disorders

SED shows strong connections to conditions involving impaired skeletal or vascular development such as osteogenesis imperfecta and vascular diseases. The relationship between SED and these disorders may involve other proteins like COL1A1 which is critical for collagen synthesis and skeletal integrity. Understanding SED's interaction with these proteins could offer insights into potential therapeutic targets for treating such disorders.

Product promise

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