Anti-SEMAC antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SEMAC also known as Semaphorin AC is a signaling protein with a molecular mass of approximately 75 kDa. SEMAC is mainly expressed in neuronal tissues particularly within the central nervous system. It functions as a guidance cue for axon development and plays a critical role in neural circuitry. This protein interacts with plexin receptors on cell surfaces to regulate axonal pathfinding and neuronal migration during development.

Biological function summary

SEMAC regulates cell signaling that contributes to neural pattern formation and synaptic plasticity. SEMAC does not operate alone; it works as part of a large receptor-ligand complex. This complex allows SEMAC to influence diverse cellular responses including cytoskeletal reorganization and cell adhesion. Through its interaction with receptor complexes SEMAC modulates critical cellular events necessary for proper neuronal network formation.

Pathways

SEMAC significantly impacts the axon guidance and neurotrophic signaling pathways. It interacts with other semaphorins and plexin receptors to mediate axon directionality and synaptic connectivity. In addition SEMAC shows functional relationships with neuropilin receptors which further enhances its role in neurodevelopmental processes. Through these pathways SEMAC helps coordinate the intricate balance of signals required for brain development and function.

Associated diseases and disorders

The dysregulation of SEMAC expression or function links to neurological conditions such as schizophrenia and autism spectrum disorders. Aberrant SEMAC signaling affects synaptic organization and plasticity contributing to the pathophysiology of these disorders. Furthermore SEMAC interacts with other proteins implicated in these diseases such as DISC1 in schizophrenia which suggests a complex network contributing to the disease phenotype. Understanding SEMAC's role and connections could offer insights into potential therapeutic strategies for such neurological conditions.