Rabbit Polyclonal Semaphorin 3c antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SEMA3C.
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- BMC cancer 23:452023A meta-validated immune infiltration-related gene model predicts prognosis and immunotherapy sensitivity in HNSCC.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYinghe Ding,Ling Chu,Qingtai Cao,Hanyu Lei,Xinyu Li,Quan ZhuangPubMed 36639648
- Frontiers in cell and developmental biology 9:8017152022Investigation of an FGFR-Signaling-Related Prognostic Model and Immune Landscape in Head and Neck Squamous Cell Carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQi Chen,Ling Chu,Xinyu Li,Hao Li,Ying Zhang,Qingtai Cao,Quan ZhuangPubMed 35237609
- JOR spine 3:e10982020Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAbbie Binch et. al.PubMed 33015573
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SEMA3C. The exact immunogen used to generate this antibody is proprietary information. Database link Q99985
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/100.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
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Target data
Function
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).
Alternative names
SEMAE, SEMA3C, Semaphorin-3C, Semaphorin-E, Sema E
Recommended products
Rabbit Polyclonal Semaphorin 3c antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SEMA3C.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SEMA3C. The exact immunogen used to generate this antibody is proprietary information. Database link Q99985
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
ab135842 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Semaphorin 3c also known as Sema3C is a secreted protein that plays a role in signal transduction. It has a mass of approximately 89 kDa. Researchers find that Sema3C is expressed in various tissues including the brain lungs and heart. This protein is part of the semaphorin family which is known for guiding axonal growth during neural development. Sema3C functions through binding to neuropilin-1 and -2 receptors facilitating essential processes in cell signaling.
- Biological function summary
Semaphorin 3c has several effects on cellular dynamics. It influences axonal guidance angiogenesis and cell migration. Sema3C forms part of complex interactions with receptors and cytoplasmic proteins affecting the structure and function of the cytoskeleton in developing neurons. Additionally it plays a distinct role in vascular remodeling by regulating endothelial cells and smooth muscle proliferation. These functionalities highlight its involvement in tissue morphogenesis and development.
- Pathways
Semaphorin 3c is an important player in neural development and vascular-related pathways. It interacts significantly in the axon guidance pathway where it provides directionality to growing neurons. In this context proteins such as plexins and neuropilins are directly associated with Sema3C facilitating its function in axon direction guidance. Additionally it is a part of the VEGF signaling pathway affecting angiogenic processes through interactions with VEGF family members and their respective receptors.
- Associated diseases and disorders
Semaphorin 3c is notably implicated in cancer progression and cardiovascular abnormalities. Aberrant expression of Sema3C associates with several cancer types where it can influence tumor growth and metastasis. In cardiovascular disorders anomalies in Sema3C levels are linked to conditions such as atherosclerosis. It interacts with proteins like vascular endothelial growth factor (VEGF) contributing to pathogenesis through altered cellular proliferation and migration in affected tissues.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Semaphorin 3c antibody (ab135842)
Immunohistochemical analysis of Paraffin-embedded Human pancreas tissue labelling Semaphorin 3c with ab135842 at 1/50 dilution.
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