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AB122587

Anti-SELT antibody

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(1 Publication)

Rabbit Polyclonal SELT antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SELENOT aa 100 to C-terminus.

View Alternative Names

SELT, UNQ150/PRO176, SELENOT, Thioredoxin reductase-like selenoprotein T, SelT

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human duodenum tissue labelling SELT with ab122587 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebral cortex tissue labelling SELT with ab122587 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling SELT with ab122587 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SELT antibody (AB122587)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebellum tissue labelling SELT with ab122587 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SELENOT aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P62341

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle|Store undiluted
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SELT also known as selenoprotein T is a selenocysteine-containing protein with a molecular mass of approximately 23 kDa. SELT shows expression in various tissues including the brain and endocrine glands. SELT locates itself in the endoplasmic reticulum membrane and plays a mechanical role as a redox enzyme. This protein is involved in thiol-disulfide exchange reactions which are critical for maintaining cellular homeostasis.
Biological function summary

Thiol-disulfide exchange reactions facilitated by SELT support proper cellular differentiation and protein folding. SELT is not known to form part of a larger protein complex and exerts its function individually within cells. Its role in redox homeostasis influences many cellular processes including growth and apoptosis. SELT activity affects cellular redox balance which is significant for overall cell health and survival.

Pathways

SELT's activity contributes to important biological pathways such as the oxidative stress response pathway and the endoplasmic reticulum-associated degradation (ERAD) pathway. In the oxidative stress response SELT acts alongside proteins like glutathione peroxidases to neutralize reactive oxygen species. Within the ERAD pathway SELT assists in maintaining homeostasis by ensuring misfolded proteins are correctly managed therefore working closely with key proteins like ubiquitin in protein degradation processes.

SELT function impacts oxidative stress-related conditions and neuroendocrine disorders. Oxidative stress imbalance is a known factor in Alzheimer's disease where SELT's functionality can influence disease progression interacting with proteins such as amyloid precursor protein (APP). Additionally SELT has relevance in disorders associated with hormone imbalance or production linking SELT indirectly with proteins like insulin in diabetes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (PubMed : 26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).
See full target information SELENOT
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:3793 PubMed38714822

2024

An interphase actin wave promotes mitochondrial content mixing and organelle homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Stephen M Coscia,Andrew S Moore,Cameron P Thompson,Christian F Tirrito,E Michael Ostap,Erika L F Holzbaur
View all publications
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Product promise

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