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AB118458

Anti-SEMAC antibody

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(2 Publications)

Rabbit Polyclonal SEMAC antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications.

View Alternative Names

KIAA1745, SEMAC, UNQ749/PRO1480, SEMA4B, Semaphorin-4B, Semaphorin-C

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEMAC antibody (AB118458)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEMAC antibody (AB118458)

Human Small Intestine : Formalin-Fixed, Paraffin-Embedded (FFPE) using ab118458 at a concentration of 20 µg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEMAC antibody (AB118458)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEMAC antibody (AB118458)

Human Skeletal Muscle : Formalin-Fixed, Paraffin-Embedded (FFPE) using ab118458 at a concentration of 20 µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "15-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEMAC also known as Semaphorin AC is a signaling protein with a molecular mass of approximately 75 kDa. SEMAC is mainly expressed in neuronal tissues particularly within the central nervous system. It functions as a guidance cue for axon development and plays a critical role in neural circuitry. This protein interacts with plexin receptors on cell surfaces to regulate axonal pathfinding and neuronal migration during development.
Biological function summary

SEMAC regulates cell signaling that contributes to neural pattern formation and synaptic plasticity. SEMAC does not operate alone; it works as part of a large receptor-ligand complex. This complex allows SEMAC to influence diverse cellular responses including cytoskeletal reorganization and cell adhesion. Through its interaction with receptor complexes SEMAC modulates critical cellular events necessary for proper neuronal network formation.

Pathways

SEMAC significantly impacts the axon guidance and neurotrophic signaling pathways. It interacts with other semaphorins and plexin receptors to mediate axon directionality and synaptic connectivity. In addition SEMAC shows functional relationships with neuropilin receptors which further enhances its role in neurodevelopmental processes. Through these pathways SEMAC helps coordinate the intricate balance of signals required for brain development and function.

The dysregulation of SEMAC expression or function links to neurological conditions such as schizophrenia and autism spectrum disorders. Aberrant SEMAC signaling affects synaptic organization and plasticity contributing to the pathophysiology of these disorders. Furthermore SEMAC interacts with other proteins implicated in these diseases such as DISC1 in schizophrenia which suggests a complex network contributing to the disease phenotype. Understanding SEMAC's role and connections could offer insights into potential therapeutic strategies for such neurological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
See full target information SEMA4B
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 14:1028404 PubMed36817485

2023

Identification of immune related gene signature for predicting prognosis of cholangiocarcinoma patients.

Applications

Unspecified application

Species

Unspecified reactive species

Zi-Jian Zhang,Yun-Peng Huang,Zhong-Tao Liu,Yong-Xiang Wang,Hui Zhou,Ke-Xiong Hou,Ji-Wang Tang,Li Xiong,Yu Wen,Sheng-Fu Huang

Acta neuropathologica 136:709-727 PubMed30136084

2018

Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy.

Applications

Unspecified application

Species

Unspecified reactive species

Mariet Allen,Xue Wang,Daniel J Serie,Samantha L Strickland,Jeremy D Burgess,Shunsuke Koga,Curtis S Younkin,Thuy T Nguyen,Kimberly G Malphrus,Sarah J Lincoln,Melissa Alamprese,Kuixi Zhu,Rui Chang,Minerva M Carrasquillo,Naomi Kouri,Melissa E Murray,Joseph S Reddy,Cory Funk,Nathan D Price,Todd E Golde,Steven G Younkin,Yan W Asmann,Julia E Crook,Dennis W Dickson,Nilüfer Ertekin-Taner
View all publications
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Product promise

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