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AB213160

Anti-SEPT14 antibody

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(1 Publication)

Rabbit Polyclonal SEPT14 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SEPTIN14 aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

SEPT14, SEPTIN14, Septin-14

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEPT14 antibody (AB213160)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEPT14 antibody (AB213160)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Rat testis tissue labeling SEPT14 with ab213160 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SEPTIN14 aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q6ZU15

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEPT14 also known as Septin-14 is a member of the septin family of GTP-binding proteins. It has a molecular mass of approximately 48 kDa. SEPT14 forms filamentous structures important for cell division and cytoskeletal organization. Expression of SEPT14 occurs primarily in the testis suggesting specialized functions in male reproductive organs. It may interact with other septins to facilitate cellular processes.
Biological function summary

SEPT14 assembles with other septins to form hetero-oligomeric complexes that are important for successful cytokinesis and compartmentalization of different cellular regions. It plays a role in the structural integrity of the cell acting as a scaffold for other proteins during cellular transport and morphogenesis processes. SEPT14 contributes to the maintenance of germ cell architecture which is critical for processes involved in spermatogenesis.

Pathways

SEPT14 participates in the pathways linked to the actin cytoskeleton organization and spermatogenesis. It interacts with actin filaments aligning with proteins like SEPT7 and SEPT9 which are integral parts of the cytoskeleton. SEPT14 takes part in genetic regulatory pathways and signaling mechanisms that ensure precise cell division contributing to reproductive tissue development and stability.

SEPT14 is linked to infertility particularly male infertility and has been associated with abnormal spermatogenesis. Changes in SEPT14 expression levels or mutations can disrupt normal septin function affecting cytoskeletal dynamics and cell division. These disruptions may involve proteins like SEPT4 which also play a role in male germ cell development. Understanding SEPT14's function and its interactions offers potential therapeutic targets to address reproductive health issues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (PubMed : 33228246).
See full target information SEPTIN14
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:5728 PubMed40593621

2025

HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Byung Jo Choi,Ju Yeon Hong,Min Hee Park,Kang Ho Park,Wan Hui Han,Hee Ji Yoon,Hye Yoon Jung,Kyung Yeol Kim,Sun Ae Lee,Eun Young Lim,Jung Woo Hur,Im-Sook Song,So Yeon Jeon,Min-Koo Choi,Christina Christoffersen,Hee-Jin Kim,Seung Hyun Kim,Edward H Schuchman,Jae-Sung Bae,Hee Kyung Jin
View all publications
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Product promise

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