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AB66047

Anti-Serotonin antibody

5

(4 Reviews)

|

(68 Publications)

Anti-Serotonin antibody (ab66047) is a goat polyclonal antibody detecting Serotonin.

- Over 60 publications
- Trusted since 2008

View Alternative Names

5 hydroxytryptamine, 5HT

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

IHC-FoFr

applications

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "IHCFoFr-species-checked": "testedAndGuaranteed", "IHCFoFr-species-dilution-info": "1/400 - 1/800", "IHCFoFr-species-notes": "<p>When using Biotin/Streptavidin-HRP Technique dilution of 1/5000 - 1/10000.</p>" } } }

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AB133053

Serotonin ELISA Kit

4

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We recommend this product because it’s often used in the same experiment or related research.

We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.

Product details

If the product is lyophilized upon delivery, dilute with phosphate buffer or Tris buffer at dilutions no higher than 1/10, aliquot and freeze at -15° C or lower. Antibody can be stored for up to six months if handled as described above.

Product Specifications
Anti-Serotonin antibody (ab66047) is a goat polyclonal antibody and is validated for use in IHC-FoFr.
Anti-Serotonin antibody (ab66047) specifically detects Serotonin (UniProt ID: ; Molecular weight: kDa) and is sold in 100 µL selling sizes.

Quality and Validation
Abcam's high quality validation processes ensure Anti-Serotonin antibody (ab66047) has high sensitivity and specificity.
Anti-Serotonin antibody (ab66047) has been cited over 68 times in peer reviewed journals and is trusted by the scientific community.
Anti-Serotonin antibody (ab66047) has 4 independent reviews from customers.

Related Products
Conjugation-ready, carrier free format available for antibody clone - ab157776.

Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Serotonin also known as 5-hydroxytryptamine (5-HT) is a neurotransmitter mainly involved in modulating mood emotion and behavior. It weighs approximately 176.2 Da and appears in several body tissues including the central nervous system gastrointestinal tract and blood platelets. Neurons within the raphe nuclei of the brainstem predominantly synthesize serotonin influencing various physiological processes. Its mechanical role involves binding to and activating specific serotonin receptors classified into seven different types each mediating distinct signaling pathways.
Biological function summary

Serotonin regulates multiple bodily functions beyond mood such as appetite sleep and circadian rhythm. It forms part of a complex system interacting with various receptor subtypes which include the anti-serotonergic pathways inhibiting its action. Each receptor subtype leads to different downstream effects in cells contributing to the diversity of serotonin's biological roles. For research purposes scientists often use an ELISA kit to measure serotonin levels and this can influence the ELISA test cost based on the specificity and sensitivity required.

Pathways

Serotonin participates in both the serotonergic and dopaminergic pathways illustrating its central role in neurotransmission. The serotonergic pathway is essential for transmitting nerve impulses while its interaction with the dopaminergic system significantly affects mood and reward-related behaviors. Key proteins such as tryptophan hydroxylase for serotonin synthesis and the vesicular monoamine transporter are involved within these pathways and may alter serotonin's functional availability.

Serotonin is closely linked to depression and anxiety disorders where its imbalance can lead to mood disturbances. Antidepressant treatments often target serotonin receptors or its transporters restoring its levels within synapses. Serotonin's connection to these conditions extends through its relationship with proteins like the serotonin transporter (SERT) which recycles serotonin in the synaptic cleft. Understanding these dynamics presents potential targets for interventions and anti-serotonergic agents may offer therapeutic options for managing such disorders.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (68)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed37834052

2023

Intravenous Administration of Human Muse Cells Ameliorates Deficits in a Rat Model of Subacute Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshiharu Takahashi,Takumi Kajitani,Toshiki Endo,Atsushi Nakayashiki,Tomoo Inoue,Kuniyasu Niizuma,Teiji Tominaga

Neuroscience bulletin 39:1638-1654 PubMed37405574

2023

Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Siyuan Song,Yumin Yuan,Lingling Xu,Jun Jiang,Ying Li,Yao Yan,Qing Li,Fang Zhou,Junli Cao,Licai Zhang

Iranian journal of basic medical sciences 26:532-539 PubMed37051108

2023

The gut-brain axis: Effect of electroacupuncture pretreatment on learning, memory, and JNK signaling in D-galactose-induced AD-like rats.

Applications

Unspecified application

Species

Unspecified reactive species

Min Xiao,Xue-Song Wang,Chuan He,Zhong-Sheng Huang,Hong-Ru Chen,Li-Hong Kong

eLife 12: PubMed36810133

2023

Enteroendocrine cell lineages that differentially control feeding and gut motility.

Applications

Unspecified application

Species

Unspecified reactive species

Marito Hayashi,Judith A Kaye,Ella R Douglas,Narendra R Joshi,Fiona M Gribble,Frank Reimann,Stephen D Liberles

eLife 12: PubMed36695811

2023

Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Amy Cheung,Kotaro Konno,Yuka Imamura,Aya Matsui,Manabu Abe,Kenji Sakimura,Toshikuni Sasaoka,Takeshi Uemura,Masahiko Watanabe,Kensuke Futai

Development (Cambridge, England) 149: PubMed36458556

2022

Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life.

Applications

Unspecified application

Species

Unspecified reactive species

Carla V Argañaraz,Tamara S Adjimann,Paula P Perissinotti,Mariano Soiza-Reilly

International journal of molecular sciences 23: PubMed36555213

2022

Targeted Methylation Profiling of Single Laser-Capture Microdissected Post-Mortem Brain Cells by Adapted Limiting Dilution Bisulfite Pyrosequencing (LDBSP).

Applications

Unspecified application

Species

Unspecified reactive species

Renzo J M Riemens,Gunter Kenis,Jennifer Nolz,Sonia C Susano Chaves,Diane Duroux,Ehsan Pishva,Diego Mastroeni,Kristel Van Steen,Thomas Haaf,Daniël L A van den Hove

Histology and histopathology 38:273-286 PubMed35904321

2022

Short-term high fat feeding induces inflammatory responses of tuft cells and mucosal barrier cells in the murine stomach.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia Widmayer,Pablo Pregitzer,Heinz Breer

Frontiers in neuroscience 16:903881 PubMed35801179

2022

Foxa2 and Pet1 Direct and Indirect Synergy Drive Serotonergic Neuronal Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Begüm Aydin,Michael Sierk,Mireia Moreno-Estelles,Link Tejavibulya,Nikathan Kumar,Nuria Flames,Shaun Mahony,Esteban O Mazzoni

EBioMedicine 77:103882 PubMed35182996

2022

Multiple therapeutic effects of human neural stem cells derived from induced pluripotent stem cells in a rat model of post-traumatic syringomyelia.

Applications

Unspecified application

Species

Unspecified reactive species

Tingting Xu,Xiaofei Li,Yuxi Guo,Elias Uhlin,Lena Holmberg,Sumonto Mitra,Dania Winn,Anna Falk,Erik Sundström
View all publications

Product promise

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For full details, please see our Terms & Conditions

Associated Products

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5

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