AB138036

Anti-SEPT6 antibody

Name: Anti-SEPT6 antibody (ab138036) | Abcam
Brand: Abcam Limited
SKU: AB138036

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(5 Publications)

Rabbit Polyclonal SEPT6 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SEPTIN6.

View Alternative Names

KIAA0128, SEP2, SEPT6, SEPTIN6, Septin-6

1 Images

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Western blot - Anti-SEPT6 antibody (AB138036)

All lanes:

Western blot - Anti-SEPT6 antibody (ab138036) at 1/500 dilution

All lanes:

HeLa cell lysate at 30 µg

Predicted band size: 49 kDa,50 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human SEPTIN6. The exact immunogen used to generate this antibody is proprietary information.

Q14141

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab138036 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SEPT6 also known as Septin-6 is a member of the septin family of GTP-binding proteins with a molecular mass of approximately 48 kDa. It forms part of the cytoskeleton and plays a role in cellular functions like cytokinesis and cell cycle regulation. SEPT6 is expressed widely in human tissues including the brain and testis. The protein interacts with other septin family members contributing to its structural role in cells.

Biological function summary

The septin family including SEPT6 is important for cellular processes such as exocytosis and vesicle trafficking. SEPT6 forms complexes with other proteins joining septins like SEPT2 and SEPT7 contributing to the maintenance of cellular architecture. Its interaction with cell membranes allows for the formation of diffusion barriers necessary in various cellular regions and phases.

Pathways

The septin network with SEPT6 plays significant roles in signal transduction and the regulation of cell division. The protein is integral to the MAPK/ERK pathway which controls cellular activities like growth. It closely relates to the interactions with CDC42 a small GTPase essential for actin cytoskeleton organization. SEPT6's contribution to phagocytosis and polarization exemplifies the importance of septins in cellular dynamics.

SEPT6 often associates with conditions like cancer and neurodegenerative diseases. Its dysregulation or mutation may lead to abnormal cell growth contributing to tumorigenesis. In the brain abnormal expression of SEPT6 connects with proteins like tau in neurodegenerative diseases indicating a role for SEPT6 in pathologies involving impaired cellular structures. Proper functioning of SEPT6 therefore maintains cellular integrity and its disruption may be a biomarker or therapeutic target in certain disease contexts.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed : 25588830).

See full target information SEPTIN6

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Human mutation 43:2079-2090 PubMed36135717

2022

Biallelic loss-of-function mutations in SEPTIN4 (C17ORF47), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humans.

Applications

Unspecified application

Species

Unspecified reactive species

Guanxiong Wang,Xiaoyu Zhu,Yang Gao,Mingrong Lv,Kuokuo Li,Dongdong Tang,Huan Wu,Chuan Xu,Hao Geng,Qunshan Shen,Xiaomin Zha,Zongliu Duan,Jingjing Zhang,Rong Hua,Fangbiao Tao,Ping Zhou,Zhaolian Wei,Yunxia Cao,Rui Guo,Xiaojin He

Mediators of inflammation 2021:7393029 PubMed34966246

2021

UBC Mediated by SEPT6 Inhibited the Progression of Prostate Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ruochen Zhang,Yaojing Yang,Haijian Huang,Tao Li,Liefu Ye,Le Lin,Yongbao Wei

Journal of molecular cell biology 13:395-408 PubMed34143183

2021

The septin complex links the catenin complex to the actin cytoskeleton for establishing epithelial cell polarity.

Applications

Unspecified application

Species

Unspecified reactive species

Xueying Wang,Wenwen Wang,Xiwei Wang,Ming Wang,Lijuan Zhu,Fatima Garba,Chuanhai Fu,Barbara Zieger,Xu Liu,Xing Liu,Xuebiao Yao

Cancer gene therapy 29:189-201 PubMed33664458

2021

LSD1-mediated stabilization of SEPT6 protein activates the TGF-β1 pathway and regulates non-small-cell lung cancer metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Yanni Hong,Xiaofeng Li,Jinfeng Zhu

iScience 13:138-153 PubMed30831549

2019

Septin 9 has Two Polybasic Domains Critical to Septin Filament Assembly and Golgi Integrity.

Applications

Unspecified application

Species

Unspecified reactive species

Mohyeddine Omrane,Amanda Souza Camara,Cyntia Taveneau,Nassima Benzoubir,Thibault Tubiana,Jinchao Yu,Raphaël Guérois,Didier Samuel,Bruno Goud,Christian Poüs,Stéphane Bressanelli,Richard Charles Garratt,Abdou Rachid Thiam,Ama Gassama-Diagne

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SEPT6 antibody

Western blot - Anti-SEPT6 antibody (AB138036)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Proteins & Peptides

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise