Anti-SEMA5B antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEMA5B also known as Semaphorin 5B is a protein weighing approximately 100 kDa. Mechanically it functions as a guidance molecule widely involved in axonal pathfinding and neural development. Its structure includes a semaphorin domain and several thrombospondin repeats giving it a capacity to interact with multiple cellular receptors. SEMA5B is expressed in various tissues with significant levels in the brain indicating its role in the nervous system. This expression pattern suggests its important influence in developmental processes where cell movement is important.

Biological function summary

SEMA5B impacts neural circuit formation and synaptic connectivity. This protein influences neuronal migration and dendritic branching affecting overall brain organization. It is a solitary protein and is not known to form part of any protein complex. Its activity involves signaling that directly modulates cellular process important for proper axonal guidance and neuronal proliferation during neurogenesis.

Pathways

Several cellular signaling cascades involve SEMA5B. Most notably it plays a role in the semaphorin-plexin signaling pathway essential for transmitting signals that direct axonal growth and guidance. SEMA5B interacts with plexin receptors which modulate the cellular response like cytoskeletal reorganization. Another significant association is with the mTOR signaling pathway where it contributes to cell growth regulation and proliferation. Proper coordination in these pathways is vital for neuronal positioning and axonal targeting.

SEMA5B impacts nervous system-related conditions. There is a notable connection to neurodevelopmental disorders specifically autism spectrum disorders where altered expression patterns can disrupt neural connectivity. Moreover links to Alzheimer's disease have been observed where the disrupted signaling of SEMA5B might play a part in neurodegenerative processes. In both cases SEMA5B interacts with other proteins such as plexins and neuropilins influencing the progression and severity of these disorders.