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Rabbit Recombinant Monoclonal Serine racemase antibody. Carrier free. Suitable for IP, WB and reacts with Mouse, Rat samples.

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Images

Western blot - Anti-Serine racemase antibody [EPR18747] - BSA and Azide free (AB250608), expandable thumbnail
  • Immunoprecipitation - Anti-Serine racemase antibody [EPR18747] - BSA and Azide free (AB250608), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2 - 7.4
Constituents: PBS

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IPWB
Mouse
Tested
Tested
Rat
Expected
Tested

Tested
Tested

Species
Mouse
Dilution info
-
Notes

-

Expected
Expected

Species
Rat
Dilution info
Use at an assay dependent concentration.
Notes

-

Tested
Tested

Species
Mouse, Rat
Dilution info
-
Notes

-

Target data

Function

Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.

Alternative names

Serine racemase, D-serine ammonia-lyase, D-serine dehydratase, L-serine ammonia-lyase, L-serine dehydratase, Srr

Recommended products

Rabbit Recombinant Monoclonal Serine racemase antibody. Carrier free. Suitable for IP, WB and reacts with Mouse, Rat samples.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Carrier free
Yes
Clone number
EPR18747
Purification technique
Affinity purification Protein A
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze

Notes

ab250608 is the carrier-free version of Anti-Serine racemase antibody [EPR18747] ab182217.

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.

This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Serine racemase also known as SRR is an enzyme involved in the conversion of L-serine to D-serine a process that helps regulate neural signaling. The enzyme has a molecular mass of approximately 37 kDa and is expressed highly in the brain specifically in regions such as the hippocampus and cortex. It utilizes pyridoxal phosphate (PLP) as a cofactor to catalyze the racemization and in certain conditions it also exhibits dehydratase activity converting serine to pyruvate and ammonia.

Biological function summary

Serine racemase plays an important role in the central nervous system. D-serine the product of its action serves as a co-agonist with glutamate at the NMDA receptor which is important for synaptic plasticity and memory formation. Serine racemase also associates with proteins like PICK1 and Golga3 affecting its localization and activity within cells. The regulation of D-serine levels impacts neurotransmission and neuron viability.

Pathways

Serine racemase is integral to the serine metabolism and NMDA receptor signaling pathways. It interacts with the enzyme glycine decarboxylase which is involved in glycine metabolism demonstrating its role in amino acid regulation. Its activity connects to the glutamatergic neurotransmission pathway influencing calcium influx and downstream signaling cascades that are essential for long-term potentiation and neuroplasticity.

Associated diseases and disorders

Alterations in serine racemase activity or expression have been linked to conditions such as schizophrenia and Alzheimer's disease. In schizophrenia disruptions in D-serine levels possibly through interactions with proteins like NMDA receptor and D-amino acid oxidase can lead to impaired NMDA receptor function. In Alzheimer's disease abnormal D-serine metabolism is associated with neurodegeneration often involving proteins like amyloid-beta which exacerbates disease pathology.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com