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AB154052

Anti-SEL1L3 antibody

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Rabbit Polyclonal SEL1L3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SEL1L3 aa 150-400.

View Alternative Names

KIAA0746, SEL1L3, Protein sel-1 homolog 3, Suppressor of lin-12-like protein 3, Sel-1L3

2 Images
Western blot - Anti-SEL1L3 antibody (AB154052)
  • WB

Unknown

Western blot - Anti-SEL1L3 antibody (AB154052)

All lanes:

Western blot - Anti-SEL1L3 antibody (ab154052) at 1/1000 dilution

Lane 1:

NT2D1 whole cell lysate at 30 µg

Lane 2:

PC3 whole cell lysate at 30 µg

Lane 3:

U-87 MG whole cell lysate at 30 µg

Lane 4:

SK-N-SH whole cell lysate at 30 µg

Predicted band size: 129 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEL1L3 antibody (AB154052)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEL1L3 antibody (AB154052)

Immunohistochemical analysis of paraffin-embedded Human Colon carcinoma tissue, labeling SEL1L3 with ab154052 at 1/500 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SEL1L3 aa 150-400. The exact immunogen used to generate this antibody is proprietary information.

Q68CR1

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEL1L3 also known as suppressor of lin-12-like protein 3 is a critical component in cellular processes. This protein has a molecular mass of approximately 95 kDa. It finds expression in various tissues but shows high levels in the liver and pancreas. Its structure suggests its involvement in protein quality control particularly in the endoplasmic reticulum (ER).
Biological function summary

SEL1L3 functions in the ER-associated degradation (ERAD) pathway ensuring misfolded proteins are efficiently targeted and degraded. It may form part of a complex with other ERAD components contributing to cellular homeostasis. Through its activity SEL1L3 aids in preventing the accumulation of defective proteins which could otherwise be detrimental to cell function.

Pathways

SEL1L3 actively participates in the ERAD pathway and is associated with the ubiquitin-proteasome system. It works alongside other partners like HRD1 an important E3 ubiquitin ligase to facilitate the tagging of misfolded proteins for degradation. These cooperative interactions highlight its role in maintaining protein homeostasis within the ER linked to the regulation of protein folding and degradation.

Dysfunctional SEL1L3 has correlations with metabolic diseases such as diabetes and some liver disorders. It is connected with proteins like HRD1 which also play roles in these conditions. The impairment of SEL1L3's function can lead to the accumulation of misfolded proteins contributing to cellular stress and pathology in these diseases. A deeper understanding of SEL1L3 could improve insights into therapeutic strategies for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information SEL1L3
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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