Rabbit Polyclonal SELK antibody. Suitable for WB and reacts with Mouse samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human SELENOK.
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- PLoS pathogens 19:e10113142023Selenoprotein K enhances STING oligomerization to facilitate antiviral response.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLin Lv,Li Chai,Jie Wang,Mengge Wang,Danhui Qin,Hui Song,Yue Fu,Chunyuan Zhao,Jihui Jia,Wei Zhao,Mutian JiaPubMed 37023217
- Redox biology 57:1025002022Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMengyue You,Fan Wu,Meilin Gao,Mengyue Chen,Shu Zeng,Yang Zhang,Wei Zhao,Danyang Li,Li Wei,Xiong Z Ruan,Yaxi ChenPubMed 36252341
- Antioxidants (Basel, Switzerland) 11:2022Selenoprotein K Is Essential for the Migration and Phagocytosis of Immature Dendritic Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHuan Xia,Yongmei Wang,Jie Dai,Xin Zhang,Jun Zhou,Zhu Zeng,Yi JiaPubMed 35883755
- Redox biology 50:1022552022Selenoprotein K protects skeletal muscle from damage and is required for satellite cells-mediated myogenic differentiation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShengchen Wang,Xia Zhao,Qingqing Liu,Yue Wang,Shu Li,Shiwen XuPubMed 35144051
- Biological trace element research :2020Selenium Regulation of the Immune Function of Dendritic Cells in Mice Through the ERK, Akt and RhoA/ROCK Pathways.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLiangliang Zhang et. al.PubMed 33107016
- Placenta 55:81-892017Loss of selenocysteine insertion sequence binding protein 2 suppresses the proliferation, migration/invasion and hormone secretion of human trophoblast cells via the PI3K/Akt and ERK signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMengdi Li et. al.PubMed 28623977
- Molecular medicine reports 15:988-9942017Role of tRNA selenocysteine 1 associated protein 1 in the proliferation and apoptosis of cardiomyocyte‑like H9c2 cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMeng-Di Li,Wan-Peng Cheng,Min-Xia Shi,Tang-Dong Ge,Xiao-Lin Zheng,Dong-Yuan Wu,Xiao-Yan Hu,Jin-Cheng Luo,Feng-Lan Li,Hui LiPubMed 28101579
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SELENOK. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y6D0
Reactivity data
Select an application| WB | |
|---|---|
| Mouse | Tested |
| Rat | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1.00000-2.00000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
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Target data
Function
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (PubMed:21220695). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (PubMed:23444136). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (By similarity). Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).
Alternative names
Selk, Selenok, Selenoprotein K, SelK
Recommended products
Rabbit Polyclonal SELK antibody. Suitable for WB and reacts with Mouse samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human SELENOK.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SELENOK. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y6D0
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle, Store undiluted
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein SELK also known as selenoprotein K plays an important role in cellular processes. SELK is a small protein with a mass of about 11.4 kDa. It is characterized by the presence of the amino acid selenocysteine which is rare and important for its function. SELK produces in various tissues including heart skeletal muscle and liver. It locates in the endoplasmic reticulum membrane where it interacts with other proteins to contribute to molecular processes essential for cell homeostasis.
- Biological function summary
SELK influences the regulation of calcium flux in cells affecting cellular signaling and immune responses. It is not a stand-alone actor but associates with other proteins to form multi-protein complexes that facilitate these cellular functions. SELK participates in processes like antioxidant defense and endoplasmic reticulum stress response which protects cells from damage. By modulating the immune response SELK plays an important role in maintaining balance in the immune system.
- Pathways
This protein interacts in the oxidative stress pathways and plays a role in calcium signaling. In oxidative stress pathways SELK helps protect cells against reactive oxygen species maintaining cellular health. It works closely with proteins such as selenoprotein S and other antioxidant defense proteins. In calcium signaling SELK helps regulate calcium ion flow across cellular membranes supporting various cellular functions essential for those pathways.
- Associated diseases and disorders
SELK connects to cardiovascular diseases and autoimmune disorders. Its involvement in regulating immune responses and calcium flux associates with the pathogenesis of these conditions. In cardiovascular diseases abnormal SELK expression may contribute to heart abnormalities by interacting with calcium-modulating proteins like calnexin. In autoimmune disorders a dysregulated SELK function may affect immune balance and lead to immune system malfunction. Understanding SELK interactions gives insights into these diseases and potential therapeutic approaches.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-SELK antibody (ab139949)
Lane 1: Western blot - Anti-SELK antibody (ab139949) at 1 µg/mL
Lane 2: Western blot - Anti-SELK antibody (ab139949) at 2 µg/mL
All lanes: A20 cell lysate
Predicted band size: 11 kDa
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