AB135842

Anti-Semaphorin 3c antibody

Name: Anti-Semaphorin 3c antibody (ab135842) | Abcam
Brand: Abcam Limited
SKU: AB135842

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(4 Publications)

Rabbit Polyclonal Semaphorin 3c antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human SEMA3C aa 700-750.

View Alternative Names

SEMAE, SEMA3C, Semaphorin-3C, Semaphorin-E, Sema E

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Semaphorin 3c antibody (AB135842)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Semaphorin 3c antibody (AB135842)

Immunohistochemical analysis of Paraffin-embedded Human pancreas tissue labelling Semaphorin 3c with ab135842 at 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SEMA3C aa 700-750. The exact immunogen used to generate this antibody is proprietary information.

Q99985

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab135842 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Semaphorin 3c also known as Sema3C is a secreted protein that plays a role in signal transduction. It has a mass of approximately 89 kDa. Researchers find that Sema3C is expressed in various tissues including the brain lungs and heart. This protein is part of the semaphorin family which is known for guiding axonal growth during neural development. Sema3C functions through binding to neuropilin-1 and -2 receptors facilitating essential processes in cell signaling.

Biological function summary

Semaphorin 3c has several effects on cellular dynamics. It influences axonal guidance angiogenesis and cell migration. Sema3C forms part of complex interactions with receptors and cytoplasmic proteins affecting the structure and function of the cytoskeleton in developing neurons. Additionally it plays a distinct role in vascular remodeling by regulating endothelial cells and smooth muscle proliferation. These functionalities highlight its involvement in tissue morphogenesis and development.

Pathways

Semaphorin 3c is an important player in neural development and vascular-related pathways. It interacts significantly in the axon guidance pathway where it provides directionality to growing neurons. In this context proteins such as plexins and neuropilins are directly associated with Sema3C facilitating its function in axon direction guidance. Additionally it is a part of the VEGF signaling pathway affecting angiogenic processes through interactions with VEGF family members and their respective receptors.

Semaphorin 3c is notably implicated in cancer progression and cardiovascular abnormalities. Aberrant expression of Sema3C associates with several cancer types where it can influence tumor growth and metastasis. In cardiovascular disorders anomalies in Sema3C levels are linked to conditions such as atherosclerosis. It interacts with proteins like vascular endothelial growth factor (VEGF) contributing to pathogenesis through altered cellular proliferation and migration in affected tissues.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).

See full target information SEMA3C

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

BMC cancer 23:45 PubMed36639648

2023

A meta-validated immune infiltration-related gene model predicts prognosis and immunotherapy sensitivity in HNSCC.

Applications

Unspecified application

Species

Unspecified reactive species

Yinghe Ding,Ling Chu,Qingtai Cao,Hanyu Lei,Xinyu Li,Quan Zhuang

Frontiers in cell and developmental biology 9:801715 PubMed35237609

2022

Investigation of an FGFR-Signaling-Related Prognostic Model and Immune Landscape in Head and Neck Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Chen,Ling Chu,Xinyu Li,Hao Li,Ying Zhang,Qingtai Cao,Quan Zhuang

JOR spine 3:e1098 PubMed33015573

2020

Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Abbie Binch,Joseph Snuggs,Christine L Le Maitre

Journal of proteome research 17:618-634 PubMed29182335

2017

Proteomic Landscape of Patient-Derived CD4+ T Cells in Recent-Onset Type 1 Diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Marlen F Lepper,Uli Ohmayer,Christine von Toerne,Nicole Maison,Anette-Gabriele Ziegler,Stefanie M Hauck

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Semaphorin 3c antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Semaphorin 3c antibody (AB135842)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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