AB169533

Anti-SEPT10 antibody [EPR11141(B)]

RabMAb
Recombinant
What is this?

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Recombinant Monoclonal SEPT10 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

SEPT10, SEPTIN10, Septin-10

1 Images

Unknown

Western blot - Anti-SEPT10 antibody [EPR11141(B)] (AB169533)

All lanes:

Western blot - Anti-SEPT10 antibody [EPR11141(B)] (ab169533) at 1/1000 dilution

Lane 1:

HeLa cell lysate at 10 µg

Lane 2:

PC-3 cell lysate at 10 µg

Secondary

All lanes:

HRP labeled goat anti-rabbit at 1/2000 dilution

Predicted band size: 53 kDa

false

Carrier free

Anti-SEPT10 antibody [EPR11141(B)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11141(B)

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

style

left-column

Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEPT10 also known as Septin-10 is a member of the septin family characterized by its GTP-binding capability. This protein has a molecular weight of approximately 50 kDa. SEPT10 plays a significant role in cellular processes involving cytoskeletal organization. It is commonly expressed in brain lung and spleen tissues. Septins like SEPT10 form filament structures through hetero-oligomerization allowing for compartmentalization and barrier formation within cells.

Biological function summary

SEPT10 participates in cellular division and morphogenesis. It forms part of larger septin complexes which include other septin proteins acting as a scaffold for recruiting and localizing proteins essential for various biological processes. In addition SEPT10 helps in maintaining cell integrity and shape by regulating the organization of actin and microtubules contributing to centrosome organization during cell division.

Pathways

SEPT10 integrates into pathways related to cell cycle regulation and cytoskeleton organization. In particular it associates with the Rho-signaling pathway influencing cell polarity and shape. In these pathways SEPT10 interacts with proteins like Cdc42 and RhoA contributing to the dynamic remodeling of the cytoskeleton and influencing cellular responses to external stimuli.

SEPT10 has connections to cancer and neurodegenerative conditions. Alterations in SEPT10 expression levels or mutations can disrupt normal cell division influencing tumorigenesis in certain cancers. For example changes in SEPT10 have been observed in glioma a type of brain cancer. Additionally its interaction with amyloid-beta precursor protein links it to Alzheimer's disease where impaired neurogenesis and protein aggregation are prevalent. Understanding these interactions may provide deeper insights into therapeutic targets for these diseases.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).

See full target information SEPTIN10

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature cell biology 27:438-448 PubMed39984653

2025

Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties.

Applications

Unspecified application

Species

Unspecified reactive species

Dennis K Jeppesen,Zachary C Sanchez,Noah M Kelley,James B Hayes,Jessica Ambroise,Emma N Koory,Evan Krystofiak,Nilay Taneja,Qin Zhang,Matthew M Dungan,Olivia L Perkins,Matthew J Tyska,Ela W Knapik,Kevin M Dean,Amanda C Doran,Robert J Coffey,Dylan T Burnette

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SEPT10 antibody [EPR11141(B)]

Western blot - Anti-SEPT10 antibody [EPR11141(B)] (AB169533)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise