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AB214309

Anti-Semaphorin 3c antibody

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Rabbit Polyclonal Semaphorin 3c antibody. Suitable for IHC-P and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human SEMA3C aa 50-150 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

SEMAE, SEMA3C, Semaphorin-3C, Semaphorin-E, Sema E

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Semaphorin 3c antibody (AB214309)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Semaphorin 3c antibody (AB214309)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse intestine tissue labeling Semaphorin 3c with ab214309 at 1/200 dilution, followed by secondary antibody detection and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SEMA3C aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q99985

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Semaphorin 3c also known as Sema3C is a secreted protein that plays a role in signal transduction. It has a mass of approximately 89 kDa. Researchers find that Sema3C is expressed in various tissues including the brain lungs and heart. This protein is part of the semaphorin family which is known for guiding axonal growth during neural development. Sema3C functions through binding to neuropilin-1 and -2 receptors facilitating essential processes in cell signaling.
Biological function summary

Semaphorin 3c has several effects on cellular dynamics. It influences axonal guidance angiogenesis and cell migration. Sema3C forms part of complex interactions with receptors and cytoplasmic proteins affecting the structure and function of the cytoskeleton in developing neurons. Additionally it plays a distinct role in vascular remodeling by regulating endothelial cells and smooth muscle proliferation. These functionalities highlight its involvement in tissue morphogenesis and development.

Pathways

Semaphorin 3c is an important player in neural development and vascular-related pathways. It interacts significantly in the axon guidance pathway where it provides directionality to growing neurons. In this context proteins such as plexins and neuropilins are directly associated with Sema3C facilitating its function in axon direction guidance. Additionally it is a part of the VEGF signaling pathway affecting angiogenic processes through interactions with VEGF family members and their respective receptors.

Semaphorin 3c is notably implicated in cancer progression and cardiovascular abnormalities. Aberrant expression of Sema3C associates with several cancer types where it can influence tumor growth and metastasis. In cardiovascular disorders anomalies in Sema3C levels are linked to conditions such as atherosclerosis. It interacts with proteins like vascular endothelial growth factor (VEGF) contributing to pathogenesis through altered cellular proliferation and migration in affected tissues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).
See full target information SEMA3C
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB135842

Anti-Semaphorin 3c antibody

primary-antibodies

semaphorin-3c-antibody-ab135842

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