Rabbit Polyclonal SEPT6 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SEPTIN6.
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- Human mutation 43:2079-20902022Biallelic loss-of-function mutations in SEPTIN4 (C17ORF47), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humans.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuanxiong Wang,Xiaoyu Zhu,Yang Gao,Mingrong Lv,Kuokuo Li,Dongdong Tang,Huan Wu,Chuan Xu,Hao Geng,Qunshan Shen,Xiaomin Zha,Zongliu Duan,Jingjing Zhang,Rong Hua,Fangbiao Tao,Ping Zhou,Zhaolian Wei,Yunxia Cao,Rui Guo,Xiaojin HePubMed 36135717
- Mediators of inflammation 2021:73930292021UBC Mediated by SEPT6 Inhibited the Progression of Prostate Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRuochen Zhang,Yaojing Yang,Haijian Huang,Tao Li,Liefu Ye,Le Lin,Yongbao WeiPubMed 34966246
- Journal of molecular cell biology 13:395-4082021The septin complex links the catenin complex to the actin cytoskeleton for establishing epithelial cell polarity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXueying Wang,Wenwen Wang,Xiwei Wang,Ming Wang,Lijuan Zhu,Fatima Garba,Chuanhai Fu,Barbara Zieger,Xu Liu,Xing Liu,Xuebiao YaoPubMed 34143183
- Cancer gene therapy 29:189-2012021LSD1-mediated stabilization of SEPT6 protein activates the TGF-β1 pathway and regulates non-small-cell lung cancer metastasis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYanni Hong,Xiaofeng Li,Jinfeng ZhuPubMed 33664458
- iScience 13:138-1532019Septin 9 has Two Polybasic Domains Critical to Septin Filament Assembly and Golgi Integrity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMohyeddine Omrane et. al.PubMed 30831549
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SEPTIN6. The exact immunogen used to generate this antibody is proprietary information. Database link Q14141
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Target data
Function
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).
Alternative names
KIAA0128, SEP2, SEPT6, SEPTIN6, Septin-6
Recommended products
Rabbit Polyclonal SEPT6 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SEPTIN6.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SEPTIN6. The exact immunogen used to generate this antibody is proprietary information. Database link Q14141
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
ab138036 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SEPT6 also known as Septin-6 is a member of the septin family of GTP-binding proteins with a molecular mass of approximately 48 kDa. It forms part of the cytoskeleton and plays a role in cellular functions like cytokinesis and cell cycle regulation. SEPT6 is expressed widely in human tissues including the brain and testis. The protein interacts with other septin family members contributing to its structural role in cells.
- Biological function summary
The septin family including SEPT6 is important for cellular processes such as exocytosis and vesicle trafficking. SEPT6 forms complexes with other proteins joining septins like SEPT2 and SEPT7 contributing to the maintenance of cellular architecture. Its interaction with cell membranes allows for the formation of diffusion barriers necessary in various cellular regions and phases.
- Pathways
The septin network with SEPT6 plays significant roles in signal transduction and the regulation of cell division. The protein is integral to the MAPK/ERK pathway which controls cellular activities like growth. It closely relates to the interactions with CDC42 a small GTPase essential for actin cytoskeleton organization. SEPT6's contribution to phagocytosis and polarization exemplifies the importance of septins in cellular dynamics.
- Associated diseases and disorders
SEPT6 often associates with conditions like cancer and neurodegenerative diseases. Its dysregulation or mutation may lead to abnormal cell growth contributing to tumorigenesis. In the brain abnormal expression of SEPT6 connects with proteins like tau in neurodegenerative diseases indicating a role for SEPT6 in pathologies involving impaired cellular structures. Proper functioning of SEPT6 therefore maintains cellular integrity and its disruption may be a biomarker or therapeutic target in certain disease contexts.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-SEPT6 antibody (ab138036)
All lanes: Western blot - Anti-SEPT6 antibody (ab138036) at 1/500 dilution
All lanes: HeLa cell lysate at 30 µg
Predicted band size: 49 kDa, 50 kDa
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