AB75348

Anti-SERPINE2/PN-1 antibody

Name: Anti-SERPINE2/PN-1 antibody (ab75348) | Abcam
Brand: Abcam Limited
SKU: AB75348

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(4 Publications)

Rabbit Polyclonal SERPINE2/PN-1 antibody. Suitable for ELISA, IHC, WB and reacts with Human samples. Cited in 4 publications.

View Alternative Names

PI7, PN1, SERPINE2, Glia-derived nexin, GDN, Peptidase inhibitor 7, Protease nexin 1, Protease nexin I, Serpin E2, PI-7, PN-1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC, ELISA, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SERPINE2/PN-1 also known as protease nexin-1 (PN1) is a serine protease inhibitor with a molecular mass of approximately 47 kDa. This inhibitory protein predominantly expresses in various tissues including the brain lungs and liver. In the central nervous system it is abundantly present and plays important roles in glial cell function. It acts by binding and inhibiting multiple serine proteases such as thrombin plasmin and trypsin. PN-1 exerts significant mechanical control over these proteases regulating processes like coagulation and fibrinolysis.

Biological function summary

The protein PN-1 is important for maintaining tissue homeostasis and controlling extracellular matrix remodeling. PN-1 does not form part of a larger complex but interacts directly with its target proteases. It shields tissues from excessive proteolytic activity therefore preventing unwarranted degradation of proteins. The protein's inhibitory action is non-specific allowing it to modulate various biological processes from inflammatory responses to tissue recovery through its action across different proteases.

Pathways

PN-1 plays a role in the regulation of coagulation and fibrinolytic pathways. In the coagulation pathway its interaction with thrombin is significant inhibiting thrombin’s activity and therefore controlling blood clot formation. In the fibrinolytic pathway PN-1 modulates the activity of plasmin an essential protease for degrading fibrin clots. By regulating these pathways PN-1 interacts with proteins such as fibrinogen and other regulatory elements within these biological systems.

The function of PN-1 connects closely with cardiovascular diseases and neurodegenerative disorders. In cardiovascular diseases excessive or insufficient activity of PN-1 may contribute to improper blood clot formation linking this protein to conditions like thrombosis. In the context of neurodegenerative disorders altered levels of PN-1 influence the activity of neurological proteases potentially impacting diseases like Alzheimer’s. PN-1 may interact with proteins like α-2-macroglobulin in these disease processes emphasizing its role in pathophysiological conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

See full target information SERPINE2

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of biological sciences 18:6008-6019 PubMed36439874

2022

Endocytosis of Peptidase Inhibitor SerpinE2 promotes Myocardial Fibrosis through activating ERK1/2 and β-catenin Signaling Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Li,Li-Fang Lv,Mu-Ge Qi-Li,Rui Yang,Yu-Jing Wang,Shuang-Shuang Chen,Ming-Xiu Zhang,Tian-Yu Li,Tong Yu,Yu-Hong Zhou,Hai-Hai Liang,Hong-Li Shan,Xue-Lian Li

Scientific reports 6:37635 PubMed27876880

2016

Overexpression of SerpinE2/protease nexin-1 Contribute to Pathological Cardiac Fibrosis via increasing Collagen Deposition.

Applications

Species

Mouse

Xuelian Li,Dandan Zhao,Zhenfeng Guo,Tianshi Li,Muge Qili,Bozhi Xu,Ming Qian,Haihai Liang,Xiaoqiang E,Samuel Chege Gitau,Lu Wang,Longtao Huangfu,Qiuxia Wu,Chaoqian Xu,Hongli Shan

Molecular medicine reports 14:881-7 PubMed27221371

2016

SerpinE2 promotes multiple cell proliferation and drug resistance in osteosarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Minzhi Mao,Wanchun Wang

Journal of cancer research and clinical oncology 141:805-12 PubMed25359682

2014

Prognostic significance of SERPINE2 in gastric cancer and its biological function in SGC7901 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Kun Wang,Bin Wang,Ai Yan Xing,Ke Sen Xu,Guang Xin Li,Zhen Hai Yu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SERPINE2/PN-1 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purity

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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