AB172957

Anti-SELO antibody [EPR11968]

RabMAb
Recombinant
What is this?

(1 Review)

(9 Publications)

Rabbit Recombinant Monoclonal SELO antibody. Suitable for WB and reacts with Human samples. Cited in 9 publications.

View Alternative Names

SELO, SELENOO, Selenoprotein O, SelO

1 Images

Supplier Data

Western blot - Anti-SELO antibody [EPR11968] (AB172957)

All lanes:

Western blot - Anti-SELO antibody [EPR11968] (ab172957) at 1/1000 dilution

Lane 1:

Fetal kidney lysate at 10 µg

Lane 2:

293T lysate at 10 µg

Lane 3:

A549 lysate at 10 µg

Lane 4:

U87-MG lysate at 10 µg

Predicted band size: 73 kDa

false

Carrier free

Anti-SELO antibody [EPR11968] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11968

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SELO also known as selenoprotein O is a protein that plays a role in cellular redox balance. The human SELO protein has a predicted mass of approximately 98 kDa. It is expressed in several tissues including the heart and skeletal muscle suggesting its importance in energy-demanding organs. The expression pattern indicates its involvement in stress response and maintenance of cellular homeostasis.

Biological function summary

SELO functions in redox homeostasis by modulating oxidative stress within cells. It participates in mitochondrial processes as it localizes predominantly within mitochondria. SELO is also a part of a protein complex where it interacts with thioredoxin and glutathione systems. This activity influences redox signaling and defends against damage to cellular components caused by excessive reactive oxygen species (ROS).

Pathways

The SELO protein plays a critical role in cellular antioxidant pathways. It interacts with the thioredoxin pathway an important element in maintaining the redox environment of the cell. SELO may have associations with proteins like thioredoxin reductase and peroxiredoxins which also operate within these antioxidant systems. This interaction helps regulate cellular responses to oxidative stress impacting overall cell survival and function.

SELO's involvement in oxidative stress management links it to conditions where oxidative damage is prevalent. Research highlights its potential role in neurodegenerative diseases such as Alzheimer's where oxidative stress contributes to neuronal damage. SELO can also intersect with proteins like tau and amyloid-beta which are important in Alzheimer’s pathology. Understanding SELO's role in these disease processes could open avenues for therapeutic interventions targeting oxidative stress.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation) (PubMed : 30270044). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein (PubMed : 24751718).

See full target information SELENOO

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:8030 PubMed40877267

2025

Organic-inorganic covalent selenium reversing ischemic reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Zushuang Xiong,Guanning Huang,Jia-Run Huang,Ying Liu,Lizhen He,Tianfeng Chen

Biological trace element research : PubMed40555955

2025

Supranutritional Selenomethionine but not Selenite Reduces Malignant Cell Transformation.

Applications

Unspecified application

Species

Unspecified reactive species

Caroline E Meyer,Maria Schwarz,Felix B Meyer,René Thierbach,Anna P Kipp

Bioactive materials 37:393-406 PubMed38689659

2024

Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease.

Applications

Unspecified application

Species

Unspecified reactive species

Chang Liu,Weiyi Wang,Haoqiang Lai,Yikang Chen,Lvyi Li,Haiwei Li,Meixiao Zhan,Tianfeng Chen,Wenqiang Cao,Xiaoling Li

Nature chemical biology 18:751-761 PubMed35637349

2022

Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.

Applications

Unspecified application

Species

Unspecified reactive species

Zhipeng Li,Lucas Ferguson,Kirandeep K Deol,Melissa A Roberts,Leslie Magtanong,Joseph M Hendricks,Gergey Alzaem Mousa,Seda Kilinc,Kaitlin Schaefer,James A Wells,Michael C Bassik,Andrei Goga,Scott J Dixon,Nicholas T Ingolia,James A Olzmann

Cell biology international 46:1236-1248 PubMed35347798

2022

Homocysteine facilitates endoplasmic reticulum stress and apoptosis of hepatocytes by suppressing ERO1α expression via cooperation between DNMT1 and G9a.

Applications

Unspecified application

Species

Unspecified reactive species

Jiangyong Shen,Yun Jiao,Ning Ding,Lin Xie,Shengchao Ma,Hui Zhang,Anning Yang,Huiping Zhang,Yideng Jiang

International journal of molecular sciences 22: PubMed34298926

2021

Selenoproteome Expression Studied by Non-Radioactive Isotopic Selenium-Labeling in Human Cell Lines.

Applications

Unspecified application

Species

Unspecified reactive species

Jordan Sonet,Anne-Laure Bulteau,Zahia Touat-Hamici,Maurine Mosca,Katarzyna Bierla,Sandra Mounicou,Ryszard Lobinski,Laurent Chavatte

Journal of animal science and biotechnology 12:65 PubMed33993883

2021

Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression, evoking oxidative stress, and activating inflammation and apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Shuang Li,Wenjuan Sun,Kai Zhang,Jiawei Zhu,Xueting Jia,Xiaoqing Guo,Qingyu Zhao,Chaohua Tang,Jingdong Yin,Junmin Zhang

Biochimica et biophysica acta. General subjects 1862:2493-2505 PubMed29660373

2018

Selenium-regulated hierarchy of human selenoproteome in cancerous and immortalized cells lines.

Applications

Unspecified application

Species

Unspecified reactive species

Zahia Touat-Hamici,Anne-Laure Bulteau,Juliusz Bianga,Hélène Jean-Jacques,Joanna Szpunar,Ryszard Lobinski,Laurent Chavatte

Cell biology international 40:1033-40 PubMed27425444

2016

Selenoprotein O deficiencies suppress chondrogenic differentiation of ATDC5 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jidong Yan,Yao Fei,Yan Han,Shemin Lu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SELO antibody [EPR11968]

Western blot - Anti-SELO antibody [EPR11968] (AB172957)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

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