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AB236894

Anti-SERINC1 antibody

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(1 Publication)

Rabbit Polyclonal SERINC1 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SERINC1 aa 300-400.

View Alternative Names

KIAA1253, TDE1L, TDE2, UNQ396/PRO732, SERINC1, Serine incorporator 1, Tumor differentially expressed protein 1-like, Tumor differentially expressed protein 2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SERINC1 antibody (AB236894)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SERINC1 antibody (AB236894)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for SERINC1 (green) using ab236894 at 1/100 dilution in ICC/IF. Secondary antibody is Alexa Fluor® 488-congugated Goat Anti-Rabbit IgG (H+L).

Western blot - Anti-SERINC1 antibody (AB236894)
  • WB

Supplier Data

Western blot - Anti-SERINC1 antibody (AB236894)

All lanes:

Western blot - Anti-SERINC1 antibody (ab236894) at 1/500 dilution

All lanes:

Mouse lung tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human SERINC1 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

Q9NRX5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SERINC1 also known as Serine Incorporator 1 is a membrane protein involved in the incorporation of serine into lipids. It has a molecular mass of approximately 53 kDa. Scientists have identified SERINC1 as highly expressed in several tissues including the brain testis and liver. The protein localizes largely at the plasma membrane and participates actively in lipid biosynthesis.
Biological function summary

SERINC1 modulates the synthesis of phosphatidylserine and sphingolipids which are critical for cellular functions. It acts as part of a larger complex playing a role in the folding and trafficking of proteins to the membrane. SERINC1's activity influences membrane-related processes which include vesicle trafficking and cell signaling. In particular the protein impacts cellular processes through the regulation of membrane composition.

Pathways

Researchers have placed SERINC1 within the lipid metabolism and serine biosynthesis pathways. SERINC1 regulates the distribution of serine into pathways necessary for lipid and nucleotide synthesis. Other proteins related to these pathways include CDP-diacylglycerol—serine O-phosphate phosphatidyltransferase 1 which is key in the phosphatidylserine biosynthetic process. The interaction between these proteins ensures proper cellular lipid composition and function.

Studies have linked SERINC1 to neurological and metabolic conditions. Dysregulation of SERINC1 is observed in some cases of schizophrenia suggesting its involvement in neurological pathways. Furthermore disturbances in lipid metabolism such as those found in metabolic syndrome may involve altered SERINC1 function. Its relationship with proteins like phosphatidylserine decarboxylase central to the production of phosphatidylethanolamine highlights its relevance in disease contexts where lipid imbalances are pronounced.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
See full target information SERINC1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in bioengineering and biotechnology 8:456 PubMed32500067

2020

Optimisation of a Novel Bio-Substrate as a Treatment for Atrophic Age-Related Macular Degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel McCormick,Ian Pearce,Stephen Kaye,Atikah Haneef
View all publications
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Product promise

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