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AB139949

Anti-SELK antibody

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(7 Publications)

Rabbit Polyclonal SELK antibody. Suitable for WB and reacts with Mouse samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human SELENOK.

View Alternative Names

Selk, Selenok, Selenoprotein K, SelK

1 Images
Western blot - Anti-SELK antibody (AB139949)
  • WB

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Western blot - Anti-SELK antibody (AB139949)

Lane 1:

Western blot - Anti-SELK antibody (ab139949) at 1 µg/mL

Lane 2:

Western blot - Anti-SELK antibody (ab139949) at 2 µg/mL

All lanes:

A20 cell lysate

Predicted band size: 11 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SELENOK. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6D0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle|Store undiluted
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein SELK also known as selenoprotein K plays an important role in cellular processes. SELK is a small protein with a mass of about 11.4 kDa. It is characterized by the presence of the amino acid selenocysteine which is rare and important for its function. SELK produces in various tissues including heart skeletal muscle and liver. It locates in the endoplasmic reticulum membrane where it interacts with other proteins to contribute to molecular processes essential for cell homeostasis.
Biological function summary

SELK influences the regulation of calcium flux in cells affecting cellular signaling and immune responses. It is not a stand-alone actor but associates with other proteins to form multi-protein complexes that facilitate these cellular functions. SELK participates in processes like antioxidant defense and endoplasmic reticulum stress response which protects cells from damage. By modulating the immune response SELK plays an important role in maintaining balance in the immune system.

Pathways

This protein interacts in the oxidative stress pathways and plays a role in calcium signaling. In oxidative stress pathways SELK helps protect cells against reactive oxygen species maintaining cellular health. It works closely with proteins such as selenoprotein S and other antioxidant defense proteins. In calcium signaling SELK helps regulate calcium ion flow across cellular membranes supporting various cellular functions essential for those pathways.

SELK connects to cardiovascular diseases and autoimmune disorders. Its involvement in regulating immune responses and calcium flux associates with the pathogenesis of these conditions. In cardiovascular diseases abnormal SELK expression may contribute to heart abnormalities by interacting with calcium-modulating proteins like calnexin. In autoimmune disorders a dysregulated SELK function may affect immune balance and lead to immune system malfunction. Understanding SELK interactions gives insights into these diseases and potential therapeutic approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (PubMed : 21220695). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (PubMed : 23444136). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed : 25368151). Plays a role in protection of cells from ER stress-induced apoptosis (By similarity). Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).
See full target information Selenok
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 19:e1011314 PubMed37023217

2023

Selenoprotein K enhances STING oligomerization to facilitate antiviral response.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Lv,Li Chai,Jie Wang,Mengge Wang,Danhui Qin,Hui Song,Yue Fu,Chunyuan Zhao,Jihui Jia,Wei Zhao,Mutian Jia

Redox biology 57:102500 PubMed36252341

2022

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyue You,Fan Wu,Meilin Gao,Mengyue Chen,Shu Zeng,Yang Zhang,Wei Zhao,Danyang Li,Li Wei,Xiong Z Ruan,Yaxi Chen

Antioxidants (Basel, Switzerland) 11: PubMed35883755

2022

Selenoprotein K Is Essential for the Migration and Phagocytosis of Immature Dendritic Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Huan Xia,Yongmei Wang,Jie Dai,Xin Zhang,Jun Zhou,Zhu Zeng,Yi Jia

Redox biology 50:102255 PubMed35144051

2022

Selenoprotein K protects skeletal muscle from damage and is required for satellite cells-mediated myogenic differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Shengchen Wang,Xia Zhao,Qingqing Liu,Yue Wang,Shu Li,Shiwen Xu

Biological trace element research : PubMed33107016

2020

Selenium Regulation of the Immune Function of Dendritic Cells in Mice Through the ERK, Akt and RhoA/ROCK Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Liangliang Zhang,Huan Xia,Kaide Xia,Xianmei Liu,Xin Zhang,Jie Dai,Zhu Zeng,Yi Jia

Placenta 55:81-89 PubMed28623977

2017

Loss of selenocysteine insertion sequence binding protein 2 suppresses the proliferation, migration/invasion and hormone secretion of human trophoblast cells via the PI3K/Akt and ERK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mengdi Li,Wanpeng Cheng,Jincheng Luo,Xiaoyan Hu,Tingting Nie,Hehuan Lai,Xiaolin Zheng,Fenglan Li,Hui Li

Molecular medicine reports 15:988-994 PubMed28101579

2017

Role of tRNA selenocysteine 1 associated protein 1 in the proliferation and apoptosis of cardiomyocyte‑like H9c2 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Meng-Di Li,Wan-Peng Cheng,Min-Xia Shi,Tang-Dong Ge,Xiao-Lin Zheng,Dong-Yuan Wu,Xiao-Yan Hu,Jin-Cheng Luo,Feng-Lan Li,Hui Li
View all publications
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